Posted by admin on Jan 31, 2023 in |
During the severe worldwide pandemic caused due to SARS COV-2 Corona virus, Favipiravir has been used for the treatment. It is a water insoluble anti-viral drug with poor dissolution and poor flow properties, resulting in poor oral absorption and less bioavailability. For a long time, the phrase “direct compression” was used to describe the compression of a single crystalline component into a compact without the addition of any other materials. Using excipients and solvents, the crystallo-co-agglomeration process aggregates drug crystals in the form of small spherical particles to create an intermediate product with better micromeritic and mechanical characteristics, solubility, and dissolution. Crystallo-co-agglomeration is a unique approach in which the pharmaceuticals or excipients are crystallized and agglomerated concurrently from a good solvent and/or bridging liquid by adding a non-solvent. The present study aims to formulate crystallo-co-agglomerates of Favipiravir to improve its physicochemical and mechanical properties. Results obtained during the evaluation showed that CCA technique could be successfully employed as an alternative to conventional wet...
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Posted by admin on Jan 31, 2023 in |
Potentially bioactive tetradentate novel Schiff base ligand and its mononuclear metal (II) complexes have been synthesized by the condensation method of p – nitroaniline, isatin, and 2, 2′ bipyridyl molecules in the ratio of 1:1:1. The ligand and its reported complexes exactly categorized by diverse physicochemical techniques that include elemental analysis, conductance measurements, IR, electronic spectra studies, 1H NMR spectroscopy, and EPR studies. Derived complexes are exactly non-electrolyte in nature in Dimethylformamide solution because of their lower conductance values. The IR data tells us the association of C=N nitrogen atom in coordination to the metal ion. Electronical studies and magnetic measurements suggested the octahedral geometry around metal ion under investigation. The EPR spectral data shows additional proof for the octahedral geometry. The nucleolytic cleavage of the reported compounds was checked upon pUC18 DNA by gel – electrophoresis method. In this study, anti-oxidant and anti-microbial activities have also been evidently studied. The compounds show exact growth inhibitory activity over bacteria such as S. aureus, E. coli, B. subtilis and K,...
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Posted by admin on Jan 31, 2023 in |
Purpose: A serious cause of morbidity and mortality, malaria remains a major public health concern. Failure of available treatments due to the rapid emergence of drug-resistant parasite strains emphasizes the need for a continuous search for new, safe, accessible, and affordable drug treatments. Methods: In this context, an ethnobotanical survey was conducted, different parts of seventeen medicinal plants were collected, and their methanolic extracts were prepared. These extracts were evaluated for anti-plasmodial activity against two strains of Plasmodium falciparum: chloroquine-sensitive 3D7 and resistant INDO using SYBR-Green I assay. The extracts were also assessed for cytotoxic effects against HEK293 mammalian cell lines using MTT assay. Results: Two plant extracts: Albizia lebbeck and Tecomella undulata exhibited good activity with IC50 ranging from 10-20µg/ml. Among others, eight showed moderate activity (IC50= 20.1- 50µg/ml), while eight extracts either showed poor activity or were not active upto IC50=100µg/ml against Pf3 D7. The extracts with good to moderate effects showed equipotent effects against Pf INDO and were non-toxic to mammalian cell lines with selectivity indices...
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Posted by admin on Jan 31, 2023 in |
A novel, rapid, isocratic, reversed-phase HPLC method was developed to simultaneously determine betamethasone dipropionate, miconazole nitrate and chlorocresol in a topical dosage form. The separation was performed on the C18 prontosil (250 x 4.6mm x 5µ) column. The mobile phase used for this study consists of acetonitrile and phosphate buffer of pH 2 in the ratio of 70:30 v/v, respectively. The flow rate was set as 1 ml per minute. This method used a UV detector with a wavelength of 235 nm. The retention time of chlorocresol, miconazole nitrate, and betamethasone dipropionate was 4.30 min, 5.13min, and 6.49 min, respectively. Linearity was observed for betamethasone dipropionate, miconazole nitrate, and chlorocresol in the concentration range of 1 to 3 µg/ml, 40 to 120 µg/ml and 2 to 6 µg/ml, respectively. The novel, rapid, reversed-phase HPLC method can be used in the regular analysis of any drug or combination in the pharmaceutical dosage...
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Posted by admin on Jan 31, 2023 in |
The present study estimated the antidiabetic activity of methanolic extract of plant fruits of plant Withania coagulans L. Dunal. Withania coagulans (family Solanaceae) is commonly known as “Paneer ke phool” in Hindi and “Indian cheese maker” or “Vegetable rennet” in English, distributed in drier parts of India. The primary aim of this study was to confirm antidiabetic action of Withania coagulans by using the in-vitro method of glucose uptake by yeast cells using methanolic fruit extract of the sample. It is reported that the Withanolides are responsible for its anti-hyperglycemic activity, which has been standardized by the TLC method using 50% Sulphuric acid and dragendroff’s reagents as a spraying agent in this study. The current research found that Withania coagulans methanolic fruit extract improved glucose absorption in yeast cells by 0–90% at various glucose concentrations (5, 10, and 25 mM). Metformin was used as a standard reference. At all glucose concentrations, the highest concentration of WCME (5 mg/ml WCME) demonstrated maximum activity and showed the greatest increase (81.83 percent)...
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