Posted by admin on Nov 30, 2022 in |
The current research is an attempt to investigate the antibacterial and synergistic bioefficacy of Curcuma caesia (Roxb.) versus human pathogenic bacteria viz., Bacillus cereus, Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa and Proteus vulgaris procured from IMTECH, Chandigarh, India. Agar well diffusion assay was performed, and one-way ANOVA examined the outcome. The qualitative phytochemical examination revealed a positive test for flavonoids, glycosides, phytosterols, resins, saponins, and tannins. However, the quantitative estimation of phytochemicals revealed that the root sample contains highest amount of flavonoid followed by total phenol, saponin and alkaloid. The bioactive extract was purified using column chromatography. The purified fraction and commercially available antibacterials viz., tetracycline, streptomycin, and penicillin was evaluated for their synergistic or antagonistic efficacy counter to multi-drug resistant human pathogenic bacteria. The outcome divulge that a purified fraction of C. caesia was found to act synergistically with tetracycline against all the bacterial cultures under investigation. The results with streptomycin showed maximum synergistic activity against B. cereus. However, penicillin and purified...
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Posted by admin on Nov 30, 2022 in |
Background: In the present investigation Antineoplastic loaded transdermal patch was formulated using Liposomes, eudragit-RL, hydroxypropyl methyl cellulose K-50, and ethyl cellulose. Materials and Methods: Liposomes were formulated by solvent evaporation method using poly (sebacic acid-co-ricinoleic acid) in varying ratios and evaluated for particle size, drug loading, entrapment efficiency, transmission electron microscopy, differential scanning calorimetry and X-ray diffraction. Formulated tamoxifen-loaded liposomes were finally incorporated into transdermal patch and evaluated for thickness drug content, moisture content, moisture uptake, folding endurance, tensile strength diffusion coefficient, permeability coefficient, in-vitro permeation, and skin irritation. Optimized transdermal patches were tested for its pharmacokinetic and pharmacodynamics parameters. Results: Formulated transdermal patches showed improved bioavailability of tamoxifen when compared to its oral route. Conclusion: Tamoxifen-loaded liposomal transdermal patches could serve as a better alternative to existing marketed formulation in terms of...
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Posted by admin on Nov 30, 2022 in |
Background: Depression is a state of mental illness characterized by long-lasting moods of desolation. Typical to atypical antidepressants are available in modern medicine for depression therapy, but the side effects are still questionable. Aqueous extract of Abelmoschus esculentus seeds (AEAES) from the Okra has been chosen for the study. AEAES has already been shown to exhibit an antidepressant-like effect, but there is no information about its mechanism. The current study has studied the monoaminergic and opioid systems’ involvement in the antidepressant effect of AEAES. Methods: The current study has shown the signal for the role of nor-adrenergic and serotonergic systems in the antidepressant activity of AEAES in mice using the Forced swim test (FST). Swiss Albino female mice were treated with vehicle AEAES (200 mg/kg) orally, and different types of receptor antagonists were used to demonstrate the mechanism of action of an AEAES. Results: The antidepressant action exhibited by AEAES was obliterated by the pre-treatment of mice with p-chlorophenylalanine (100 mg/kg, i.p., serotonin synthesis inhibitor), Ketanserin (5 mg/kg, i.p.,...
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Posted by admin on Nov 30, 2022 in |
Introduction: Proximal tibia is a weight-bearing area, and treating these fractures is challenging. Various treatment options will be closed reduction and casting, Open reduction and internal fixation with plate osteosynthesis, and minimally invasive plate osteosynthesis (MIPO). The advantage of MIPO in this type of fracture is that it requires only minimal exposure for stable fixation and will give a better quality of life with less complications. The study aimed to assess the functional outcome of MIPO in treating the proximal tibia fractures. Materials and Methods: A prospective study of 30 patients was conducted in patients treated with the MIPO technique for closed proximal tibia fracture. Sanders score was assessed for functional outcome in 6th month. Results: The mean age of the patients was 43.16 years. Lateral column MIPO alone was done in 22 patients and Dual column MIPO was done in 8 patients. The mean time to union of fracture was 12.16 weeks ranging from 11 to 18 weeks. Sanders score at 6th month showed excellent results in 18...
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Posted by admin on Nov 30, 2022 in |
Introduction: Osteoarthritis Knee (OA) is the most common form of joint disability in elderly individuals. Various treatment modalities have been established for OA. This study is to compare the functional outcome and pain relief following IA (intraarticular) steroid versus PRP (platelet-rich plasma) injection. Methods: In this study 30, patients were selected and segregated into two groups 15 each with knee pain for more than 1 year. Each patient would either be treated with IA steroid injection or PRP injection. Patients immediate post-injection VAS and HSS scoring were recorded. Result: Group A and Group B were treated with IA steroid and PRP respectively. BMI (body mass index) was found to be of great significance. Patients were reassessed after injection at 1-month intervals of 1, 2, and 3 months. Visual Assessment Scoring also was used pre-injection. Post injection reduction in pain was recorded with a reduced score in 1month and 2month post-injection follow-up. In this comparative study, patients with PRP injection had better pain improvement over a long period with excellent...
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