Posted by admin on Nov 30, 2021 in |
In the present study, a modified glassy carbon electrode by a conductive film containing, i.e., functionalized multi-walled carbon nanotubes (f-MWCNTs) was selected for the determination of atracurium besilate (in short ACB), an anesthetic drug by applying the cyclic voltammetry (CV) and differential pulse anodic adsorptive stripping voltammetry (DP-AASV) techniques. Herein, nanomaterials suspension is prepared and further examined by field emission scanning electron microscopy (FESEM) analytical technique. All the effective electrochemical parameters for the detection of ACB drugs were optimized, and the oxidation peak current (Ip) of the drug was used for monitoring. The obtained results confirmed that the oxidation peak current (Ip) increased linearly by increasing in the concentration range from 1.25×10-7 M to 7.75×10-4 M of ACB. The limit of quantification (LOQ) and limit of detection (LOD) are 52.6 ng/mL and 1.43 ng/mL achieved, respectively. The sensor (nanomaterials modified glassy carbon electrode) revealed extreme sensitivity/sensing towards atracurium besilate (ACB) pharmaceuticals in bulk...
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Posted by admin on Nov 30, 2021 in |
Artificial Intelligence is the simulation of human intelligence. From delivering simple groceries to doorsteps to solving the toughest task in scientists’ lab, it is surrounding human life in all the means. So how can the Pharma industry be untouched in the case of AI?! Artificial Neural Network (ANN) is a type of AI used to solve non-linear problems and predict the output for given input parameters from the training values. In this research work, such generalized ANN is developed to predict drug release from the sustained-release monolithic tablet. It is trained by the backpropagation method under supervised learning. This developed model is evaluated on the basis of RMSE, similarity and dissimilarity factors and can predict the output with the best achieved average error ~0.0095 and R2 0.9953. Such ANNs can be the best combination of experience and intelligence, which can eliminate tedious lab works that can be cost-effective and...
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Posted by admin on Nov 30, 2021 in |
The current research paper was focused on exploiting Plackett-Burman design to screen the effect of eight factors Pregelatinised Starch (A), Crospovidone (B), Microcrystalline Cellulose PH 101 (C), Talc (D), Magnesium Stearate (E), Hydroxy Propyl Methyl Cellulose (F), Hydroxy Propyl Cellulose (G) and Lactose Monohydrate (H) on the release of drugs from the Immediate release DEM Cocrystal tablets prepared by direct compression method. The studies were carried out according to a statistical eight-factor 12 model using STATGRAPHICS XVI software and were subjected to a dissolution analysis at 0.1 N HCl pH 1.2 for determination of drug release. The ANOVA and the residual analysis showed the importance of the model. Pareto charts were generated using Design Expert® for visual identification of the effect of excipients on drug release. The drug release percentage was significantly affected by Crospovidone, Hydroxy propylmethyl cellulose, and microcrystalline cellulose. Plackett Burman could guide the process of reducing the number of experiments to a manageable level...
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Posted by admin on Nov 30, 2021 in |
The aim of this study was to assess the influence of extract of D. brasiliensis (CEDb) on acute liver injuries induced by both acetaminophen, and carbon tetrachloride in mice as an initial step to validate its popular use. A liquid-chromatography method coupled to Mass Spectrometry showed the presence of coumarins dorstenin, bergapten, and psoralene in CEDb. Swiss albino male mice were pre-treated orally with CEDb and then injected with paracetamol and carbon tetrachloride. Animals were sacrificed, and serum was separated for measuring the activity of transaminases and alkaline phosphatase. Increased serum level of aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) induced by both acetaminophen (350 mg/kg i.p.) and CCl4 (1% in sunflower oil v/v, i.p.) administered to mice were attenuated by oral pre-treatment with CEDb (50.0, 100.0, 200.0 and 300.0 mg/kg). In the paracetamol-induced liver injury, the influence of doses of CEDb configured a dose-dependent-like effect. Moreover, in carbon tetrachloride-induced liver injury, a non-dose-dependent effect was observed. Based on these results, we concluded that D. brasiliensis...
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Posted by admin on Nov 30, 2021 in |
The objective of the present research is to enhance the solubility and improve the rate of dissolution of poorly water soluble drug aceclofenac, which belongs to BCS class II. Enhancement of solubility was be achieved by converting the poorly water-soluble drugs into Bionanocomposites (BNCs) by using natural carriers, which ultimately leads to enhance the bioavailability of drug entities. Bionanocomposites (BNCs) were prepared using the microwave-assisted synthesis fusion method, where the drug entities were fused with natural carriers such as Acacia arabica and gond katira. Selection of carriers was done based on their wetting and surfactant properties. The FTIR, DSC studies reveal that there was no any interaction between aceclofenac and Natural carriers. Solubility dissolution studies were carried out to investigate the solubility-enhancing property of the BNCs. In-vitro dissolution studies of prepared aceclofenac’s BNCs were characterized through DSC, SEM, XRD and FTIR. Both the gum were shown less % of swelling index, viscosity and foaming index. From the study, it was found that the developed ten batches of BNCs among...
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