Posted by admin on Oct 31, 2022 in |
Dexibuprofen is a Non-Steroidal Anti-Inflammatory Drug. It indicated short-term management of mild to moderately severe acute pain, dental pain, dysmenorrhoea, muscular pain and osteoarthritis. In the prevailing work, studies have been carried out on the preparation and in-vitro characterization of matrix tablets of dexibuprofen using different polymers like hydrophilic and hydrophobic. Different formulations had been prepared by wet granulation method using various release retarding polymers like methylcellulose, xanthan gum, and sodium carboxymethyl cellulose. Water-soluble surfactant sodium lauryl sulfate was employed to enhance the solubility of the dexibuprofen. Drug-excipients compatibility became performed by way of FTIR. Different parameters were evaluated for hardness, thickness, friability, drug content material, and in-vitro drug release. The excellent consequences were determined in terms of physicochemical parameters. The 10 numbers of formulations have been discovered to display the highest drug release of the drug. Mathematical analysis of the release kinetics has been accomplished to determine the mechanism of drug release. In-vitro release records have been fitted into diverse models to envision the kinetic of drug...
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Posted by admin on Oct 31, 2022 in |
Heavy metal toxicity has been a subject of concern for the past few decades. Due to the emerging awareness about the detrimental health hazards and adverse effects across all the levels of any ecosystem, the removal of heavy metals (HM) from contaminated water systems and soil has gained the profound attention of the scientific community for the last couple of decades. Living and dead cells of biological organisms have found to have capable of retaining the harmful HMs substantially from aqueous and solid matrix. This review encompasses the efficacy of cyan bacterial cells in removing HMs from contaminated water and wastewaters. The different strains collected from different sources which are capable of removing specific species have been discussed along with the biotic and biotic factors affecting the process have been assessed. Also, the mechanism of toxicity and removal of HMs through biosorption and bioaccumulation by these cells have been taken into consideration. The thorough knowledge of the cyanobacterial removal of HMs can be a solution towards sustainable, cost-effective green...
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Posted by admin on Oct 31, 2022 in |
Objective: Rheumatoid arthritis (RA) is a systemic disorder which involves the activation of immune system against the self-tissues. The main targets of this disease are the joints. Being systemic, the development of this disease involves different mechanisms, and thus, the exact cause of this disease remains unknown. Although different drugs have been developed, none has been found to be the cure for this disease. The present study was commenced to evaluate the in-vivo anti-arthritic effect of polyherbal formulation of selected plants Polygonum glabrum, Canthium dicoccum, Ochna obtusata and Argyreia nervosa. Materials and Methods: In-vivo anti-arthritic activity of the ethanolic extract of different portions capsule formulation F4 investigated orally was assessed using complete Freund’s adjuvant-induced arthritis. Results: In complete Freund’s adjuvant-induced arthritis models, the polyherbal extract formulations significantly (P < 0.001) reduced joint and paw swelling and markedly improved body weight, hematology profile, and parameters in complete Freund’s adjuvant model. Conclusion: It could be concluded that the ethanolic extract of two different formulations holds anti-arthritic potential, supporting its traditional use...
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Posted by admin on Oct 31, 2022 in |
Antibacterial activity of five marine microalgae Isochrysis galbana, Chaetoceros calcitrans, Tetraselmis suecica, Nannochloropsis oculata, Aphanocapsa sp. was studied from Visakhapatnam. The ethanolic extract of T. suecica, C. calcitrans, and N. oculata s howed inhibitory activity against V. harveyi and S. Aureus with inhibition zone between 11.5 and 20mm. The ethanolic extract of I. galbana showed inhibitory activity against S. aureus only with an inhibition zone of 15mm. Among the four extracts, T. suecica showed maximum inhibitory activity against V. harveyi with an inhibition zone of 20mm. The methanolic extract of T. suecica moderately inhibited the growth of V. harveyi and S. aureus with inhibition zones of 11.5 and 11 mm respectively, whereas the extracts of I. Galbana and C. Calcitrans inhibited only V. harveyi with inhibition zones of 10 and 12 mm respectively, but no activity was found against S. aureus, A. hydrophila and E. coli. So, the studied microalgae could be used as a potential source to extract, bioactive marine natural compounds with antibacterial activity....
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Posted by admin on Oct 31, 2022 in |
Leclercia adecarboxylata is a gram-negative bacillus. L. adecarboxylata has been isolated from various environments, such as food and water, and clinical specimens from patients with various diseases and ailments, such as pyelonephritis and sepsis. Although L. adecarboxylata infections are generally treated with β-lactam antibiotics, the emergence of multidrug-resistant strains reported in recent years has presented a major challenge in the clinical treatment of the infections. Thus, I searched for potential candidate compounds for developing new antibiotics that are effective against multidrug-resistant L. adecarboxylata. In a docking simulation performed to extract an inhibitor of the molecular chaperone GroEL, mizoribine was identified as a “hit.”Notably, when L. adecarboxylata was cultured in a mizoribine-containing medium, its growth was inhibited at mizoribine concentrations of ≥0.63 mmol/L. considering these findings, I propose that mizoribine could serve as an effective new therapeutic agent for L. adecarboxylata infection. In the future, it will be necessary to investigate the effects of mizoribine on other bacterial...
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