Posted by admin on Jan 31, 2025 in |
Background: Drug-induced gingival overgrowth (DIGO) is a common side effect of certain medications used for non-dental purposes, notably anticonvulsants, calcium channel blockers (CCBs), and immunosuppressants. These drugs, despite differing pharmacologically, inhibit intracellular calcium ion influx, leading to a decrease in collagenolytic activity and an increase in fibroblasts and collagen synthesis, ultimately causing gingival overgrowth. Case Presentation: A 54-year-old male presented with significant gingival enlargement and periodontal disease. Clinical examination revealed generalized mild to moderate calculus, erythematous and indurated gingiva with severe periodontal attachment loss, and tooth mobility. Despite scaling and root planning, the gingival enlargement persisted, necessitating surgical intervention. Open flap debridement was performed, leading to a successful outcome with no recurrence of gingival enlargement after one year of follow-up. Discussion: The case highlights amlodipine-induced gingival overgrowth, a recognized side effect of CCBs. The exact mechanisms remain unclear, with both inflammatory and non-inflammatory pathways implicated. The inflammatory process involves cytokine upregulation, leading to fibroblast proliferation and fibrotic gingival hyperplasia. The case underscores the importance of early diagnosis, medication management,...
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Posted by admin on Jan 31, 2025 in |
Background: There are numerous anti-seizure drugs on the market, but side effects at the highest dosage that can be tolerated account for the majority of prescription discontinuations. Research on Musa paradisiaca’s synergistic activity is of utmost importance in getting insight into its anti-seizure potential. Methods: Anti-seizure activity of Musa paradisiaca on generalized tonic-clonic seizure was evaluated using standard maximal electroshock seizure method and on absence seizure using pentylenetetrazole test. Both models had 6 groups each: vehicle control, active control, high dose herb, low dose herb, combination of active control (sub-therapeutic dose) with low dose herb & combination of active control (sub-therapeutic dose) with high dose herb. Results: In MES model Musa paradisiaca in high dose prevented both tonic extension and tonic flexion. In PTZ model Musa paradisiaca in high dose and low dose significantly increase the latency of onset of seizures and decrease the duration of seizure compared to vehicle control. There was no significant effect on onset of 1st myoclonic jerk. Addition of Musa paradisiaca to the sub-therapeutic...
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Posted by admin on Jan 31, 2025 in |
Metabolic syndrome is continuously on the rise, due to a changed lifestyle and long ageing. The abnormal function of mTOR/AMPK, a cellular energy switch, is the main cause behind this pathogenesis, which is now defined as “metabolic syndrome”. Here, we have screened the metabolites of shilajit, obtained from the HRAMS analysis, to select the direct activators of AMPK, by using computational exploration, through molecular docking and ADMET prediction. The shilajit has been in clinical use in Ayurvedic medicine, for centuries, to enhance the overall vitality, immunocompetence and aphrodisiac potential, but scientific data are lacking to support its therapeutic claims. The shilajit, of Upakarma Ayurveda was purchased from the market and analyzed through HRAMS, which reported the presence of 5467 metabolites. Their CID numbers were obtained from the PubChem portaland docked against the AMPK (AMPK active site PDB ID-4CFF), by using LibDock and Discovery Studio to do a structure-based screening, ADME (absorption, distribution, metabolism, excretion) and toxicity prediction. Among them, Reproterol (CID-25654) and Ambruticin (CID-6918547) showed the best binding energy,...
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Posted by admin on Jan 31, 2025 in |
Modern breakthroughs in dentistry have created the opportunity for people to maintain a functional dentition for lifetime. Hemisection is a conservative approach of maintaining tooth. This is an endodontic treatment that involves removing one or more roots as well as the current crown structure in order to promote tooth retention and address nonfunctional dental roots that cannot be maintained. As they are prone to fracture it is critical to replace them using an extracoronal restoration. A 35-year-old male patient complaint of mild intermittent pain in relation to the lower left back tooth region since 15 days. The teeth were tender to percussion. A diagnosis of symptomatic irreversible pulpitis with symptomatic apical abscess with a treatment plan of hemisection in relation to #36 was made. 18 months clinical and radiographic follow-up depicts adequate radiographic healing, high lighting in achieving retention of mesial half of tooth structure and its supporting...
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Posted by admin on Jan 31, 2025 in |
An evergreen semiparasitic plant belonging to the Loranthaceae family, Dendrophthoe falcata (L.f.) Ettingsh is common throughout India and feeds on a variety of host species. The potential of silver nanoparticles (AgNPs) produced by D. falcata-mediated processes is still unknown, despite the known bioactivity of D. falcata extracts. The present investigation examines the phytochemical profile of leaf extracts from D. falcata, their function in the synthesis of AgNPs, and the AgNPs’ bioactivity. The existence of tannins, terpenoids, alkaloids, and flavonoids was verified by phytochemical analysis. AgNPs were synthesized and characterized using UV-Vis spectrophotometry, FTIR, SEM, TEM, and XRD, confirming their structural integrity and stability. The DPPH radical scavenging assay revealed AgNPs’ robust antioxidant properties by showing that their capacity increased proportionately with incubation time and that their purple coloring significantly decreased. Also, AgNPs proved robust antibacterial activity, comparable to positive controls against E. coli, a gram-negative bacterium. They showed a notable inhibition zone against gram-positive bacteria at a 300 μl concentration. Further, AgNPs inhibited S. aureus, albeit only at higher...
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