Posted by admin on Dec 31, 2022 in |
To solve the problem of low drug availability in the body, acyclovir was fabricated into biodegradable gelatin nanoparticles by step-wise two-times desolvation method where gelatin was used as biodegradable polymer and glutaraldehyde was utilized as a cross-linking agent. Optimization was conceded by design expert computational application whereby the outcome of gelatin polymer concentration (X1) and glutaraldehyde-crosslinking agent (X2) were studied on particle size (Y1), zeta potential (Y2), and entrapment efficiency (Y3). The drug-loaded gelatin nanoparticle formulations were characterized by particle size, surface charge, and entrapment efficiency. ANOVA studies also evaluated drug-loaded gelatin nanoparticles. The optimized formulation (F9) of 0.8% gelatin polymer (X1) and 250 μl of glutaraldehyde-crosslinking agent (X2) containing acyclovir: gelatin ratio of 1:8, which showed a particle size, zeta potential and maximum entrapment efficiency of 139.87 nm, -32.67mv and 91.23%...
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Posted by admin on Dec 31, 2022 in |
Anustrca annlipes (fiddler crab), often called crab, are decaped crustaceans of the uca family. They belong to the ocypodidae family, which contains over a hundred species of semi-terrestrial sea crabs. 11 of the 13 genera in the ocypodidae crab family are made up of more than 100 fiddler crab species. The species can be found on sea and brackish intertidal mud flats, lagoons and swamps, mangroves, salt marshes, and sandy or muddy west coasts. Anustrca annlipes also promotes the turnover and mineralization of critical nutrients and several species-specific body colour patterns that can act as intra- and intra-specific signals. Compared to female and smaller male uca annulipes crabs, they excavate their tunnels. An antimicrobial is a substance that kills or inhibits the development of bacteria. Antimicrobial medications are classified based on the bacteria they predominantly target. Through review number of antimicrobial proteins from Anustrca annlipes were identified. So the antimicrobial protein enolase from Anustrca annlipes sequence was retrieved from NCBI databases. Gene annotation was carried out by using amigo...
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Posted by admin on Dec 31, 2022 in |
The present study is designed to enhance the aqueous solubility of diclofenac sodium. For the said purpose co-crystal employing chitosan with diclofenac sodium is prepared by solvent exchange. The prepared co-crystal was characterized by FTIR, DSC, XRD and TGA studies. Further, solubility, anti-inflammatory activity and in-vitro release study was determined for different batches of the formulation. The solubility of different bathes of co-crystal was found to be between 34.6 to 46.6µg/ml as compared to the pure drug having a solubility of 18.6 and a physical mixture of 30.9µg/ml. The in-vitro release is found to be 72.5 to 84.8%, whereas PM shows 58.7 % release and pure drug shows 27.8 % release. The in-vitro release data of the optimized batch followed fickian diffusion mechanism. The % inhibition of formulation co-crystal is much more than the model drug (diclofenac sodium). Thus, the diclofenac-loaded co-crystal would be useful for delivering poorly water-soluble drugs with enhanced dissolution, solubility and improved anti-inflammatory activity of the...
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Posted by admin on Dec 31, 2022 in |
Introduction: Scapulae bear a shallow articular concave fossa commonly known as glenoid cavity that accommodates the head of the humerus to form a shoulder joint. The size and shape of glenoid fossa is highly variable; hence, knowledge about morphological measurements is invariably essential for surgery and artificial prosthesis pertaining to shoulder joint pathology. Aim: Glenoid fossa morphometry to study its various shapes and diameters in dry human scapulae. Materials and Methods: Dry bone scapulae were obtained from the bone room of the post-graduate department of Anatomy S.C.B Medical College Cuttack. Ninety-seven samples were studied, out of which 45 belonged to the right side and 52 left sides. All the measurements were carried out by verniers caliper for the height of glenoid fossa (A =A1+ A2) and breadth (B = B1+B2). A Goniometer measured the glenoidal version. Observation: The oval shape was the most common glenoid fossa observed, amounting 42(43.3%). The mean value for length with Standard Deviation was 31.5±3.16 millimeters and the mean and standard deviation Breadth was 21.99±2.76...
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Posted by admin on Dec 31, 2022 in |
The objective of this study is to investigate the protective effect of aqueous bark extract of Terminalia arjuna (TA) on high-fat diet-induced cardiovascular changes in Wistar rats using histological, immunohistochemical, and gene expression analysis. Group 1- without treatment served as control, group 2- High fat diet (HFD) received corn oil orally at a dose of 10 mL/kg, group 3 – HFD+atorvastatin (ATV) – 10 mg/kg, group 4 – HFD+TA125 mg/kg , and group 5- HFD+TA250 mg/kg, 6 days a week for 5 weeks. The activity of MMP-9 was measured in blood, Hematoxylin and Eosin staining was analyzed with heart tissue and TNF-α immunohistochemistry and ADIPOQ gene expression analysis were conducted using heart tissue. When Compared to the control group, the HFD group showed higher levels of MMP-9 activity and morphological changes in heart histology. TNF-α expression was also significantly increased in HFD group and down-regulation of ADIPOQ gene expression levels. MMP-9 activity and pathological damage to cardiac tissue including ADIPOQ gene expression were significantly reverted when T. arjuna bark...
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