Posted by admin on Mar 31, 2022 in |
Alzheimer’s is a degenerative brain disease associated with memory depletion and mild cognitive dysfunction, leading to dementia. Today’s world attempts to treat various ailments have increased with medical advancements. There is still considerable research into medications capable of preventing or at least effectively altering the trajectory of AD. Medicinal plants play a major role in Alzheimer’s and memory loss control. Ayurveda, homeopathy, Siddha & Unani medicine systems are the main conventional therapeutic approaches. In animal studies, AD caused by chemical compounds may be helpful in deeper understanding the mechanism of disease and AD treatment. The anticholinergic drug Scopolamine induces amnesia in rodents. In the present study, the efficacy of an Extract of Hylocereus undatus (HUFE) was evaluated against scopolamine-induced Alzheimer in the Wistar albino rat. Donepezil at a dose of 2.5 mg/kg, HUFE was given in rat at a dose of 100 mg/kg body weight, 200 mg/kg body weight, and 300 mg/kg body weight. The anti-Alzheimer activity was assessed by Morris water maze, novel object recognition test, and Y-maze. And...
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Posted by admin on Mar 31, 2022 in |
In this present work, BCS class II Candesartan celexitil, as an angiotensin receptor blocker used mainly for the treatment of high blood pressure and congestive heart failure, was successfully loaded in the solid lipid nanoparticles (SLNs) by using hot high-speed homogenization method. The SLN formulations were prepared and optimized by Box Benhken design study. The SLN was characterized by Nanophox size analyzer and Delsa nano C zetameter. The SLN was also evaluated for particle size, zeta potential, entrapment efficiency, drug loading, surface morphology, and in-vitro dissolution study. The average particle size, zeta potential, percentage entrapment efficiency, and drug loading were found to be 177nm, -8.23 mV, 95.72 %, and 8.23 %, respectively. The dissolution study of SLN showed 92.07 % released in six hours compared to 46.89% release from the pure drug, which indicates a significant improvement in the bioavailability. The release of the drug from SLN showed zero-order kinetics. The stability study was also carried out and found to be stable after three...
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Posted by admin on Mar 31, 2022 in |
Objectives: To assess the risk factors, opportunistic infections (OI’s), prescribing patterns along with ADRs, medication adherence, and quality of life (QoL) among HIV patients. Methods: This is an Ambi-directional cohort study conducted at the Government hospital, Bhimavaram, for 6 months from July 2019 to December 2019, including 201 HIV patients’ data. The data were analyzed using GraphPad Prism 8.3.0. Descriptive statistics & paired t-test were employed to assess risk factors, OIs, prescribing patterns, and QoL, respectively. Results: Out of 201 patients. Heterosexuality (96%) was found to be a predominant risk factor in this study. Between type-1 and type 2 HIV patients, Tenofovir Disoproxil Fumarate/ Lamivudine & Efavirenz (TLE) and Tenofovir Disoproxil Fumarate/ Lamivudine/ Lopinavir/ Ritonavir (TL/ATV/r) were the first-line and second-line therapies respectively in type-1 patients; however, TL/LPV/r was reserved for type 2 individuals. Among 201 patients, 55 patients were reported with 60 ADR’s and the predominant ADR was found to be rashes (36%). Approximately 76% were reported with a history of OI’s, the most prevalent being TB (39%)....
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Posted by admin on Mar 31, 2022 in |
Electrospinning is the fiber-forming process using an electric field where electrostatic forces are employed. By this process, continuous nanofibers range from 0.01 to 10 micrometers can be obtained. Nanofibers produced by the electrospinning technique has application in various fields such as tissue engineering, wound dressing, filtration, protective clothing, drug delivery, and sensor applications. This study aimed to develop a novel bio medicated nanofibrous scaffold for wound dressing applications. Nanofiber of polyvinyl alcohol and sodium alginate loaded with silver sulphadiazine were successfully prepared by the electrospinning method. The formulations were subjected to various physicochemical evaluations such as weight variation, surface pH, folding endurance, moisture evaluation studies, biodegradability, and in vitro drug release studies. All the prepared nanofibers were found to be transparent, flexible with a smooth surface. The physicochemical characteristics of Medicated nanofibers were satisfactory concerning weight variation, surface pH, folding endurance, moisture loss, and moisture uptake studies. The drug entrapment was in the acceptable range for all the formulations, indicating a uniform distribution of the drug. Nanofibers prepared using...
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Posted by admin on Mar 31, 2022 in |
Background: In Ayurvedic literature, Aloe vera, turmeric, honey, karanj oil, and cow ghee are documented for medicinal properties like anti-infective, anti-inflammatory, anti-oxidant, anti-coagulant and wound recovery. Objective: In this study, we aimed to evaluate the efficacy of a topical gel containing Aloe vera extract, turmeric, honey, karanj oil, and cow ghee for wound healing. Methods: Topical gel was prepared and evaluated for skin irritation and efficacy. Skin irritation studies were performed on rabbits according to OECD guidelines 402. Wound healing activity was performed on Wistar rats in the excision wound model, incision wound model, and burn injury model. Results: Treatment with formulation significantly ameliorated wounds compared to the vehicle control group in each wound injury model. Efficacy was comparable to the standard which was confirmed by amelioration of wound contraction, increase in tensile strength, attenuation of inflammatory cytokines TNF-α, IL-6, IL-10 and histological studies. Skin irritation studies on rabbits showed that formulation is non-irritant. Conclusion: In the topical gel used in this experiment showed enhanced wound healing properties in...
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