Posted by admin on Sep 30, 2022 in |
Diabetes mellitus, a metabolic disorder, is a serious universal health problem. The incidence of the disease is increasing in the world in all ethnic groups. Various medicinal plants are conventionally used in the treatment or management of the disease. In this investigation, an attempt was taken to evaluate the antidiabetic property of hydroalcoholic extract of leaves of Nyctanthes arbortristis in various rat models such as normoglycemic rats and glucose-loaded rats, adrenaline-induced hyperglycemic rat models as well as alloxan-induced diabetic rats. The extract exerted a significant (P<0.05) hypoglycemic effect at a dose of 200mg/kg on normoglycemic rats for 5 hours. The extract improved glucose tolerance significantly (P<0.05) in comparison to the control (2 gm/kg p.o. glucose) group. The extract significantly (P<0.05) decreased blood glucose concentration in adrenaline (0.8 mg/kg, i.p) treated rats. The extract also significantly (P<0.05) lowered blood glucose levels in alloxan-induced rats. The antidiabetic property of leave extract was comparable to Glibenclamide (standard drug) 0.5 mg/kg p.o. dose. Therefore, this study, “Antidiabetic Potential of Hydroalcoholic Extract of Leaves...
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Posted by admin on Sep 30, 2022 in |
Purpose: Formulation and evaluation of the herbal gel preparation from the thorn’s extract of Bombax ceiba to check its antibacterial activity against the bacteria Staphylococcus aureus and Propionibacterium acnes Methods: Agar well diffusion method was employed for this purpose. Results: Gel formulation of different concentrations of extract were formulated that is 2%, 4%, 6%, and 8%, respectively, and antibacterial activity of the gels was measured against the bacteria Staphylococcus aureus and Propionibacterium acnes. In this clindamycin gel was used as the standard for comparative analysis. From evaluation results, it was concluded that the formulation of 8% showed better antibacterial activity as compared to other formulated preparations. In addition to this, an evaluation of gel formulations was performed considering various parameters, which were pH, appearance, viscosity, spreadability and homogeneity and the result were calculated. Conclusion: The ethanol thorn’ extract of Bombax ceiba possesses good antibacterial properties against the Staphylococcus aureus and Propionibacterium acnes. It also contains various phytoconstituents, which may be helpful in various health-related...
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Posted by admin on Sep 30, 2022 in |
Transferosomes are a special liposome type consisting of phosphatidylcholine and an edge activator. Glimepiride is a second-generation sulphonylurea exerting its effects in patients with type II Diabetes. Glimepiride is hydrophobic in nature possess less solubility and permeability. The study aims to formulate, optimize and evaluate Glimepiride Transferosomal gel for antidiabetic activity in Rats. Glimepiride loaded Transferosomes were prepared using thin film hydration method and were optimized using factorial design (32) using Design-expert® software (Version 7.0.0, Stat-Ease Inc., Minneapolis, USA); different formulations (F1-F9) were prepared. Two different independent variables were used, which include: Amount of Soya lecithin (X1), Amount of tween 80 (X2), and the responses are Entrapment Efficiency (Y1), vesicle size (Y2). The optimized formulation of Glimepiride transferosomes was incorporated into a Carbopol 934 gel base and 1.5 % of Glimepiride transferosomal gel was prepared, which was evaluated for drug content, pH, spreadability, viscosity and in-vitro drug release. The prepared Glimepiride transferosomes had a maximum EE% was found to be (73.25 %), particle size was found to be (323...
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Posted by admin on Sep 30, 2022 in |
Background: Injudiciously use of antibiotics / antimicrobial agents poses a major public health threat worldwide. Medical students will be future prescriber of antimicrobial agents so they need to have a wide awareness of the use and resistance of antibiotics. Therefore, this study was planned to assess the Knowledge, Attitude and Practice (KAP) toward antibiotics usage and antibiotics resistance among medical students of JLN Medical College, Ajmer, Rajasthan, (India). Methods: This descriptive and cross-sectional study was conducted in 255 medical students of JLN Medical College, Ajmer, Rajasthan. A validated questionnaire comprised of 20 questions, in which 10 in the knowledge section, 5 each in attitude and practice section was provided in November 2021.data were analyzed by using descriptive statistics after entering them into a Microsoft Excel sheet. Results: 94.12% knew that inappropriate uses of antibiotics agents might promote antibiotics resistance. 90.98 % of participants were aware that self-medication can make a contribution to antibiotics resistance. Students showed good knowledge about the use and resistance of antibiotics. 89.41% of participants showed...
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Posted by admin on Sep 30, 2022 in |
Background: Diabetes mellitus is one of the most common metabolic disturbances associated with carbohydrates, lipids, proteins, and relative or absolute insulin depletion. Various long-term complications of diabetes develop due to chronic hyperglycemia and insulin resistance. Chronic kidney disease (CKD) and diabetes mellitus (DM) are major public health problems worldwide. Turmeric is one of the medicinal herbs studied for antioxidant, antibacterial, and antifungal effects. Curcumin has been established to be defensive against nephropathy. Objective: The purpose of this study was to assess turmeric’s effect on different kidney function parameters in patients with type 2 diabetes mellitus (T2DM). Materials and Methods: Two hundred patients with T2DM were selected in randomized control trial, of which 100 subjects were enrolled in the study group, were given 500 mg of raw turmeric powder in capsule form daily along with their antidiabetic drug medication (Metformin) for 3 months period while 100 subjects on medication of antidiabetic drug (Metformin) were selected as a control group. Serum levels of urea, creatinine, total protein, albumin, and globulin were...
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