Posted by admin on Apr 30, 2026 in |
The aim of present survey on herbal anti-hair fall shampoo emphasizing especially in Gangtok District of Sikkim and reveals a growing reliance on herbal hair care products in Sikkim. The methodology followed during the survey was a cross-sectional study, open ended semi-structured questionnaires, and survey data collection tools were employed; descriptive and inferential statistics were done. The finding reveled from the total nine medical stores within the Gangtok district of Sikkim and data collection include the availability, composition, usage patterns, and consumer preferences, brand name, company name, composition of the products, indication, stocks, packaging types, side effects, manufacturing date and expiring date of all the herbal anti-hair fall products. The popular brands like Himalaya 20%, Patanjali 19%, Biotique 10%, Lotus Herbals 13%, and Mamaearth 15% offer targeted benefits for reducing hair fall, strengthening roots, and promoting healthy hair growth and prominently dominant the Sikkim market. The highest usage was observed among females (60%), particularly those aged between30-40. The survey also revealed that consumers appreciated the natural origin, affordability, minimal...
Read More
Posted by admin on Apr 30, 2026 in |
The objective of the present study was to assess the in-vitro metabolic stability of oleanolic acid isolated from Lantana camara roots using liver microsomes from mouse, rat, and monkey, and to investigate interspecies differences in metabolic behaviour. Oleanolic acid was incubated with pooled liver microsomes in the presence of NADPH at 37 °C, and the depletion of the parent compound over time was quantified using an automated LC–MS/MS platform. Metabolic half-life (t½) and intrinsic clearance (CLint) were calculated based on the rate of disappearance of oleanolic acid during incubation. The results demonstrated clear species-dependent differences in metabolic stability. Oleanolic acid showed the longest half-life and lowest intrinsic clearance in monkey liver microsomes, indicating higher metabolic stability, followed by moderate stability in rat microsomes. In contrast, mouse liver microsomes exhibited a shorter half-life and higher intrinsic clearance, suggesting faster metabolic turnover. These findings reflect significant interspecies variability in microsomal metabolism of oleanolic acid. In conclusion, oleanolic acid exhibited moderate to good in-vitro metabolic stability, particularly in higher species, supporting its...
Read More
Posted by admin on Apr 30, 2026 in |
Background: Psoriasis is a chronic inflammatory skin disease affecting 0.8% to 2.8% of the Indian population. Understanding drug prescribing patterns is vital for enhancing rational drug use. Objectives: This study aims to analyse the prescribing patterns of drugs in psoriasis patients, using WHO core prescribing indicators and to characterize these patterns by demographic variables. Study Design: An observational, cross-sectional, retrospective study was conducted in the dermatology department of a tertiary care hospital over one year, following IEC approval. Data were analysed using MS Excel. Results: A total of 148 psoriasis patients were enrolled, with an average age of 40.06 years and a male-to-female ratio of 3.9:1. A total of 701 drugs were prescribed, averaging 4.73 drugs per prescription, with 71% being generic. Additionally, fixed-dose combinations (FDCs) accounted for 104 of the prescriptions. Plaque psoriasis was the predominant clinical type, noted in 75.67% of cases, with steroids being the most commonly prescribed drug group. Conclusion: The findings reveal significant deficiencies in the prescribing patterns for psoriasis treatment. Implementing educational interventions...
Read More
Posted by admin on Apr 30, 2026 in |
Background: Abnormal uterine bleeding (AUB) is one of the most common gynaecological complaints and a major indication for endometrial sampling. Histopathological evaluation remains the gold standard for identifying functional, organic, premalignant, and malignant lesions. Objective: To analyse the spectrum of histopathological patterns of endometrium in women presenting with AUB and to assess the association of age with significant endometrial pathology. Materials and Methods: This retrospective study included all endometrial biopsy and hysterectomy specimens received for AUB over a period of two years in a tertiary care hospital. Histopathological findings were categorized and correlated with age groups. Statistical analysis included chi-square test and binary logistic regression. Results: The most common finding was proliferative endometrium followed by pregnancy-related changes and secretory endometrium. Hyperplasia and carcinoma were predominantly seen in women above 40 years. Conclusion: Endometrial histopathology shows a strong age-dependent distribution. Increasing age is a significant predictor of organic and premalignant/malignant endometrial pathology, reinforcing the importance of routine histopathological evaluation in women with...
Read More
Posted by admin on Apr 30, 2026 in |
Urinary tract infections (Azhal Neerchurukku) are among the most common bacterial infections, causing significant discomfort and reduced daily functioning. This descriptive case series aimed to observe outcomes following the administration of the Siddha medicine Thirikandagathi Kiyaazham (TKK) in the management of Azhal Neerchurukku (UTI). Methods: Twenty participants diagnosed with Azhal Neerchurukku (UTI) were administered 50 ml of TKK twice daily for 10 days. Clinical symptoms (using the UTISA questionnaire), total WBC count, and urine culture results were assessed before and after the intervention. Results: Observational data indicated improvements in clinical symptom scores and urine culture findings in post-intervention. Notably, a transition to culture-negative status was observed in 50% of cases where Escherichia coli was initially isolated. Conclusion: In this case series, a 10-day course of TKK was associated with observed improvements in clinical and laboratory parameters among participants, particularly in E. coli-associated cases. These preliminary findings suggest that TKK may serve as a promising Siddha therapeutic option for managing Azhal Neerchurukku (UTI). Definitive conclusions regarding therapeutic efficacy require future...
Read More
