Posted by admin on Apr 30, 2023 in |
Hypercholesterolemia occurs when a high cholesterol level in the blood may lead to atherosclerosis. Scavenger receptor class B type 1 (SR-B1) is a protein found on the surface of various cells that facilitates the reverse cholesterol transport or efflux of cholesterol from peripheral tissues back to the liver. SR-B1 receives cholesterol from high-density lipoprotein (HDL), which is then transported and metabolized in the liver cells. In this study, the compound methyl benzoate isolated from Acanthaster planci was investigated for its ability to reduce hypercholesterolemia by increasing the expression of the SR-B1 gene. Using MTS assay, methyl benzoate showed a non-cytotoxic effect on hepatocellular liver carcinoma (HepG2) cells. The luciferase assay revealed that methyl benzoate increased SR-B1 promoter activity by 1.23-fold compared to the negative control. The expression of SR-B1 gene examined by real-time polymerase chain reaction (RT-PCR) increased the expression by 1.24-fold higher than that of the positive control. In addition, HDL uptake increased by 5% in the methyl benzoate-treated cells. As for the in-vivo model, methyl benzoate was...
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Posted by admin on Apr 30, 2023 in |
Incorporating the under-consumed super food ingredients rich in nutrients or functional compounds is a growing concern in healthcare product formulation. Health-ensuring cookies blend with Nelumbonucifera (Lotus) stem powder were standardized in the laboratory and found its acceptable form with comparatively higher acceptability and good flavour profile. Safety assurance is also a part of product development to assure and instruct the consumer regarding its life span or safe consumption time on storage duration. Therefore, the study further aimed at to- Aims and Objective: 1. To assess the quality of lotus stem cookies in terms of microbiological and organoleptic aspects. 2. To assess the impact of the growth of microorganisms in cookies prepared through blend of lotus stem powder. Methodology: Keeping quality of this formulated product has been assessed by enumerating the total bacteria, yeast and mould count in between a fixed time duration (0 – 90 days) and assessing its sensory qualities. AOAC (1994) suggested techniques (microbiological count assessment) and 9 point hedonic scale to observe the flavour profile were...
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Posted by admin on Apr 30, 2023 in |
Background: Pain is warning signal of the underlying pathology and is also essential for the diagnosis. Vanilla planifolia (VP) as per literature has analgesic activity. Analgesics like NSAIDs and Opioids are used for treating pain. Adverse effects limits their long-term use. Therefore, there is always a need of more effective and safe drugs. Objective: To evaluate the analgesic activity of ethanolic extract of Vanilla planifolia seeds. Material and Methods: Wistar rats weighing 150-200gms and mice 30-40 gms of either sex were included in the study. Hot plate model and acetic acid-induced writhing test was used. Animals were divided into four groups -Vehicle control, Standard control, VP Low Dose and VP High Dose. Drug treatment was given 1hr prior to the test & response to the thermal stimuli was noted on eddy’s hot plate. Drug treatment was given 1 h before and number of writhes was measured, at different time intervals 30 min up to 240 min after the injection of 1% acetic acid in writhing test. Data analyzed with...
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Posted by admin on Apr 30, 2023 in |
In the present COVID-19 situation, it poses a danger to a person’s life because of organ infection and other health problems. It is mandatory to research work to find a better COVID-19 infection diagnosis method through scans and contact tracing through the AI method. In this, a novel AI structural model is intended to identify the infection features in the respective regions of human being availability, which makes the infection monitoring easier to identify an infected and non-infected human being from the population identified. The method used for monitoring the multiplicative nature of Coronavirus infections is through contact feature tracing and infection confirmation status and confirms the Coronavirus cases from scans and feature analysis to include real-time contact tracking from the same region and distant regions, providing an efficient method to track the infection spread. The anticipated model is used to forecast coronavirus transmission using feature forecasting data. The performance assessment is compared based on the outcomes of the suggested model and shows an enhanced COVID-19 diagnostic...
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Posted by admin on Apr 30, 2023 in |
Traditionally, Croton tiglium seed oil is reported to be very effective for hair loss. Thus, the aim is to study the effectiveness of Croton tiglium with different oils in the treatment of alopecia. The study will help develop the pharmacological profile of herbal formulation, which is being reported scientifically for the first time. The herbal formulations (formulation1, formulation2, formulation3) were formulated by mixing croton oil with olive oil and pure coconut oil. For the primary irritation test, 1 ml quantity of formulations was applied over the respective test sites of one side of the spine. The test sites were observed for erythema and edema for 48 hours after application. A physical parameter study was done for hair length, density, and quantitative histomorphometric studies. Biochemical estimation was done using different biochemical parameters; this oil was applied on shaved skin area of rats for 21 days once a day and hair length, serum total protein, and total testosterone were measured. From observation and results, it can be concluded that all the...
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