Posted by admin on May 31, 2022 in |
This study was designed to evaluate and compare the Antidepressant effect of Ibandronate with Amitriptyline on depression models in albino mice. Eighteen Swiss albino mice weighing 20-25 grams were selected and divided into three groups of six animals each. Group 1: Normal Saline- 0.5 ml, Group 2: Amitriptyline – 39 mg/kg, Group 3: Ibandronate 0.325 mg/kg administered orally every day for 30 days. Animals were subjected to a forced swim test, tail suspension test, and Locomotor activity test on 1st, 10th, 20th and 30th day of the experiment after 1 hour of drug administration. The forced swimming test and Tail suspension test detected the duration of immobility, whereas the Actophotometer test detected the influence of the drug on the Locomotor system. The data reveal that Ibandronate has an antidepressant action that did not differ significantly from Amitriptyline. Ibandronate a Bisphosphonate has shown an antidepressant effect on depression models in albino...
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Posted by admin on May 31, 2022 in |
Ulcerative colitis was defined as a common intestinal infla-mmatory disease characterized by upregulation of pro-inflammatory cytokines and oxidative stress. The leaves of Murraya koenigii and Centella asiatica had been used in traditional medicine to treat the disease. The present study aimed to perform a comparative protective efficacy evaluation between Murraya koenigii and Centella asiatica on acetic acid-induced ulcerative colitis in rats. Rats were randomly categorized into nine groups: control, acetic acid, standard drug, acetic acid + extract of Murraya koenigii (50, 100, 200 mg/kg), and acetic acid + extract of Centella asiatica (50, 100, 200 mg/kg) groups. After 5 days of feeding, colitis was induced in the experimental animal groups by transrectal administration of 1ml of 4% acetic acid. The rats were sacrificed after 24 hr of rectal installation, and their colon tissues were examined. Pretreatment with extract of Murraya koenigii and Centella asiatica significantly reduced colon weight-length, macroscopic scores, histological changes, and upregulated the enzymatic activity of superoxide dismutase (SOD). The above results indicated that oral administration of...
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Posted by admin on May 31, 2022 in |
Acute Lung Injury (ALI) and its more severe form Acute Respiratory Distress Syndrome (ARDS) is a clinical syndrome with a high mortality rate (27-41%). There is no pharmacological therapy for ALI treatment so far because of the complex mechanism and involvement of multiple pathways. So, the present study was designed to test the role of different extract/fractions of fruits of a traditional plant Randia dumetorum Lamk. utilizing a mouse model of acid aspiration (HCl) mediated ALI. Hydromethanolic extract (HME) was screened for anti-inflammatory activity at 100, 200, and 400mg/kg doses employing total and differential cell count in bronchoalveolar lavage fluid. Our data demonstrated that oral administration of HME in mice before induction of ALI resulted in reducing the number of BALF inflammatory cells, particularly neutrophils, in a dose-dependent manner. Further, HME was partitioned into ethyl acetate soluble (EASF) and ethyl acetate insoluble fraction (EAISF) to extract phytoconstituents based on differential polarity. Our data revealed that EAISF showed better efficacy than EASF for the amelioration of lung inflammation. Similarly, bioactive...
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Posted by admin on May 31, 2022 in |
Background: To date, the 2019 novel coronavirus pneumonia (COVID-19) is the greatest public medical issue in the world. World Health Organization (WHO) declared this outbreak a “public health emergency of international concern” on January 31, 2020. Therefore, it bodes well to look for a potential biomarker that could quickly and effectively distinguish serious cases early. Of the total confirmed Covid-19 patients, the severe cases often suffer from underlying diseases such as cardiovascular disease and diabetes that can accelerate the movement of 2019 novel coronavirus (SARS-CoV-2) infection. Moreover, acute respiratory distress syndrome could lead to death in some severe Covid-19 patients, and various disorders often accompany this. Biochemical findings showed representative features of acute respiratory distress syndrome and association of multiple organs. Aim: To estimate routine biochemical parameters of patients admitted to the Covid-19 ward. Method: Clinical samples from cases of Covid-19 admitted to Adesh Medical College and Hospital, Mohri, Shahbad (M), Haryana, India, during 1st, 2nd, and 3rd waves were collected and analyzed. Result: In this study, we investigated...
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Posted by admin on May 31, 2022 in |
Hedychium spicatum is one of the plant species reported from the northern Himalayan ranges of India, belonging to the family Zingiberaceae, with ethnobotanical values and is well-known for their ethnomedicinal applications. In the present investigation, pet ether and ethanolic rhizome extracts of Hedychium spicatum were Analyzed by gas chromatography-mass spectrometry (GC–MS) to identify the important phytochemical constituents. The GC–MS analysis of pet ether and ethanolic extracts from rhizomes of Hedychium spicatum detected the presence of numerous phytochemical compounds. Further, the literature review reported rhizome extracts of H. spicatum to have remarkable anti-inflammatory, antioxidant, cardioprotective, and antibacterial activities. The results of DPPH and ferric reducing antioxidant power assay recorded maximum antioxidant activity in Hedychium spicatum ethanolic rhizome extract at 500mg/kg dosage. As well as the ethanolic extract exhibited maximum α-amylase inhibition activity followed by exhibiting aldose reductase inhibition. Subsequently, the six identified compounds were analyzed for their bioactivity through in-silico molecular docking studies. Results revealed that 7-hydroxyhedychenone might have maximum antioxidant and antidiabetic properties among the phytochemical compounds identified, followed...
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