Posted by admin on Aug 31, 2022 in |
Inflammation is considered a primary physiologic defense mechanism that helps the body to protect itself against infection, burn, toxic chemicals, allergens, or other noxious stimuli. Inflammatory diseases are currently treated with steroidal and non-steroidal anti-inflammatory drugs (NSAIDs). Unfortunately, both of these widely prescribed drug classes have significant negative side effects. Hence, there is a need to develop new drugs with novel modes of action that do not produce considerable side effects. The use of traditional medicine and medicinal plants in most developing countries as a normative basis for the maintenance of good health, has been widely observed. So, crude flavonoid fraction of Mitragyna parvifolia was screened for anti-inflammatory activity using Carrageenan induced method and Formalin induced method at various doses (50,100 &200 mg/kg), and the results were compared with standard drug diclofenac sodium (20 mg/kg). It showed significant activity at 200 mg/kg. The Crude flavonoid fraction was also screened for antioxidant activity at various concentrations (20, 40, 60, 80,100μg/ml) using the DPPH free radical scavenging method. The antioxidant activity...
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Posted by admin on Aug 31, 2022 in |
Lassa fever is a serious viral haemorrhagic illness caused by Lassa virus, a family of Arenaviridae. This haemorrhagic fever has become rampant in West Africa especially in Sierra Leone, the Republic of Guinea, Liberia and Nigeria, through exposure to food or household items contaminated with urine or faeces of infected Mastomys rats. There has been no vaccines or particular antiviral agents/drugs against the treatment of Lassa fever, but some drugs such ribavirin, lacidipine, phenothrin and remdesvir are being used in the early stage of the illness. The goal of the present work was to use in-silico methods via molecular docking and ADMET properties to assess the effectiveness of these drugs alongside the botanical drugs (Bergamottin and Casticin) found in grapefruits and Artemisia annua. The results showed that Remdesvir possesses outstanding inhibitory action against nucleoprotein (NP) of the Lassa virus, although Phenothrin and Casticin were active against 3MWP, Lacidipine and Casticin were active against 3MWT, 3MX5 and 3T5Q and Bergamottin, and Casticin were against 3T5N and 4FVU; Thus Remdesvir and...
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Posted by admin on Aug 31, 2022 in |
December 2019 has become one of the most surprising days in the whole world in light of the flare-up of a most infectious sickness brought about by novel Covid or Severe Acute Respiratory Syndrome Corona virus 2 (SARS-CoV-2). This study is conducted to assess the benefits of the use of home remedies to prevent the cause of Covid-19 and evaluate the assessment of dietary changes and physical activity in the prevention of Covid-19. A questionnaire-based online survey is conducted using Google forms consisting of multiple-choice questions about home remedies, lifestyle and dietary changes made by the people during this pandemic. These home remedies included using different types of herbal preparations, steam inhalation, physical exercise and OTC medications for prophylaxis. Questions likewise included about being infected by Coronavirus-19(during first wave or second) and their recovery period, additionally collected their viewpoint for changes made, for example how much they are useful in the prevention of the attack and whenever encountered any undesirable impacts. Total responses were 210, among which 121(57.6%) responses...
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Posted by admin on Aug 31, 2022 in |
The purpose of the current research was to formulate and evaluate patient-friendly allopurinol solid dispersion based fast-dissolving tablets using a sublimation technique in order to accomplish rapid drug dissolution. In the present study, an effort was made to fasten the release of allopurinol from oral tablet dosage form by the conversion of the drug into solid dispersion form followed by further incorporation of allopurinol solid dispersions with superdisintegrants and camphor/ammonium bicarbonate as the subliming agents. The prepared fast-dissolving tablets of allopurinol solid dispersion were analyzed for pre-compression and post-compression parameters. Based on the results obtained for in-vitro drug release studies, it was observed that the formulation F8 showed a fast release profile of about 99.51% in 30 min and a disintegration time 40 sec in comparison with other formulations. The initial dissolution rate was 34.25% / 10 min for the best formulation, F8. FT-IR studies disclosed that there were no interactions between drugs and excipients. The current investigation revealed the potential for the rapid dissolution of allopurinol solid dispersion...
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Posted by admin on Aug 31, 2022 in |
The aim of the research work was to determine and compare the efficacy and pharmacoeconomics of Atorvastatin and Rosuvastatin. The cohort, observational, and prospective studies were conducted at KMC multispeciality hospital, Trichy. The hyperlipidemic patient was treated with Atorvastain (10 mg) and Rosuvastatin (5 mg) every day over a period of six months. Contemplating the inclusion and exclusion criteria, 104 patients were selected for the study. From the selected 104 patients, 52 patients were treated with Atorvastatin (Group- A) and Rosuvastatin (Group- B). The therapeutic effect of both drugs was compared. The level of Total cholesterol (TC), Triglyceride (TG), Low-density lipoprotein (LDL), and High-density lipoprotein (HDL) were estimated. Rosuvastatin-treated patient’s reports showed a significant reduction in total cholesterol, triglyceride, and low-density lipid-protein, and increased the high-density lipoprotein during the therapy compared to Atorvastatin treated patient’s group. The results revealed that Rosuvastatin is more effective than Atorvastatin and Rosuvastain is cost effective than...
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