Posted by admin on Apr 30, 2026 in |
Plant mucilages are increasingly explored in pharmaceutical research as sustainable alternatives to synthetic excipients. Tinospora cordifolia (Guduchi), a well-known medicinal plant in Indian traditional medicinal system, as it possesses diverse therapeutic properties including immunomodulatory, antioxidant, and anti-inflammatory effects. The stem and leaves of Tinospora cordifolia have been widely studied, but the fruit pulp mucilage remains relatively underutilized despite its promising pharmaceutical potential. Mucilage, a polysaccharide-rich material, exhibits swelling, viscosity, and gel-forming characteristics that make it suitable for applications such as binding, disintegration, stabilization, and controlled drug release. Extraction of mucilage from Tinospora cordifolia fruit pulp provides a cost-effective and biocompatible excipient source, aligning with the growing demand for natural and eco-friendly materials in drug formulation. Preliminary evaluation of physicochemical properties, yield, and functional performance is essential to establish its suitability for pharmaceutical use. Furthermore, cytotoxicity and biocompatibility studies are critical to ensure safety before clinical application. Overall, the exploration of Tinospora cordifolia fruit pulp mucilage offers significant potential in advancing natural polymer-based drug delivery systems, bridging traditional medicinal knowledge...
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Posted by admin on Apr 30, 2026 in |
Aims and Objectives: To compare the effectiveness between cyclopentolate and tropicamide in evaluating refractive error among children between 6-16 years. Materials and Methods: This study was carried out in GVPIHC & MT in the department of ophthalmology. Sample of 90 children were taken. One eye (left) of the patient is dilated with cyclopentolate and simultaneously the other eye (right) with tropicamide. Cyclopentolate eye drops 0.5%, Tropicamide eye drops 1% are instilled into other eye for about 3 times for every 15min for about, and patient is asked to close eyes. Auto refractometer and subjective verification are done before and after administering cycloplegic drugs. Participants are evaluated on day 1 and 2 to evaluate post- cycloplegic effect. Results: The study predominantly consisted of children in age group of 9-11 years (34.44%) and 12-14 year (28.89%) age groups, where male there was predominance of 53.33% and 46.67% female, with major complaint of headache (46.67%). Hypermetropia was the most prevalent refractive error (40.00%). Tropicamide achieved maximum mydriasis than cyclopentolate (mean 25.6 vs....
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Posted by admin on Apr 30, 2026 in |
Rajapravartini Vati is an Ayurvedic formulation prescribed for gynaecological and menstrual disorders such as amenorrhea and is comprised of raw materials, namely Shuddha Kasisa (purified green vitriol), Hing (purified Ferula asafoetida), Tankana (purified borax) and Kumari (Aloe vera) mixed in equal proportions. The present work focuses on HPTLC-based evaluation and phytochemical profiling of commercially available Rajapravartini Vati samples. The work proposes a phytobioactive compound detected in the commercial samples as a marker compound for evaluation of Rajapravartini Vati. It also establishes it as a compound different from conventional expected marker compounds such as aloin from Aloe vera and ferulic acid from Ferula asafoetida, which were not detected in the commercial samples but only in the in-house laboratory raw material mixture. Aloin and ferulic acid were subsequently quantified in the prepared sample at concentrations of 0.99 mg/g and 0.92 mg/g respectively. The findings of the study thus provide valuable insights into the phytochemical fingerprint of Rajapravartini Vati and will help propel future work on the marker compounds studied...
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Posted by admin on Apr 30, 2026 in |
This study investigates the anti-Parkinsonian properties of ethanolic extracts derived from Physalis minima and Peronema canescens. Efficacy was assessed using a combination of in-vitro biochemical assays and in-vivo behavioural screening models in Swiss albino mice. Parkinson’s disease symptoms were induced and subsequently evaluated using the body swing test. Oral administration of the extracts, individually and in combination, noticeably reduced behavioural abnormalities associated with Parkinsonism. Treated groups exhibited significant increases in monoamine neurotransmitters, specifically dopamine (DA), compared to control groups (DA levels approximately 0.35 vs. 0.05). Furthermore, the extracts enhanced the endogenous antioxidant defence by elevating crucial biomarkers, including glutathione (GSH), glutathione peroxidase (GPX), catalase (CAT), and superoxide dismutase (SOD). These biochemical findings were complemented by histological investigations of brain tissue. The results indicate that both Physalis minima and Peronema canescens extracts possess considerable neuroprotective and anti-parkinsonian activity, demonstrating an effect comparable to conventional standard pharmaceutical treatments like Levodopa. The study concludes that these plant extracts warrant further investigation as potential natural therapeutic agents for managing Parkinson’s disease...
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Posted by admin on Apr 30, 2026 in |
Microbial skin infections caused by bacterial and fungal pathogens remain a significant therapeutic challenge, highlighting the need for effective plant-based topical formulations. The present study aimed to develop and optimize an oil-in-water polyherbal cream containing extracts of Cassia fistula, Delonix regia, and Parkinsonia aculeata, and to evaluate its antimicrobial, anti-biofilm, and anti-inflammatory potential. Polyherbal cream formulations were prepared using an oil-in-water emulsification technique and optimized through a 32 factorial design by varying the oil phase and emulsifier concentrations. The optimized formulation (PHC-5) exhibited desirable physicochemical properties, including a mean globule size of 928.7±20.4 nm, polydispersity index 0.27±0.010, viscosity 6528.7±20.4 cps, and spreadability 41.54±2.95 g·cm/s, indicating suitable rheological behavior for topical application. Antimicrobial evaluation demonstrated that the optimized cream showed enhanced activity compared with the crude polyherbal extract. PHC-5 exhibited potent antifungal activity against Candida albicans with MIC 8.0±0.7 µg/mL and MBC 16.0±12.8 µg/mL, showing superior efficacy compared to activity against Escherichia coli. Additionally, the formulation significantly inhibited microbial adhesion and biofilm formation, while time-kill studies confirmed rapid and sustained...
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