Posted by admin on Feb 28, 2022 in |
Doravirine is an HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI). The aim of the present investigation was to develop a self-nanoemulsifying drug delivery system (SNEDDS) to enhance the solubility and dissolution of poorly water-soluble doravirine. The solubility of doravirinein various oils was determined to identify the oil phase of SNEDDS. Various surfactants and co-surfactants were screened for their ability to emulsify the selected oil. A ternary phase diagram was constructed to identify the efficient self-emulsifying region. The optimized SNEDDS formulation (F8) contained drug (100 mg), neobee M5 (22.2%), caproic acid (58.2%) and PEG 600 (19.4%). The SNEDDS was further evaluated for its robustness, turbidity, % drug content, entrapment efficiency, droplet size, and zeta potential. The optimized formulation of drug-loaded SNEDDS exhibited 98% entrapment efficiency, 99% drug content and 99% in-vitro drug release in 60 min as compared with the plain drug, which had a limited dissolution rate (31%). The particle size for the optimized formulation of SNEDDS (F8) was found to be 67.8 nm with PDI 0.173. The negative value...
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Posted by admin on Feb 28, 2022 in |
Background: Satranidazole is a class II drug per biopharmaceutical classification systems with poor aqueous solubility and antiprotozoal and anti-bacterial properties. Aim: Therefore, the purpose of the present study was to enhance the solubility of Satranidazole using a self-emulsified drug delivery system (SEDDS). Methods: SEDDS was prepared using Satranidazole (10 mg) and dissolved in the oil phase, i.e., rice bran oil and GMO (1:9). The co-surfactant, propionic acid, was added to the oil phase, and then Tween 80 was added with continuous stirring. The mixture was allowed to homogenize at 40 °C for 24 h and was stored in a stoppered glass vial until further evaluation. The total amount of the mixture was kept constant at 0.37 ml to be filled in size 2 capsules for dissolution study. Physico-Chemical Evaluation: Four SEDDS formulations were prepared (F-1 to F-4) and evaluated for droplet size analysis, stability studies, zeta potential, drug content and in-vitro drug release. Results: Based on self-emulsification time & dispersibility, droplet size analysis, drug content and in vitro drug...
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Posted by admin on Feb 28, 2022 in |
Irrational use of medicines is a major problem worldwide. In surgical patients, a greater number of drugs are prescribed So, evaluating prescribing patterns of various medications in surgical inpatients would enable identifying the presence of irrational use, thereby paving a way to rational prescribing. A prospective observational study was conducted in a secondary care hospital for six months. The general surgery, gynecology and orthopedic wards were included in the study. Descriptive statistics were used to assess drug utilization patterns and measure drug use indicators. A total of 97 patients admitted to the orthopedic, general surgery, and gynecology wards were enrolled in the study. The most commonly prescribed medications were Operation theatre (OT) medications, analgesics, Gastrointestinal tract(GIT) related medicines, antimicrobial agents (AMA), and their percentage use was 29.47%, 16.44%, 16.24%, 12.03%, respectively. Based on WHO core prescribing indicators, the average number of drugs per encounter was 15.4, the drugs prescribed from WHO-EML (World Health Organization- Essential Medicines List) were 29.87%, and the total number of prescriptions with injection was 95.8%....
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Posted by admin on Feb 28, 2022 in |
The present study aims at analyzing the efficiency of allicin, agarlic derived phytochemical or neutraceutical in elevating the activities of various enzymic antioxidants on its treatment to cultured breast cancer cell lines. In the experimental work, cultured breast cancer cell lines were treated with different doses of allicin, and through standardized protocols, the cell lines were assayed for the activities of enzymic antioxidants such as Peroxidase, Superoxide dismutase, Catalase and Glutathione S Transferase as compared to untreated control. It was found that allicin treatment significantly increased the activities of the said enzymic antioxidants as compared to control. This study demonstrates the antioxidant potential of allicin in cancer cells, showing decreased antioxidant activity as a characteristic feature of cancer cells, leading to severe oxidation-induced damage. The study also proposes future prospects in the areas of cancer research and therapy to cobble for the designing of targeted plant-based therapies that are easily available and are cost effective in comparison to synthetic therapeutic chemicals and that too without side...
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Posted by admin on Feb 28, 2022 in |
There is an urgent need to replace the injection currently used for low molecular weight heparin (LMWH) multi-dose therapy with a non-invasive delivery device. In this study, unsaturated polyester resin and peroxide were used to fabricate microneedle mould by using 3M microneedle. Dissolving microneedle arrays transdermal patch was prepared by using 20 % w/v polymers of PVA and PVP (polyvinyl alcohol and polyvinyl pyrrolidone) and active drug 20 mg (IU) low molecular weight heparin (LMWH). The physicochemical compatibility of the drug and the polymers was studied by infrared spectroscopy suggested the absence of any incompatibility. Formulated transdermal films were physically evaluated with regard to weight variation, drug content, folding endurance, percentage of moisture content and water uptake. All prepared formulations indicated good physical stability. In-vitro permeation studies of formulations were performed by using Franz diffusion cells. The formulation prepared with PVP: PVA 1:2 showed best ex-vivo skin permeation through rat skin (Wistar rat) as compared to all other formulations. The release profile of the optimized formulation F2 (R2 =...
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