Posted by admin on Nov 30, 2022 in |
Plants have been utilized as medicine since the ancient period, and they are at the basis of much of modern medicine. Plants provide the basis for many conventional medications and the majority of the few successful drugs. Herbal formulations are becoming increasingly popular nowadays. But in some cases, side effects of the herbal formulations have been reported. So, according to the AYUSH ministry, herbal formulations should also be evaluated for toxicity to determine their safe dose. This study aims to critically assess the scientific evidence for herbal formulations’ acute and subchronic toxicity. Six herbal formulations of Shree Dhanwantri Herbals were tested for toxicity in rats. An acute and subchronic toxicity study was conducted on Wistar rats following OECD-423 and OECD-408 guidelines, respectively. No mortality or abnormal behavior was observed in the acute toxicity studies. In the sub-chronic toxicity study, testing formulations did not produce any significant changes in rats’ behavior compared to the control group. Further, hematological and biochemical parameters were also found normal. Histopathological analysis revealed that treated...
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Posted by admin on Nov 30, 2022 in |
A metabolic disease called diabetes mellitus in which blood glucose levels are abnormally high. It could be due to tissue glucose intolerance and impaired insulin production. In a Type II diabetes model generated by Streptozotocin and nicotinamide, the antidiabetic potential of ethanolic and aqueous leaf extracts of Michelia champaca (Magnoliaceae) was compared to a control group of diabetes. The anti-diabetic activity was tested on Wistar rats. The effective antihyperglycemic ethanolic and aqueous leaf extracts were tested at two doses of 250 mgkg-1 b.w. and 500 mgkg-1 b.w. for 21 days. Compared to the diabetic control group, the ethanolic extract at a dose of 500 mgkg-1 b.w. exhibits a highly significant (p<0.001) reduction in fasting blood glucose levels. After the trial, the blood sample was drawn from all animals for biochemical analysis. In extract-treated diabetic rats, the serum lipid profile was calculated. The biochemical investigation, serum cholesterol, serum triglyceride, high-density lipoprotein, and low-density lipoprotein support the ethanolic extract’s anti-diabetic...
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Posted by admin on Nov 30, 2022 in |
The purpose is to formulate the solid self emulsifying drug delivery system (S-SEDDS) to improve poor aqueous solubility and dissolution of ciprofloxacin. A solubility study was carried out, and then Soyabean oil (as oil phase), Tween 20 (as surfactant), and Span 80 (as co-surfactant) were selected for preparation of emulsion by titration method. Adsorption to solid carrier technique was used for solid SEDDS, areosil (Colloidal silica) used as adsorbent. In that formulation, I was having carbopol 934 and another formulation II HPMC K 4 M. The flow properties of all formulation were within the acceptable range; therefore, they can be easily filled into capsule. IR spectral and DSC thermograph analysis showed that there was chemical interaction between drug and polymer. In-vitro release studies were carried out in phosphate buffer pH 7.4. Release profile of pure drug formulation showed 38%, formulation I showed highest 54% cumulative drug release and formulation II showed lowest i.e. 14% drug release. Student’s t-test was determined for In-vitro drug release data for different polymeric formulations...
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Posted by admin on Oct 31, 2022 in |
The objective of present study was to develop extended release microspheres of quetiapine fumarate using Eudragit RS 100 and Eudragit RL100 to reduce the dosing frequency. The quetiapine fumarate-loaded Eudragit microspheres were formulated by a solvent evaporation method. A 32 factorial design was employed to study the effect of concentration of sodium lauryl sulfate (SLS) and drug: polymer ratio on percentage yield, percentage entrapment efficiency, particle size, and % in-vitro drug release at 10 h. Drug excipients compatibility study by DSC showed no interaction between drug and excipients. The entrapment efficiency was found to be 40.56 ±1.32 % to 72.66 ±2.13 %, and the particle size range was 165±3.51 µm to 243±3.05 µm. In-vitro drug release of quetiapine fumarate microspheres showed a sustained release up to 24 h. Concentration of SLS and drug: polymer ratio had significant effect on % yield, % entrapment efficiency, particle size and % in-vitro drug release. From all parameters and experimental design evaluation it was concluded that drug release rate decreased with an increase...
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Posted by admin on Oct 31, 2022 in |
Dexibuprofen is a Non-Steroidal Anti-Inflammatory Drug. It indicated short-term management of mild to moderately severe acute pain, dental pain, dysmenorrhoea, muscular pain and osteoarthritis. In the prevailing work, studies have been carried out on the preparation and in-vitro characterization of matrix tablets of dexibuprofen using different polymers like hydrophilic and hydrophobic. Different formulations had been prepared by wet granulation method using various release retarding polymers like methylcellulose, xanthan gum, and sodium carboxymethyl cellulose. Water-soluble surfactant sodium lauryl sulfate was employed to enhance the solubility of the dexibuprofen. Drug-excipients compatibility became performed by way of FTIR. Different parameters were evaluated for hardness, thickness, friability, drug content material, and in-vitro drug release. The excellent consequences were determined in terms of physicochemical parameters. The 10 numbers of formulations have been discovered to display the highest drug release of the drug. Mathematical analysis of the release kinetics has been accomplished to determine the mechanism of drug release. In-vitro release records have been fitted into diverse models to envision the kinetic of drug...
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