Posted by admin on Jan 31, 2023 in |
Acacia Arabica Willd.(syn: Acacia nilotica) is a thorny tree belonging to the family Fabaceae and subfamily Mimosoideae. Gum acacia, an exudation obtained from this plant, is included in the GRAS category and used widely as pharmaceutical aid. The plant contains flavonoids, tannins, and phenolic compounds as its phytoconstituents. The plant possesses antioxidant, antipyretic, antimicrobial, antiviral, antifungal, spasmolytic, antibacterial, hypoglycaemic, antifertility, immune-modulatory, hepatoprotective, hypotensive, and wound healing properties. The present study was done for the assessment of macroscopic characters, microscopic characters and physicochemical parameters. The chemical evaluation was done to identify the identification of active constituents of the plant. Other standardization methods like ash values, extractive values, and moisture content were estimated as per the standard process prescribed in IP. Heavy metal, aflatoxin, microbial contamination, and pesticide residue have also been calculated per the WHO guiding principle. A. arabica is brownish red, cylindrical with fibrous texture, hard to break, and rough to touch. Microscopic characters showed the presence of epidermis, collenchyma, vessels, medullary rays, xylem cells, calcium oxalate crystals, and...
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Posted by admin on Jan 31, 2023 in |
Generic medicines have the same efficacy, route of administration, strength, indication and side effects as branded medicines. In spite of the lower price, generic medicines are not popular among healthcare professionals. The study’s objective was to explore knowledge, practice and experience in using generic medicines among patients, common people, & healthcare professionals (nurses, pharmacists and doctors). It was a descriptive cross-sectional study. Data analysis i.e. statistical testing for significance was carried out using SAS® 9.4 software. Considering data of N=605 participants, several data analyses were performed. Among all participants, 97% were heard about generic medicines. 50% of participants not agree with that “Generic medicines are trusted by BA/BE study”. Among participating doctors, 58% were not aware about BA/BE study on generic medicines. 27% of participants did not agree with that “performances of generic medicines are same as branded medicines”. 23% were not agreeing with that “Generic medicines are safe as branded medicines”. 89% of participants agreed, “Price of generics lower than the branded medicines”. 66.8% of participants not get...
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Posted by admin on Jan 31, 2023 in |
Dapagliflozin and Metformin HCl Combination is the novel SGLT2 inhibitor used to control Hyperglycemia in type 2 diabetes mellitus. A literature survey reveals that various Analytical methods have been developed for Dapagliflozin in single and combined with other drugs. No QbD-assisted RP-HPLC method is available to estimate Dapagliflozin and Metformin HCl in combination. So, present work describes the development and validation of QbD driven RP-HPLC method for Dapagliflozin and Metformin HCl. The RP HPLC method has been developed using Agilent 1200 series HPLC with Intersil ODS column (250 x 4,6mm, 5 µm). Based on the RP-HPLC method, development Flow rate and pH were selected as CAA and Resolution, Retention time and Tailing of Drug were monitored using Design Expert@13.00. By applying CCD, 9 trials, 2 factors and 3 responses method had been selected for method development for Dapagliflozin and Metformin HCl. The optimum method development was selected based on the criteria of attaining appropriate Resolution, Tailing, and retention time. The overlay plot of responses generates an optimized area as...
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Posted by admin on Jan 31, 2023 in |
The gut microbiome composition directly correlates with the disease’s development and thus with an individual’s health. According to the published scientific literature, gut microbiota is directly linked with developing diseases such as colorectal cancer. On the other hand, Bacteriophages are the group of viruses that infects the bacterial cells typically and can be utilized to manage the dysbiosis of the gut’s microbial population. Here the major focus of this review is to know the applications and processes of bacteriophages in modulating the gut microbiome. According to studies, the modulation of the gut microbiome using bacteriophages has yielded good results. Although a major issue using this technique to modify the gut microbiome is regarding the survival of the phages when coming in contact with the stomach’s highly acidic environment. Consequently, effective phage encapsulation is required. Thus, in this review, we focus on treating colorectal cancer using bacteriophage-mediated modulation of the gut...
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Posted by admin on Jan 31, 2023 in |
This work aimed to evaluate the diuretic activity of Imperata cylindrica (Poaceae) leaves on rat. The extract was administered orally at doses 100, 200 and 400 mg/kg. The 24h urine volume and its pH were measured, natriuresis and kaliuresis were dosed. The results show that I. cylindrica increases diuresis, natriuresis and kaliuresis, but doesn’t affect urine pH. Diuresis of 24 h urine increases from 3.23 ± 0.32 ml in control group, to 5.33 ± 0.38, 6.83 ± 1.23 and 75 ± 1.32, respectively, in rats treated with the extract (P<0.05). Natriuresis increases from 1.21 ± 0.52 mEq/L to 2.38 ± 0.20, 3.15 ± 0.11 and 5.46 ± 0.72 mEq/L (P<0.05). Kaliuresis increases from 0.51 ± 0.71 mEq/L to 0.73 ± 0.65, 1.21 ± 0.51 and 1.75 ± 0.36 mEq/L (P < 0.05). The pH does not change, it is 8.52 ± 1.59 in control group and 8.51 ± 1.59, 8.47 ± 1.57 and 8.49 ± 1.58, in groups treated with the extract (N.S). These results show that Imperata cylindrica...
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