Posted by admin on Sep 30, 2022 in |
The current study aimed at investigating the phyto-chemical constituents, in-vitro antioxidant activity and in-vivo acute oral toxicity of Banana inflorescence (blossom) of Musa acuminate. All the experiments were conducted using standard procedures. The results of the phytochemical screening revealed the presence of different types of secondary metabolites like alkaloids, phenols, saponins, flavonoids, steroids, tannins, and glycosides. The acute toxicity study was conducted in Wister albino rats. The Banana inflorescence was administered as a single dose of 2000 mg/kg body weight and observed the behavioral changes and mortality rates. In this study, no visible behavioral changes and mortality observed up to 2000 mg/kg of the Wister albino rats. The antioxidant activity of Banana inflorescence was evaluated by DPPH free radical scavenging assay. Rutin was used as a reference compound. The IC50 value of Banana inflorescence was found to be 46.47372 % and the standard rutin was 27.69024%. We conclude that Banana inflorescence extract did not exhibit any toxic effects on mice. This extract also possesses many phytochemicals and significant antioxidant activity. Therefore, Banana...
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Posted by admin on Sep 30, 2022 in |
Alzheimer’s disease, the most common form of dementia, is higher in elderly women than men. Escape latency time of Group 3 (Donepezil) and Group 6 (AMEE and Estradiol) is less than group 2 (Scopolamine and letrozole). As shown by the results, the decrease in AChE level in Group 3 (Donepezil) and Group 6 (AMEE and Estradiol) indicates restoration of Ach level in the brain. Increased GSH level was seen in Group 3 (Donepezil) and Group 6 (AMEE and Estradiol16 indicating antioxidant property. The architecture of the neurons in the hippocampus histopathological studies was seen when the combined treatment with estrogen and AMEE was given confirming that our given combination has the potential to improve memory in female rats, particularly those who were estrogen-deficient as in our experimental design. Based on our experiments, we can conclude that Aegle marmelos ethanolic extract, along with estradiol, can improve memory and can be used for further studies in this...
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Posted by admin on Sep 30, 2022 in |
Mustard seeds, in some countries, are used as a traditional medicine for the treatment of snakebite, toothache, and epilepsy, as well as to treat skin diseases because of their high sulphur content. The aim of this study was to investigate the effect of three germination periods on the polyphenol contents and antioxidant activity of mustard seeds. Phenolic compounds were determined by the Folin-Ciocalteau method, while antioxidant activity was determined using standard methods. The results indicated that the total phenol and flavonoid contents of the one, two, and three days germinated mustard seed were increased by 16%, 17%, 24% and 500%, 647%,747%, respectively. Antioxidant activity determined by reducing power assay (for one, two and three days of germinated mustard seed) also increased by 10%, 34%, 51%, respectively. Germination is thus a better technique to enhance the nutritional and pharmaceutical potential of mustard seed and can be used in the development of functional...
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Posted by admin on Sep 30, 2022 in |
Iron overload has toxic effects on the body. Hepatotoxicity is a common finding in iron-overloaded patients, resulting from iron deposition in hepatocytes. Angiotensinɪɪ is involved in developing hepatic damage through its pro-oxidative properties. Therefore, the current study aimed to investigate the therapeutic effect of the ACE inhibitor, lisinopril, against ferrous sulfate-induced hepatic functional disorders and histological damages in rats, due to its inhibitory effect on angiotensin II and its ability to scavenge free radicals in-vitro. 23 male adult rats were randomly classified into three groups and treated as follows: Normal control group: received daily 1 ml/day distilled water as an intraperitoneal injection for 14 days, Iron overload non-treated group: received ferrous sulfate at a daily dose of 30 mg/kg/day i.p. for 14 days, Iron overload treated with lisinopril group: received ferrous sulfate at a dose of 30 mg/kg/day followed by lisinopril at a dose of 1 mg/kg/day daily i.p. for 14 days. Compared to the control group, administration of ferrous sulfate resulted in liver dysfunction, as evidenced by significantly...
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Posted by admin on Sep 30, 2022 in |
Proximate composition, qualitative screening for phytochemicals (terpenoids, steroids, tannins, oxalates, coumarins, phenols, saponins, and flavonoids) and antioxidant properties in four selected indigenous oilseeds: morama (Tylosema esculentum), mongongo (Schinziophyton rautenenii), mogose (Bauhinia petersiana) and kgengwe (Citrulus lanatus (Thunb.) Mansf.) from Botswana was examined. A significant difference (p≤0.05) was observed in the moisture, fat, protein, ash, carbohydrate, and energy contents. The values ranged from 3.87 – 7.27, 15.99 – 57.70, 12.44 – 33.76, 3.07 – 6.07, and 6.31 – 60.01%, respectively, while the range for the energy content was from 422.35 to 655.29 kcal/100g. Only oxalate was not detected in the qualitative tests performed for eight (8) phytochemical compounds with six (6) solvent extracts. The highest total phenolic content was recorded in morama seeds (1.72 mg GAE/mL), while total flavonoids were better in mogose (0.00813 mg CE/g) and kgengwe (0.00404 mg CE/g). The vitamin C equivalent antioxidant capacity (VCEAC) for mogose, morama, and kgengwe were 2.39, 2.07, and 0.78 mg/100 g, respectively. The study indicated that the oilseeds could potentially be...
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