Posted by admin on Nov 30, 2025 in |
Background: Psychotropic medications are integral to managing psychiatric disorders; however, their associated adverse drug reactions (ADRs) can significantly impair patients’ quality of life (QOL). Objective: To evaluate the spectrum of ADRs linked to psychotropic drug use and assess their impact on QOL among psychiatric patients at a tertiary care centre. Methods: In this cross-sectional observational study, 105 patients from the psychiatry outpatient and inpatient departments of JLN Medical College, Ajmer, were assessed. ADRs were documented using standard Pharmacovigilance Programme of India (PvPI) reporting formats. The WHOQOL-BREF questionnaire evaluated QOL. Causality and severity of ADRs were determined using the WHO-UMC scale and Hartwig’s criteria, respectively. Results: A total of 264 ADRs were recorded, with slurred speech (35.2%), rigidity (18.1%), and tremors (17.1%) being the most frequent. Antipsychotics, particularly olanzapine (22.8%) and haloperidol (19%), were commonly implicated. Most ADRs were non-serious (91.4%) and classified as probable (54%) or possible (42%). Patients experiencing moderate-to-severe ADRs showed significant declines in physical (p=0.004) and psychological (p=0.008) QOL domains. Conclusion: ADRs from psychotropic medications adversely...
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Posted by admin on Nov 30, 2025 in |
Background: Thyroid dysfunction is a common endocrine disorder affecting women’s reproductive health, manifesting as menstrual irregularities and infertility. Regional data from Northwestern Rajasthan remain limited. Objective: To evaluate the association between thyroid dysfunction and menstrual disturbances and fertility outcomes in women attending a tertiary care hospital in Northwestern Rajasthan. Methods: A hospital-based cross-sectional study was conducted over 12 months, enrolling 300 women aged 18–45 years presenting with menstrual irregularities or infertility. Clinical examination, menstrual history, and thyroid function tests (TSH, FT3, FT4) were evaluated. Women were classified as euthyroid, hypothyroid, or hyperthyroid based on standard reference values. Statistical analysis was performed using SPSS v25.0. Results: Thyroid dysfunction was found in 60.3% of participants (hypothyroidism 48.6%, hyperthyroidism 11.7%). Menstrual disturbances, including oligomenorrhea (37.9%) and menorrhagia (25.2%), were significantly higher in the hypothyroid group (p<0.001). Infertility was more prevalent in thyroid-dysfunctional women (42.5%) than euthyroid women (17.8%, p<0.001). Subclinical hypothyroidism was the most common abnormality (28.7%). Conclusion: Thyroid dysfunction, especially hypothyroidism, significantly affects menstrual and fertility outcomes. Early detection and management...
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Posted by admin on Nov 30, 2025 in |
Background: Myristicin is a naturally occurring allyl benzene primarily obtained from various plants and spices like nutmeg, fennel, parsley and carrot. Herbs and spices abundant in Myristicin are utilized in traditional medicine to manage conditions like abdominal cramps, diarrhea, rheumatism, anxiety, fever, and halitosis. Nutmeg has been utilized as a mild sedative. Myristicin produces dose-dependent neurological effects. Methods: This experimental study was carried out in the Department of Pharmacology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India. This study examined the hypnotic effects of Myristicin in rats. The method utilized to evaluate the hypnotic effect of Myristicin was pentobarbital-induced sleep potentiation. Two oral dosages of Myristicin, 10 mg/kg as well as 20 mg/kg, were administered, with propylene glycol serving as normal control. Following 60 minutes of oral dosing, pentobarbitone (30 mg/kg) was given intraperitoneally to produce sleep. Sleep latency and duration of sleep were recorded for each rat. Results: The results showed that Myristicin at 10 mg/kg dose can significantly reduce the latency of sleep in...
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Posted by admin on Nov 30, 2025 in |
The present study was carried out to enhance the dissolution rate of poorly water-soluble drug Telmisartan, by solid dispersion technique using different carriers and super disintegrants by solvent evaporation method. Solid dispersions were prepared with mannitol and PEG 6000 in different ratios of 1:1, 1:3 and 1:5. In-vitro dissolution profile of solid dispersion (SD) with drug and mannitol in the ratio of 1:3 (SDM2) was found to be highest among all 12 formulations. This SD was further adsorbed with Neusilin US2 to form a ternary mixture. Crospovidone was used due to its promising role in dissolution enhancement of telmisartan based on previous studies. For optimizaton of concentration of Neusilin US2 and crospovidone in solid dispersion, Central Composite Design was applied for two factors at two level which gave 13 formulations. Tablets were prepared and evaluated for physiochemical properties. Reponse surface plot and contour plot were drawn, and an optimum formulation was selected. This formulation contained 40 mg of Neusilin and 14 mg Crospovidone (CCDF4). The in-vitro dissolution studies of...
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Posted by admin on Nov 30, 2025 in |
Diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels, with type II diabetes mellitus being the most prevalent form, primarily resulting from insulin resistance and/or insufficient insulin secretion. Mucoadhesive buccal patches, which are designed to adhere to the buccal mucosa for systemic effectiveness, offer a more effective option for oral administration because they bypass the first pass metabolism. Linagliptin, a dipeptidyl peptidase-4 (DPP-4) Inhibitor, is commonly used for the management of type II diabetes but suffers from limitations related to oral bioavailability and patient adherence. The present study aims to formulate and evaluate a Mucoadhesive buccal patch of linagliptin to provide sustained drug release and improve therapeutic effects. The primary objective Includes assessing the Mucoadhesive strength to ensure prolonged adhesion to the buccal mucosa, evaluating the formulation for pharmaceutical Suitability, and creating an ideal patch with desired physicochemical properties. The buccal patches were successfully developed with polyvinylpyrrolidone K30 (PVP K30) and hydroxypropyl methylcellulose (HPMC) as polymers using the solvent casting method, and the selected polymers...
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