Posted by admin on Jun 30, 2025 in |
Background: Allergic Fungal Rhinosinusitis (AFRS) is a common disease and denoted as Chronic Rhinosinusitis with polyps (CRSwNP). Presents as Eosinophilic nasal polyps, and allergic mucin in the nose and sinuses demonstrable with Functional Endoscopic sinus surgery (FESS) surgery. The biological markers predicting this disease entity are uncertain. Physicians experience difficult to predict the outcomes of various methods of treatment adopted to treat AFRS. Sometimes involvements of blood inflammatory cells were used to predict the recovery of the disease and its prognosis. Aim of the Study: To study the levels of pre-operative blood Eosinophils and Basophils in patients with AFRS and compare them postoperatively in terms of recurrence of polypi and allergic symptoms. Materials and Methods: 69 adult patients diagnosed with AFRS at the tertiary teaching Hospital in Andhra Pradesh were included. Patients were treated with FESS for AFRS. The final outcomes were assessed on the basis of blood Eosinophils and Basophils and correlating with the recurrence of symptoms and polypi. Results: Recurrence of polypi in 14 of 69 patients with overall...
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Posted by admin on Jun 30, 2025 in |
The study investigates the anti-implantation and early abortifacient effects of Luffa acutangula fruit, traditionally claimed by tribals in the Pandharkawada region of Maharashtra, on female albino rats. To evaluate its efficacy, fertile male and female albino rats were paired, and the females were divided into 13 groups, including a control group receiving distilled water and 12 experimental groups administered varying doses (100, 200, 400 mg/kg body weight) of L. acutangula extracts for 1-7 days. On the 10th day of gestation, laparotomy was performed to assess implantation sites and corpora lutea counts. Phytochemical analysis revealed the presence of several bioactive compounds, including alkaloids, flavonoids, and steroids, while no toxicity symptoms were observed in the treated animals. Results indicated significant post-coital antifertility activity, with a reduction in implantation rates ranging from 12.61% to 72% across different extracts. Notably, the chloroform and ethyl acetate extracts yielded higher litter sizes compared to the control group. However, other reproductive metrics, such as litter body weight, total body length, gestation period, and sex ratios, did...
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Posted by admin on Jun 30, 2025 in |
Background: Hepatic Encephalopathy (HE) is a condition that is generally seen in individuals suffering from liver cirrhosis. HE is described as a range of neuropsychiatric diseases in individuals with liver diseases. It is characterized by personality changes, intellectual impairment and a depressed consciousness. Toxic substances that are generally excluded from the body by the liver accumulate in the blood and ultimately reach the brain, causing HE. Incidence rate of HE is estimated by various authors at about 30-84% of cases with liver cirrhosis depending on the applied diagnostic methods and examined population. Ammonia is one of the major neurotoxins produced in HE. Various triggers of HE includes renal failure, GI bleeding, constipation, infection, alcohol consumption, etc. Typically, bacteria within the gastrointestinal tract generate ammonia, which is then processed and eliminated by the liver through metabolism. But in HE there is either a drop in the number of the performing hepatocytes, portosystemic shunting or both, resulting in dropped ammonia clearance and hyperammonaemia. Once ammonia crosses BBB, it has multiple neurotoxic...
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Posted by admin on Jun 30, 2025 in |
The objectives of the present study were to formulate facial powder cleansers using colored clays, green clay or red clay, as main ingredients and to investigate the foaming and cleansing properties of the powder cleansers. For foaming and cleansing purposes, natural foaming tea and synthetic sodium cocoyl isethionate (SCI), were employed. Eight formulations were prepared by varying types and amounts of colored clays (58.5% and 68.5% w/w) as well as surfactants (10% and 20% w/w). The formulations F1 to F4 contained red clay whereas F5 to F8 contained green clay. Then, appearances, pH values, foaming and cleansing abilities of the formulations were investigated. The stability of the cleansers was also evaluated by keeping the preparations at ambient temperature and 45 °C for 60 days. Small differences in color shades of facial cleansers were detected using a spectrophotometer and CIELAB color system. The prepared cleansers had weak acidic pH (pH 5.7 to pH 6.5). The formulations with synthetic SCI had superior foaming property to those with foaming tea (p <...
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Posted by admin on Jun 30, 2025 in |
Background: Tuberculosis is a great menace to mankind since ancient times. The genus mycobacterium was known to originate 150 million years ago. Despite the discovery of many newer methods in the diagnosis of tuberculosis, a robust point of care test is required for effective management of Paediatric tuberculosis. Methodology: We conducted this study in paediatrics department of N.M.C.H for 1 year. After obtaining written informed consent, we enrolled cases in our study. All cases were subjected for focussed history from Guardians. Gastric Aspirate, Sputum, Induced Sputum, Ascitic fluid, CSF were collected is a wide mouthed container for sputum microscopy & in Falcons tube for CBNAAT. The microscopic examination of the samples were done by LED microscope using Z-N staining Technique. Results: Out of 51 samples analysed by microscopy and CBNAAT, CBNAAT has higher positivity rate (17.6%) than microscopy technique (5.8%). Result analysed using chi square test, considering CBNAAT as gold standard. The resulting value (p=0.027) interprets that the p value is less than 0.05. It is statistically significant. Conclusion:...
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