Posted by admin on Mar 31, 2022 in |
The adverse environmental impact of fungicides used in plant disease control is escalating day by day. Generally, plant diseases are controlled by synthetic fungicides, chemical methods, and bio-control agents. Chemical methods lead to deterioration of soil fertility and cause pollution. Being highly stable and resistant to biodegradation, chemical fungicides also enter the food chain and are responsible for many harmful effects on human health and the environment. Hence, eco-friendly alternative methods are of great urgency. One of the prominent approaches in this direction includes utilizing plant extracts with natural antifungal constituents. So, a study was attempted to determine the antifungal and phytochemical activity of underexploited leafy vegetables. Methanol and water extracts of the leaves were tested against two economically important plant pathogens Alternaria solani and Pythium aphanidermatum and the antifungal activity of plant extracts was determined. All the plant species under study showed inhibitory activity against the plant pathogens. However, B. diffusa and C. frutescens exhibited maximized efficiencies. Moreover, the water extracts of B. diffusa and C. frutescens (1%)...
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Posted by admin on Mar 31, 2022 in |
The present investigation screening and characterization of α-amylase and antimicrobial compound producing filamentous fungi is used for extensive commercial applications in various sectors and is highly demanded in the Biotech industry. The results reveal that out of the carbon substrates alone, sugarcane bagasse with a combination of Tween-80 was found to yield maximum α-amylase (151.76 IU) under solid-state fermentation by different species of fungal species such as KRV_001Chaetomium oryzae, KRV_002 Penicillium citrinum, KRV_003 Aspergillus flavus, KRV_004 Penicillium notatum, KRV_005 Alternaria longipes and KRV_006 Trichoderma polysporum. Among them, KRV_001 Chaetomium oryzae, KRV_002 Penicillium citrinum, KRV_005 Alternaria longipes were maximum expressed α-amylase based on the plate assay by different pH, temperature and different substrate using amylase activity, SDS-PAGE, Antimicrobial activity has been done in Methanol extract exhibited antibacterial activity against S. aureus MTCC96 whereas the water extract displayed antibacterial activity. The organism produces volatile and water-soluble antibiotics and shows significant inhibition as the potential value of KRV_001Chaetomium oryzae and little less activity of KRV_006 Trichoderma polysporum among the isolates was...
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Posted by admin on Mar 31, 2022 in |
Aim: The present investigation deals with the preliminary phytochemical screening, in vitro antioxidant, and in vivo antidepressant activity of ethanolic leaf extract of Manilkara zapota. Materials and Methods: In-vitro antioxidant activity was evaluated using AS free radical scavenging parameters using Hydroxyl radical scavenging assay, phosphor molybdenum antioxidant assay and NO scavenging activity, and H2O2 scavenging assay. The forced swim test, tail suspension test and locomotor activity using a digital Photoactometer were used to investigate the extract’s antidepressant activity further. AA, fluoxetine (10 mg/kg) and imipramine (4 mg/kg, p.o) were used as reference drugs for comparison. Results and Discussions: The presence of these bioactive constituents is linked to the plant’s antioxidant and antidepressant activity. The IC50 values of Hydrogen peroxide and Hydroxyl radical scavenging were found to be 24.5 and 81.28 ug/ml for extract and 7.94 and 40.7 ug/ml for AA. In our study, the extract showed a significant (P< 0.01) reduction in immobility in the tail suspension and forced swim models of depression, comparable to imipramine. Conclusion: psychostimulant effect...
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Posted by admin on Mar 31, 2022 in |
The Aim and objective of this work were to build up a gastro retentive drug delivery system. Cimetidine is used as a model drug for making mucoadhesive dosage forms. The formulation can be achieved by using the ionic gelation method. The model drug used in this work plan is categorized in antiulcer treatment. The extended-release mucoadhesive microspheres of the drug provide constant plasma concentration with a less frequent administration and also reduce the side effects to some extent. They provide good administration and enhance patient compliance. The present study aims to develop mucoadhesive microspheres of the model drug by using polymers like Sodium alginate and Carbopol 934 as an excellent mucoadhesive agent that can adhere to the gastrointestinal membrane for sustained drug delivery in the stomach. Calcium chloride was also used for making a solvent system. The preformulation study shows no interaction between drugs and excipients. The prepared microspheres of cimetidine particle size between 167.14-218.23μm. The entrapment efficiency of formulations was found to be 70.06-87.67%. In-vitro drug release after...
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Posted by admin on Mar 31, 2022 in |
Pain is the most common symptom of disease, which accompanies us from an early age. It is a safeguarding mechanism of the body from harmful stimuli. The definition of pain states that it is a subjective sensory and emotional experience. This study compared generic and brand drugs’ analgesics and anti-inflammatory activity using eddy’s hot plate method and plethysmometer models. Two studies were conducted by using oral and intraperitoneal routes of administration. In this study, generic drugs such as Ranbaxy, intagesic, and Diclovin. Branded drugs are such as Voveran, Dynapar, and Cipla are used. The analgesics activity and anti-inflammatory activity of generic and branded drugs are the same. So, it has been concluded that generic drugs also show same effect as branded...
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