Posted by admin on Dec 31, 2021 in |
Positron emission tomography (PET) imaging has been broadly used in the study of brain damage for a long time. However, PET has been mostly used for the assessment and detection of neural activity after brain damage. Tau proteins play a significant role in a variety of degenerative neurological conditions. Post-mortem neuropathology studies of victims of repeated and severe head trauma have defined a unique spatial expression of neurological tauopathies in these individuals known as chronic traumatic encephalopathy (CTE). The current review assesses the role of tau in head injury, the state of tau radiotracer development, and the potential clinical value of tau-PET derived from head injury studies. There are variations in the binding patterns between different tau radiotracers. Therefore, the present work is commenced with a general review of TBI and CTE, followed by the chronic and acute pathophysiological consequences of TBI. In the following, beta-amyloid, glycolysis, and tau protein radiotracers are assessed critically, considering the most recent and available imaging studies. Considering the scientific relevance of these radiotracers...
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Posted by admin on Nov 30, 2021 in |
Natural products offer great hope in the identification of bioactive compounds and their development into drugs for the treatment of various diseases. The present study aims to evaluate the antioxidant potential of Portunus pelagicus. P. pelagicus (Station-I) possessed 33.14% of inhibition, the highest DPPH activity, whereas Station II and Station III showed 31.42% and 30.85% of inhibition. Portunus pelagicus possessed 3.34% reducing ability at 1000 µg/ml concentration in the present study in station I, station II exhibited 2.62%, and station III shpwed2.55% at 1000 µg/ml concentration. The highest reducing ability was recorded at the station I, compared to stations II and III. The present study revealed that the tissue extract of Portunus pelagicus has antioxidant capacity, and it needs further characterization to improve the pharmacologically active marine natural...
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Posted by admin on Nov 30, 2021 in |
A nafion plus functionalized-multiwalled carbon nanotubes modified glassy carbon electrode (f-MWCNTs/GCE) was developed for the determination of anti-depressant drug mirtazapine (MIR). The electro-chemical behavior of the molecule was investigated employing cyclic voltammetry (CV), chronocoulometry (CC), and differential pulse adsorptive stripping voltammetry (DPASV). The surface morphology of the electrodes has been studied through scanning electron microscopy (SEM). These studies revealed that the oxidation of MIR is facilitated at f-MWCNTs/GCE. After optimization of analytical conditions employing this electrode at pH 10.5 of 0.04M carbonate buffer for MIR, the peak currents were found to be linearly with different concentrations in the range of 6.72 × 10-6 M to 3.74 × 10-4 M for MIR. The detection limits were obtained of 32.45 × 10-8 M and 9.45 × 10-7 M for MIR, using DP-AAdSV. The prepared modified electrode has several advantages, such as simple in preparation method, showed high sensitivity with very low detection limits, and gave excellent reproducibility. The proposed method was also employed for the determination of MIR in pharmaceutical formulations,...
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Posted by admin on Nov 30, 2021 in |
In pharmaceutical research, the transdermal route of drug delivery has gained great interest, Trasferosomes is a novel vesicular drug carrier system that is composed of water, surfactant, and phospholipids; these were introduced in the early 1990s. The mechanism on which drugs absorb through skin is “osmotic gradient”. Transferosomes, when applied on the skin surface it diffuses into skin layers and provides smoothness and hydration to the skin, which facilitates drug absorption. The transferosomal gel of ketoconazole was prepared with the aim to achieve higher diffusion through the skin for the treatment of acne with minimum or no side effects. The formulations were prepared by the reverse-phase evaporation method. Formulations were prepared by varying the ratio of soya lecithin and cholesterol by maintaining room...
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Posted by admin on Nov 30, 2021 in |
The present work deals with the development and validation of a novel, robust, precise, and accurate UV-spectrophotometric method for the estimation of canagliflozin in bulk and formulation using the principle of Analytical Quality by Design (AQbD). A central composite design (CCD) was employed for initial parameter screening and method optimization. Different statistical parameters were evaluated to decide the appropriateness of experimental data. Canagliflozin shows an absorption maximum at 290 nm using methanol and water. Factor screening slit width and sampling interval were identified as critical method variables, which were further evaluated by a CCD. Design Expert (Version 12.0.6.0, Stat-Ease Inc., Minneapolis, MN USA) software was used for the method optimization and generation of design space Good linearity was obtained for canagliflozin in the range of 5-25 μg/mL with R2> 0.9989. The method was found to be accurate with good average % recovery. The developed method was validated as per ICH guidelines. Based on AQbD development of the Spectrophotometric method ensured that quality is built into the method. The method...
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