Posted by admin on Apr 30, 2022 in |
Embelin was one of active constituents of Embelia ribes Burm. f. Embelin has been reported to possess many pharmacological effects. The studies as was perform to enhance the bioavailability of poorly water soluble embelin, reduce the dose of Embelin, prevent the degradation of Embelin in the GIT. For this, phytosome, a novel drug delivery system, was adopted. Total six Embelin loaded phytosome complex formulations coded as EMBP1, EMBP2, EMBP3, EMBP4, EMBP5 and EMBP6 using soya lecithin and Chitosan in variable ratio were prepared by anti-solvent precipitation method and Rotary evaporation technique. The phytosome was characterized by parameters like percentage yield, particle size determination, entrapment efficiency, scanning electron microscopy (SEM), in-vitro release studies and establish drug release kinetic studies. Among six formulations, the Formulation EMBP5 well optimized. EMBP5 exhibits lowest 345.45 ±1.231 diameter. The entrapment efficiency of Embelin loaded phytosome complex varies from 64.99 ± 1.546 to 81.78 ± 1.151%. Embelin loaded phytosome complex formulation (EMBP5) exhibits highest of 81.78 ± 1.151% entrapment efficiency. SEM photomicrographs of optimized formulation (EMBP5)...
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Posted by admin on Apr 30, 2022 in |
With a view to enhancing endogenous knowledge about plants, the present study has been aimed at developing and standardizing dosage forms based on the aqueous extract of Morinda lucida Benth, a plant with hypoglycaemic anti-hyperglycaemic properties. After the aqueous extraction of the leaves of this plant, by maceration, phytochemical screening was carried out on a TLC plate by using the method of Wagner and Bladt (1996) then three capsule formulations were produced (F1, F2 and F3). Different pharmacotechnical tests were conducted according to the European Pharmacopoeia (Eur. Ph.). The presence of alkaloids, flavonoids and saponosids in the aqueous extract attests to its hypoglycaemic and anti-hyperglycaemic properties. Likewise, their presence in the capsules gives them these same properties and shows the neutrality of the used excipients on the phytochemical’s compounds of the extract. The average capsule masses are 190.525 mg, 250.04 mg, and 381.54 mg, respectively, for the formulas F1, F2, and F3 capsules. The polyphenols that were used as a tracker in the aqueous extract did not show a...
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Posted by admin on Apr 30, 2022 in |
Background and Objectives: A sper requisition of current regulatory requirements, a simple, rapid, and sensitive method by 33 factorial QbD approach was established and validated for Pioglitazone (PGZ) Glimepiride (GPR) by RP-HPLC. Method: A simple RP-HPLC method has been developed and validated with different parameters such as linearity, precision, repeatability, LOD, LOQ, accuracy as per International Conference for Harmonisation guidelines (Q2R1). Statistical data analysis was done for data obtained from different aliquots Runs on Agilent Tech. Gradient System with Autoinjector, UV (DAD) & Gradient Detector. Results: Equipped with Reverse Phase (Agilent) C18 column (4.6 mm × 100 mm; 2.5µm), a 20µl injection loop and UV730D Absorbance detector at 231nm wavelength and running chemstation 10.1 software and drugs along with degradants were separated via Methanol: (0.1% OPA) Water (70:30) of pH 3.2 as mobile phase setting flow rate 0.7 ml/min at ambient temperature. The developed method was found linear over the concentration range of 15-75 μg/ml for PGZ and 2-10 μg/ml for GPR, while detection and quantitation limit was found...
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Posted by admin on Apr 30, 2022 in |
The discovery of alternative medications in diabetes management is of huge importance to achieve better safety and efficacy. The natural antioxidant and carbohydrate hydrolyzing enzyme inhibitors are gaining too much importance in the management of diabetes. Lack of scientific data is available on antioxidant and antidiabetic activities on root extract of Spermadicyton suaveolens. Therefore, we aimed to investigate the in-vitro antioxidant and α- amylase potential of Spermadicyton suaveolens. The roots were extracted by the successive Soxhlet extraction process. The extracts were evaluated for the presence of chemical constituents. Besides, the extracts were assessed for their antioxidant potential using a DPPH assay and α- amylase assay by the DNSA method. Phytochemical analysis acknowledged the presence of secondary metabolites alkaloid, phenol, saponins, steroids respectively. All the extracts showed moderate to high antioxidant and enzyme inhibition potential. Amongst all extracts, ethanolic extract showed the highest free radical scavenging potential (IC50= 324 mg/mL). Moreover, the ethanolic extract also showed better α- amylase enzyme inhibition action (IC50= 602 mg/mL). The finding from the study...
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Posted by admin on Apr 30, 2022 in |
Medicinal plants abound with many phytochemicals that are effective in representing lots of pharmacological activities. The current study aimed at investigating the phytochemical and pharmacological activity of Ethanolic extract of Capparis moonii Wight. The analgesic activity was examined by Eddy’s hot plate method and the acetic acid-induced writhing method. In Eddy’s Hot plate method, after oral administration of EECM at doses of (50, 100, and 150 mg/kg body weight), at the end of the experiment i.e., at 120 min, the percent MPA was 137.70 ± 2.511, 166.99 ± 2.511 and 211.83±10.648% respectively; whereas the reference drug Pentazocine displayed 288.54±10.379% MPA at the dose of 10 mg/kg as compared to the control, and the results were statistically significant (p < 0.01). In the acetic acid-induced writhing test, after oral administration of EECM at doses of (50, 100, and 150 mg/kg body weight), the percent inhibition was 27.08±1.098, 47.62±4.113, and 71.75 ± 3.127%, respectively. In contrast, the reference drug Ibuprofen displayed 77.70±1.180% inhibition at the dose of 100 mg/kg as compared...
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