Posted by admin on May 31, 2026 in |
Objective: The study was carried out to investigate the possible hypolipidemic and antioxidant properties of the shoot extract of Bambusa balcooa in experimentally induced hyperlipidemia in rabbits. Methods: Ethanolic extract of shoot of Bambusa balcooa (EELBB) was evaluated for hypolipidemic and antioxidant activities using 400 mg/kg body weight per day in a high fat diet induced hyperlipidemia in rabbits. The results were analyzed using one-way analysis of variance (ANOVA) followed by Bonferroni’s multiple comparison tests and compared to the normal control, experimental control and the standard drug (atorvastatin 2.1 mg/kg body weight per day) groups. The results were expressed as mean±standard deviation (SD). Values with p< 0.05 were considered significant. Results: Oral administration of EELBB resulted in decrease in Total Cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and a significant increase in the high-density lipoprotein cholesterol (HDL-C) when compared to the experimental control group. There were also significantly elevated catalase and superoxide dismutase (SOD) activities and significantly lower malondialdehyde (MDA) levels in the test group compared to the...
Read More
Posted by admin on May 31, 2026 in |
The study focused on the formulation, optimization, and evaluation of benidipine transdermal patches to overcome the drug’s low oral bioavailability and short half-life. FTIR analysis confirmed compatibility between benidipine and selected excipients (HPMC K-100, CMC, PEG-400, Tween-20), showing no significant peak shifts. Patches (F1–F12) were prepared by solvent casting with varying polymer concentrations and evaluated for physicochemical properties, all of which were within acceptable limits, indicating good uniformity and mechanical strength. In-vitro release studies showed an initial burst followed by sustained release for 48 hours, with F5 and F7 exhibiting superior drug release. Central Composite Design identified HPMC K-100 and CMC levels as key factors influencing drug release, moisture content, and permeation, with higher polymer concentrations decreasing release due to increased matrix density. Optimization selected F4 as the best formulation, offering controlled release, high drug content, and improved permeation, suggesting strong potential for sustained antihypertensive...
Read More
Posted by admin on May 31, 2026 in |
The present study was aimed at incorporation of Frankinsense oil in nanosponges based hydrogel for wound healing activity. The oil was incorporated in nanosponges by the emulsion solvent diffusion method using different combinations of hydrophilic polymers like HPMC K15M, Poly vinyl alcohol, agar, hydrophobic polymers like ethyl cellulose, eudragit S100 and dichloromethane as crosslinking agent. Prototypes A3, D1 and E were selected based upon the yield Further screening was done based on morphology (SEM images), particle size (8.829μm, 0.567μm, 17.416μm resp.) and entrapment efficiency (49.01%, 81.75%, 34.71%) and Prototype E1 was selected for optimization. Optimization was done by using 32 factorial design with design expert software and formulations F1 to F9 were developed. Using entrapment efficiency as the response, contour plot and surface response curve were plotted. GC analysis of dried sample of nanosponge formulation reflected all major constituents present in the oil concluding that the constituents of the oil were unaffected by the formulation process. Optimized nanosponges were incorporated in hydrogels and tested for viscosity (67,666 Centipoise), spreadability...
Read More
Posted by admin on May 31, 2026 in |
Glipizide, a second-generation sulfonylurea, is extensively employed in the management of Type 2 diabetes mellitus due to its insulin secretagogue activity. However, its limited aqueous solubility, as classified under the Biopharmaceutics Classification System (BCS) Class II, results in dissolution rate-limited absorption and suboptimal oral bioavailability. The present investigation was aimed at enhancing the solubility and dissolution profile of Glipizide through the formulation of solid dispersions, followed by the development of fast-disintegrating tablets (FDTs) to improve therapeutic efficacy and patient compliance. Solid dispersions of Glipizide were prepared using sodium caprylate as a hydrophilic carrier in varying drug-to-carrier ratios (1:1 to 1:5) employing the solvent evaporation technique. The optimized ratio (1:3) was selected based on preliminary solubility enhancement studies. Fast-disintegrating tablets were subsequently formulated by direct compression utilizing superdisintegrants such as croscarmellose sodium, sodium starch glycolate, and locust bean gum at different concentrations. The prepared formulations were evaluated for micromeritic properties, tablet hardness, friability, content uniformity, disintegration time, and in vitro dissolution behavior. The results demonstrated that all formulations exhibited acceptable...
Read More
Posted by admin on May 31, 2026 in |
Ambrisentan is an endothelin receptor antagonist for rapid administration during early disease progression to provide therapeutic benefit. This study aimed to develop Ambrisentan as a fast-dissolving oral film (FDOF) and evaluate the physicochemical and performance characteristics of the formulated films. The FDOFs were prepared using film-forming polymers, including hydroxypropyl methylcellulose (HPMC E6 LV) and 2-hydroxypropyl β-cyclodextrin (HPβCD), with xanthan gum and propylene glycol 400 at varying concentrations. Eleven formulations were developed and evaluated for parameters including film color, thickness, brittleness, peelability, transparency, surface smoothness, tackiness, film-forming capacity, content uniformity, dispersion time, and dissolution behaviour. The optimized formulation (F9) showed excellent film properties, with content uniformity of 99.6 ± 0.8%, dispersion time of 15 ± 2 s, and dissolution rate of 98.2 ± 1.08% within 12 min. Fourier transform infrared spectroscopy revealed no physicochemical interaction between Ambrisentan and polymers. Differential scanning calorimetry showed no significant changes in the melting endotherm of the pure drug and optimized formulation, indicating drug-excipient compatibility. Comparative dissolution studies demonstrated that formulation F9 exhibited superior dissolution...
Read More
