Posted by admin on Apr 1, 2010 in |
Metoprolol tartrate which is used in the present study is widely used as antianginal properties. Oral bioavailability of metoprolol tartrate is around 40%. In the present work fast dissolving tablets of metoprolol tartrate have been prepared by direct compression method. Formulations were evaluated for precompressional parameters such as angle of repose, % compressibility and Hausner’s ratio. The prepared tablets were evaluated for post compressional parameters such as hardness, friability, thickness, in-vitro dispersion time, wetting time, and water absorption ratio. The prepared tablets were characterized by DSC and FTIR studies. Stability studies were carried out as per ICH guidelines for three months. Effect of superdisintegrants [such as croscarmellose sodium, sodium starch glycolate, crospovidone, and Indion 414] on wetting time, in-vitro dispersion time and stability parameter has been studied. In-vitro dispersion time decreases with increase in concentration of indion 414 upto 9% then increases. Where as in-vitro dispersion time decreases with increase in the concentration of croscarmellose sodium and in-vitro dispersion time increases with increase in concentration of sodium starch glycolate....
Read More
Posted by admin on Apr 1, 2010 in |
Mentha piperita, a commercially important medicinal plant, yields essential oils. The oil extracted by steam distillation, gives two types of waste products viz. high boiling hydrosol and bottom pitch, which sell at a very low price. Some constituents of the waste products are useful in perfumery industry and they also exhibit medicinal activities such as anti-inflammatory. The aim of present study is to characterize the value adding constituents from the target products by saponification followed by hydro- distillation....
Read More
Posted by admin on Mar 1, 2010 in |
In view of the ethanobotanical and traditional claims of Anthocephalus cadamba plant used as hypoglycemic agent and wide use of its bark, fruits and leaf extract in anti-diabetic activity. Methanolic extract of Anthocephalus cadamba bark in alloxan induce hypoglycemia in rats. In glucose loaded normal rats, hypoglycemia was observed maximum at 120 minutes after administration of ACBE (Anthocephalus cadamba bark extract). Single dose administration of ACBE produce significant hypoglycemic effect in alloxan induced diabetic rats. The present study indicates that the methanol extract of barks posses anti-diabetic properties which suggest the presence of biologically active components. The extract might be promoting glucose uptake and metabolism or inhibiting hepatic gluconeogenesis. Result from the phytochemical analysis of Anthocephalus cadamba revealed the presence of flavonoids, which has also been isolated from the other plant and found to stimulate secretion or possess an insulin-like effect....
Read More
Posted by admin on Mar 1, 2010 in |
Jatropha curcas L. and P. pinnata Pierre is gaining importance as biodiesel crop in India. Jatropha curcas L. a member of the family Euphorbiacea and Pongamia pinnata, a member of the family Leguminoseae. A study was conducted to identify common arbuscular mycorrhizal fungi present in its rhizosphere from different regions of India viz., Jodhpur (Rajasthan), Hissar (Haryana), Jhansi and Lalitpur (Uttar Pradesh) and Hyderabad (Andhra Pradesh). The results showed that different AM fungal species were present at different locations. A total of five Acaulospora AM species were recorded in different location of India. The highest frequency of occurrence was recorded for Acaulospora scrobiculata Trappe (100%), minimum frequency of occurrence was observed in A. mellea in J. curcas. The highest frequency of occurrence was recorded for Acaulospora scrobiculata Trappe (75%), Moderates frequency of occurrence was observed in A. mellea in P. pinnata. Maximum species richness was recorded at Jodhpur, followed by Jodhpur, Hissar, Hydrabad, Jhansi, Lalitpur, and Pantnagar. Isolation of five species of Acaulospora species (A. dilatata (Morton), A. denticulata ...
Read More
Posted by admin on Mar 1, 2010 in |
Butea monosperma (Fabaceae) is distributed all over India and has been used by triable as well a local people widely. Locally it is known as “Markundi” and a cool infusion of the flowers is taken in the treatment of diabetes among the Sahariya of Northwest M.P. Butea monosperma is used in the treatment of leprosy, gout, diarrhea, anti-inflammatory, diuretic and leucorrhoea. In the present work the alcoholic and aqueous extracts of leaves of Butea monosperma were evaluated for its anthelmintic activity against adult earthworms (Phertima prosthuma). The activities of the extracts were compared with standard Albendazole. Both the extracts and standard were prepared in saline water. The alcoholic and aqueous extract of the leaves showed significant anthelmintic activity and it was found that the aqueous extract activity is higher than alcoholic...
Read More
