Posted by admin on Oct 31, 2022 in |
Single Cell Protein (SCP) refers to the dead, dried cells of various microbes, including bacteria, yeast, algae, and fungi. This type of biomass can be obtained from economically cheap substrates like agro-wastes as a non-conventional proteintious source for human or animal feed. The bioconversion of Darjeeling mandarin peels into single-cell protein (SCP) was performed using Aspergillus niger and Aspergillus oryzae, by submerged fermentation. The study revealed that supplementing Darjeeling mandarin peels with inorganic nitrogen and glucose as carbon sources improved the fungal biomass and single-cell protein production. Aspergillus niger showed the highest biomass and protein yield of 2.53±0.005gm/l and 1.25 gm/l or 43.57±0.00%, respectively. The present study revealed that fungal biomasses had shown crude fat (ranging from to1.16gm/l), crude fiber (ranging from 0.06±0.001to1.97 gm/l), and total genomic DNA content (from 1.85±0.001-2.20±0.001%). Maximum ash content was observed by A. niger biomass in GMPM (3.89%). A. niger converted sugar 71.4% to yield biomass. A. niger and A. oryzae were useful for producing fungal biomass from Darjeeling mandarin...
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Posted by admin on Oct 31, 2022 in |
Chronic diseases such as cardiovascular, cancer, and respiratory diseases are being increased. Reactive oxygen species, free radicals, and oxidative stress play a major role in aggravating these diseases. Plants and plant-derived compounds have shown a greater potential in combating the detrimental effects of free radicals and other toxic agents. The current research work has been done on the leaf and bark of Saraca asoca to evaluate its free radical scavenging antioxidant properties. The antioxidant activities of Saraca asoca methanolic extract were assessed by employing ABTS Radical Scavenging Capacity, DPPH, Superoxide Radical, Hydroxyl Radical, Lipid Peroxidation, and Nitric Oxide Scavenging Ability. The leaf and bark extract results assessed against ARSC, DPPH, Superoxide, Hydroxyl, Lipid Peroxidation, Nitric Oxide, FRAP exhibited remarkable IC50 values in a concentration-dependent manner, thus proving it as a potential antioxidant. The results of the present comprehensive analysis demonstrated that Saraca asoca leaf and bark extract exhibited excellent antioxidant activities and could be exploited for further nutraceutical and medicinal applications effective in treating many...
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Posted by admin on Oct 31, 2022 in |
Most of the medications currently in use are largely derived from the traditional plants and their products. Lawsonia alba, often known as henna, has a wide range of medicinal uses, from minor infections to cancer and is also used as a hair dye. All of these pharmacological actions and therapeutic uses are because of the presence of numerous secondary metabolites. These were isolated using the GC-MS technique from the aqueous extract of L. alba leaves. The compounds were then analyzed for pharmacokinetics and pharmacodynamics by using SwissADME, OPENBABEL, Swiss target prediction, etc., like software. In the aqueous extract of L. alba, we obtained 91 compounds; out of these 38 were significant, but only 09 compounds were in prominent concentration, and all of these 09 compounds were non-toxic, they are orally absorbable molecules with acceptable lipophilic and hydrophilic nature which were subjected to various software to obtain the target protein that can dock with specific properties of modulating various proteins/receptors/enzymes and these compounds or their derivatives can be considered as...
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Posted by admin on Oct 31, 2022 in |
The main objective of this research work was to formulate and evaluate an Orodispersible tablet of Bisoprolol Fumarate for the treatment of hypertension and coronary artery disease. Formulation was designed using systat software version 13.2. 32 full factorial design was applied, in which two variables were varied at three levels. The tablets of Bisoprolol Fumarate were developed by direct compression method. The prepared tablets were evaluated for thickness, hardness, friability, weight variation, wetting time, content uniformity, disintegration time and in-vitro dissolution. FTIR studies indicated that drug and excipients were compatible. Pre-compression and post-compression parameters were satisfactorily within acceptable limits. The results indicated that concentration of croscarmellose sodium and diluents ratio significantly affected on disintegration and in-vitro dissolution study. Formulation SF9 showed shortest disintegration time (7.3 sec.), shortest wetting time (13.4 sec) and better drug release (99.8%) compared to other formulations. Hence it was selected as optimized formulation. The 3D response surface plots indicated that an increase in the concentration of croscarmellose sodium and an increase in the diluent ratio decreased...
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Posted by admin on Oct 31, 2022 in |
Presently, in-silico approaches have been introduced as alternative methods for the process of drug invention. The current investigation aimed to explore expectations and the examination of the chemotherapeutic potential dietary phytochemicals as effective anti-cancer agents against HER2. This receptor plays a pivotal role in the development of breast cancer. Here, protein-ligand virtual screening was established as a coherent strategy for the identification of new inhibitors. The primary screening was performed with a molecular approach using iGEM DOCKv2.1 software. Bioinformatics & system analytical techniques were used for the extrapolation of adverse assessments. Lastly, the best compounds with a good outfit score, non-toxic and better drug-likeness esteems were scrutinized for interactions with the key residues and were escalated to final screening. The final re-docking simulation was performed using AD Vina in pyrx 0.8 software. Finally, the top Phytoconstituents as the best binders to the active site of protein structures and muscularly agree with massive experimental consequences. The results confirmed that (2R, 3R)-2-(3, 4-dihydroxyphenyl)-3, 4-dihydro-2H-chromene-3, 5, 7-triol and 2-(3, 4-dihydroxyphenyl)-3, 7-dihydroxychromen-4-one can...
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