Posted by admin on Aug 31, 2022 in |
The present study aimed to determine the antioxidant potential of different solvent extracts of A. malabarica. Drug discovery from traditional medicinal herbs has played a significant role in the therapeutic management of cancer and, undoubtedly, most novel clinical applications of medicinal plants and its secondary metabolites and derivatives. The leaves extract showed various folklore and traditional applications in India. The polar and non-polar solvents extracts such as hexane chloroform, ethyl acetate, methanol, and aqueous were subjected to various in-vitro antioxidant assays such as DPPH, ABTS, Superoxide, Nitric oxide, Hydroxyl radical and Ferrous ion chelation, Butylated Hydroxy Toluene was used as a standard. The percentage of scavenging and chelation values for antioxidant were obtained and tabulated. Effective concentration (EC50) values are calculated using linear interpolation. The result clearly exhibited that the methanol leaves extract possesses more efficient antioxidant properties than the other extracts. This scavenging free radical capacity can be used as a good anti-oxidizing agent in various fields of medicine, the food industry...
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Posted by admin on Aug 31, 2022 in |
Breast cancer continues to pose a serious hazard to women worldwide. (EGFR) was one of the first key targets for these new anticancer drugs to be discovered. Triple-negative breast cancer affects almost half of all women in the World. This study focused on the phytochemicals from a medicinal plant Clitoria ternatea; these medicinal plants possess more phytochemical compounds that effectively fight against cancer cells. The five compounds were selected and a molecular docking study was performed against EGFR protein. The Pharmacokinetics and ADMET properties of these ligands help identify the best hits. Myricetin exhibits the highest binding energy among these five ligand molecules and is the best ligand to inhibit EGFR protein. Hence, this compound may act as a promising agent for treating breast cancer. However, more in-vivo and in-vitro testing is needed to establish their safety and efficacy in this...
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Posted by admin on Aug 31, 2022 in |
Background: Acute viral hepatitis (AVH) is a major public health problem. There is no specific treatment to attenuate AVH. The potential for adding bile acid in the treatment of AVH is consistently increasing. The objective of this study was to assess the effect of obeticholic acid (OCA) in treating AVH patients and also to compare its efficacy with ursodeoxycholic acid (UDCA). Methods: A prospective comparative observational study carried out at the Department of Gastroenterology of tertiary care hospital. A total of 38 patients were allowed to participate in the study and randomized into two study groups, Group I and II. Each group consists of 19 patients. Patients in group I treated with UDCA. Group II patients treated with OCA. Results: The most common symptoms observed in the two study groups were nausea /vomiting followed by loss of appetite and abdominal pain. Both Group I and II patients showed significant improvement in their symptoms after treatment. The mean of liver function test (LFT) parameters was compared before and after treatment....
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Posted by admin on Jul 31, 2022 in |
Mosquitoes are carriers of the DENV and ZIKV diseases. DENV and ZIKV are epitopes. The current performance and technique of some of the most frequently used B-cell epitope predictors used for DV and ZV proteomes are reviewed in this paper. Our specific prediction methods, ABC pred, BC pred, and AAP Methods, as well as FBC pred, were utilized to predict 1529 B cell epitopes. For the B cell epitops, the stability index, aliphatic index, GRAVY, antigen city, allergen city, toxicity, clustering, and conservancy were investigated further. The anticipated immunogenic epitopes PLPWHAGADTGTPHWNNKEA, GGFGSLGLDCEPRTGLDFSD of ZIKV and IGVEPGQLKLSWFKKGSSIG, VEPGQLKLSWFKKGSSIGQM, IEAKLTNTTTASRCPTQGEP, LPLPWLPGADTQGSNW of DENV were 100 percent conserved. The goal of this study is Flaviviridae viruses that now affect 128 nations throughout the world. And they may both be fatal and life-threatening. A quicker and less expensive vaccine design procedure used to identify the B cell was to use computer simulations to find potential vaccination candidates and antiviral efficacy testing. The study’s goal is to develop patient therapies that are both safe...
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Posted by admin on Jul 31, 2022 in |
Background: Colorectal cancer is the fifth most common cancer and the leading cause of cancer-related deaths in India. The incidence, mortality, and prevalence rates are consistently higher. Precautionary measures in preventing colorectal cancer still remain a challenging issue. Aims and Objectives: This study was undertaken to correlate the specificity, sensitivity & efficiency of TIMP-1 and MIF protein that are non-invasive and enable us to detect CRC quite early. Analysis of CEA, Ca19-9, Fecal Hemoglobin were done as diagnostic markers & TIMP-1, MIF protein, CRP, prolactin as prognostic and molecular markers. Total 120 patients were included in the study and categorized as stage I-IV with recurrences and without recurrences which were compared with healthy controls. Results: The study observed increased CEA, CA19-9, fecal Hb in various stages of colorectal cancer as compared to control. Prolactin, CRP, TIMP-1, MIF Protein show significant (p<0.001) rise in various stages. The elevated levels are increased concomitantly from stage 0 to IV suggesting the severity and distance spread of the disease. CEA, CA19-9, and fecal...
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