Posted by admin on Apr 30, 2023 in |
Spilanthes acmella plant has been used for various purposes in traditional medicine since time immemorial. The present study aimed to determine the hepatoprotective activity of ethyl acetate extract of Spilanthes acmella in Paracetamol-induced hepatotoxicity in experimental animals. The leaves and flowers of this plant were used for this study, and the experiment was carried out in albino rats. The ethyl acetate extract at 100mg/kg and 200mg/kg body weight was evaluated by inducing hepatotoxicity with paracetamol at a dose of 2g/kg body weight and using Silymarin 100mg/kg as the standard reference drug. The hepatoprotective activity was monitored biochemically by estimating serum levels of AST, ALT, ALP, Total Protein, and Total and direct bilirubin. The extract exhibited significant (p<0.05) hepatoprotection in a dose-dependent manner in paracetamol-intoxicated albino rats. The hepatoprotective effects of the extract were comparable to the Standard drug, Silymarin, therefore suggesting further in-depth...
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Posted by admin on Apr 30, 2023 in |
The present study aims to develop and characterize colon-targeted mesalamine microsponges for treating inflammatory bowel disease, requiring long-term therapy. Mesalamine microsponges were prepared with different ratios of eudragit S100, by quasi-emulsion solvent diffusion method and evaluated. The drug release from in-vitro dissolution for all the prepared microsponges was extended to 12 hrs and above, and release kinetics followed a biphasic pattern with Higuchi non-fiction diffusion predominantly. SEM images clearly showed drug entrapment effectively in the microsponges based on the % yield, entrapment efficiency, drug content, and complete drug release (12-15 hrs). Microsponges prepared with a drug-to-polymer ratio of 5:1 (ES5) were considered suitable formulations. Microsponges were equivalent to a dose of 500 mg and were compressed into core tablets by direct compression. All the tableting parameters complied with the official compendia test for tablets as per IP. As the compression of the microsponges did not alter the release, tablets were further subjected to compression coating with cellulose acetate phthalate for colon targeting. From in vitro dissolution studies, drug release...
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Posted by admin on Apr 30, 2023 in |
The rapid rate of mutation of the RNA genome of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is responsible for the emergence of viral variants, leading to the enhanced survivability of the virus. Hence, searching for new drugs that can restrict new viral infections by interacting with wild-type and mutated viral proteins is important. However, new drug development’s economic and time-constraining nature makes ‘drug repurposing’ a more viable solution to address the problem. In this work, we conducted a computational study to screen 23 Non-Steroidal Anti-Inflammatory Drugs (NSAID) interactions with 5 major viral proteins of SARS-CoV-2 that are mainly involved in host infection. Our in-silico results establish a database that shows that different NSAID ligands interact with the different viral proteins with good binding affinities. Stabilizing point mutations were introduced within the conserved amino acids involved in ligand-protein interactions. Redocking the NSAID ligands with these mutated viral proteins showed that the NSAID ligands could bind with the mutated and wild-type viral proteins with comparable binding affinities. We conclude that...
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Posted by admin on Apr 30, 2023 in |
The efficacy of aescin on the liver and cardiac markers, lipid profile, and antioxidant status in rats with myocardial infarction (MI) induced by isoproterenol (ISO) was investigated in this study. Three doses of aescin (5, 10, and 20 mg/kg of b.w) were administered to rats for the first 21 days. After the treatment period, ISO (60 mg/kg of b.w) was given subcutaneously to the rats on the 22nd and 23rd day. Cardiovascular and hepatic markers (CK, ALT, CK-MB, AST, cTnI, and cTnT) has been analyzed to investigate cardiac and liver damage. The activities of antioxidant enzymes (CAT, GST, SOD, and GPx) were decreased in both cardiac tissue and erythrocytes of ISO rats. The levels of phospholipids (PLs), total cholesterol (TC), free fatty acids (FFA), and triglycerides (TG) were increased significantly in the serum of the rats administrated with ISO. The results of the present study implies that aescin pretreatment reduces oxidative stress and exhibits cardioprotective action by scavenging the free radicals and maintaining the levels of circulatory and cardiac...
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Posted by admin on Apr 30, 2023 in |
The study’s objectives were to create a pure herbal shampoo, assess its physicochemical qualities, and compare them to those of commercially available synthetic shampoos. The formulation of the herbal shampoo involved combining readily accessible at-home extracts of Reetha, Henna, Neem, Amla, almond powders, Alovera gel and tulsi lemon juice to a 10% aqueous gelatin solution. The pH was then corrected with citric acid. Nine distinct formulations were created using various amounts of each herb’s extract. To ascertain the physicochemical characteristics of both produced and marketed shampoos, a number of tests including visual inspection, pH, wetting time, percentage of solid components, foam volume and stability, surface tension, detergency, filth dispersion, etc., were carried out. By giving 20 student volunteers a blind test, the conditioning effect of the herbal shampoo formulation was also assessed. The herbal shampoo was presented simply and appealingly. After 5 minutes, it demonstrated strong detergency and cleaning, low surface tension, tiny bubble size, and good foam stability. The homemade and store-bought shampoos displayed comparable findings for the...
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