Posted by admin on Mar 31, 2022 in |
A chronic illness that affects a person’s mood, thoughts, physical health, and behavior patterns is considered depression. Currently used anti-depressant drugs such as selective serotonin reuptake inhibitors (SSRI) and tricyclic anti-depressants (TCA) are showing various side effects and thus, the search for a new anti-depressant herb without side effects is important. The intend of the present study was to evaluate the anti-depressant effect of methanol, chloroform and aqueous extract Acacia nilotica leaves at doses of 200 mg/kg in experimental animals. In-vivo screening models like Forced Swim Test (FST), Tail Suspension Test (TST) and Spontaneous Locomotor activity (SLMA) were used to assess the anti-depressant effects of the methanol, chloroform, and aqueous extracts of Acacia nilotica Linn. The dried-up leaves were subjected for shade drying and size reduced to powder and extracted by soxhlet apparatus. The extracts were subjected to phytochemical tests and the carbohydrate, tannins, alkaloids, flavonoids, saponins, glycosides and steroids were found to be present. Imipramine (30 mg/kg, i.p) was used as the reference standard, and it showed significant...
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Posted by admin on Mar 31, 2022 in |
The present study focused on the formulation and in-vitro evaluation of 0.05% 5-fluorouracil solid lipid nanoparticle gel in treating actinic keratosis. The in-vitro release profile of solid lipid nanoparticle gel is higher than the marketed cream formulation; thus, we can reduce the dose of formulation by this method. This is prepared using tween 80, tween 20, glycerol monostearate, glycerol, and lecithin. Pre-formulation studies for the pure drug were conducted, and formulations were evaluated based on viscosity, encapsulation efficiency and in-vitro drug release study using franz diffusion cell. FTIR study of pure drug-polymer and formulation proves there is no chemical interaction between them. Formulation SLN2 had appropriate viscosity of 1738.34, the highest encapsulation efficiency of 94.45%, drug loading 31.97%. SLN2 shows 95% cell viability. The in-vitro release study was found to have a zero-order release profile. Compared to all other formulations, this indicates the predominant mechanism of drug release is...
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Posted by admin on Mar 31, 2022 in |
Introduction: Most human oro-facial infections originate from odontogenic infections, and prescribing antimicrobial has become a ubiquitous phenomenon. The World Health Organization (WHO) has recognized the inappropriate, indiscriminate and irrational use of antimicrobials leading to antimicrobial resistance. Aim & Objective: To assess the knowledge of antimicrobial resistance and antimicrobial prescription among dental practitioners in Chennai city. Materials and Methods: A total of 110 registered dental practitioners participated in this cross-sectional study. A pre-validated and self-administered questionnaire was prepared and distributed to the registered dental practitioners in Chennai city to collect the demographic details and the information regarding knowledge and practice towards antimicrobial resistance and an antimicrobial prescription for the most common oral conditions and commonly prescribed antimicrobials for their patients were obtained. Statistical analysis. The data were statistically analyzed by using the Statistical Package for the Social Science version 20.0. Descriptive statistics were performed, and a Chi-square test was done to assess the association between knowledge and practice of BDS and MDS participants. Results: 79.66% of BDS and 92.16% of...
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Posted by admin on Mar 31, 2022 in |
Pullulanase (Pullulanase-α-glucanohydrolase EC 3.2.1.41) is a glucanohydrolase enzyme that can break down the pullulan and allied oligosaccharides into glucose. Promising of starch-based industries are biofuels, starch syrup, nutraceuticals, etc., increase the glucanohydrolases demand. Present investigation revealing that the Bacillus cereus KKSJ 1981 is enhanced the production of pullulanase through the optimization of temperature, agitation speed, pH, soluble starch concentration, MnSO4 and yeast extract. Response surface methodology (RSM) was utilized to optimize the selected six parameters. A central composite design with 50 experiments was performed in this investigation. The analyzed data depicts that the correlation coefficient (R2) value was 0.9873, and the adjusted R2 value was 0.9717 indicates the high significance of the model. Further, the selected parameters in optimum conditions were predicted through the developed mathematical model, and validation experiments were performed at these conditions. Overall, 1.2 folds of pullulanase were improved through the RSM based...
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Posted by admin on Mar 31, 2022 in |
The research work is focused on the formulation of dermal drug delivery system of Fisetin. The formulation based on the principal to causes deeper skin penetration and minimal systemic delivery for the management of skin cancer by enhancing the dermal bioavailability of formulation with reducing dosage requirement in sustained delivery mode by direct targeting of formulations to the skin. Two formulations viz transethosome and ethsosme were formulated to attain the efficient dermal delivery of fisetin. The surface morphology was studied by using Zeta sizer procedures. The formulation had shown adequate strength, consistency, cohesiveness, and list of thickness as 330.50 g, 314.69 g, 2.34.50 g, and 112.71 g separately. The streamlined fisetin transethosome gel definition detailing had 90% spreadability and a pH of 6.5 ± 0.2. These properties guarantee uniform spreading of OFTF-gel at the application site without causing skin irritancy. OFTF-gel had shown great substance consistency with 99.5 ±1.5 % of medication recuperation from the gel by HPLC assessment. The skin treated with transethosomes gel had shown altogether higher...
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