Posted by admin on Oct 31, 2021 in |
Rosuvastatin is an antihyperlipidemic agent belonging to BCS class II Drugs with low aqueous solubility and high permeability. Objective: To formulate Rosuvastatin nanosuspension by Emulsification solvent diffusion technique by QbD approach and its evaluation. A 2² factorial design was employed to study the effect of independent variables [SLS (X1) and amount of PVP K -30(X2)] and dependent variables [total drug content (Y1) and PDI (Y2)]. Methods: Four nanosuspensions were prepared and evaluated for their saturation solubility, particle size, zeta potential, SEM, TEM, and in-vitro drug release study. Results: The particle size and PDI of all formulations were in a range of 215-38nm & 0.1-0.9, respectively. The drug content was ranged from 69 %-79%. From the design space F1 (SLS 4mg, PVPK-30, 25mg) and based on the mean particle size of 215nm, PDI of 0.2, drug content of 79%, and cumulative drug release 91%, F1 was selected as an optimum formulation with a zeta potential of -35.2mV. Conclusion: It can be concluded that Rosuvastatin formulated as nanosuspension formulation can enhance...
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Posted by admin on Oct 31, 2021 in |
The main objective of this study was to formulate a Sustained release tablet by wet granulation method. A sustained release tablet of trazadone hydrochloride was prepared by using synthetic polymer. The prepared tablets were evaluated for their diameter, thickness, drug content, Hardness, friability, weight variation. The thickness and diameter of the tablet range from 5.43±0.288 to 5.76±0.05 and 09.68±0.577 to 10.04±0.04, respectively. Drug content was studied, and its ranges from 92.03 to 98.60%. Hardness was studied; its ranges 5.5 to 6.5 kg/cm2, Friability ranges 0.71 to 0.95%, Weight variation ranges between 434±1.49 to 460±1.23. FTIR and DSC analysis does not show any interaction of drug with Excipient. The formulation was optimized on the basis of acceptable pre and post-compression parameters. The results of dissolution studies indicated that Batch F4 containing eudragit RL 100 exhibited drug release of 88.06% at the end of 12 h to provide sufficient concentration for achieving satisfactory therapeutic value for an extended period of time. Optimized batch best fitted to Higuchi model. The n value...
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Posted by admin on Oct 31, 2021 in |
The present study aims to formulate and evaluate clopidogrel bisulfate capsule-loaded nanoparticles. Clopidogrel bisulfate nanoparticles were produced by the nano-precipitation method and emulsification solvent evaporation method using ethylcellulose polymer at different ratios and characterized for particle size drug entrapment efficiency dissolution testing scanning electron microscopy imaging (SEM) and compatibility studies (Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). Optimized nanoparticles were filled into capsules with different concentrations of HPMC 4 KM and further evaluated. The prepared nanoparticles characterized and found to be the particle size was ranged from 100-2500 nm, and entrapment efficiency was ranged from 23.88 ± 0.20 % to 90.53 ± 0.31%. Amongst all formulations, F6 and F10 were considered for further optimization showed dissolution 53.20 ± 0.27 and 39.87 ± 0.12 % at the end of the first hour with entrapment efficiency 70% and 79%, respectively. SEM of clopidogrel bisulfate nanoparticles confirmed small particles without aggregation. The particle size of F6 and F10 obtained was 287.6 and 349.8 nm, respectively. Compatibility studies revealed that...
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Posted by admin on Oct 31, 2021 in |
Two monobasic bidentate ligands L1H [2-(5-Bromo-2-dihydro-2-oxo-1H-indol-3-ylidene)hydrazine-carboxamide] and L2H [2-(5-Bromo-2-dihydro-2-oxo-1H-indol-3-ylidene)hydrazinecarbothioamide] were synthesized by the condensation of [2-(5-Bromo-2-dihydro-2-oxo-1H-indol-3-ylidene) with semicarbazide and thiosemcarbazide, which formed a series of complexes with cobalt(II) and nickel(II). The ligands and the metal complexes were characterized based on elemental analysis, IR, UV–Visible, 1HNMR, Mass spectroscopy. Spectral studies revealed that the ligands acted as monobasic bidentate, coordinating to the metal ion through the azomethine nitrogen i.e. >C=N and carbonyl oxygen atom of the isatin moiety. All the Schiff base metal complexes have a mononuclear structure, and the octahedral geometry has been proposed on the basis of spectral studies. The nickel (II) complex Ni (L2) (OAc).3H2O was subjected to XRD studies which revealed a monoclinic crystal system. In vitro, biological screening effects of the compounds were tested against two bacterial species Staphylococcus aureus and Escherichia coli. DNA cleavage and antioxidant activity of the ligands and their respective complexes were also...
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Posted by admin on Oct 31, 2021 in |
Datura (Datura metel Linn.) is a herbaceous leafy annual and short-lived plant of the Solanaceae family. It’s commonly known as Angel’s trumpet, Devils apple, Jimson weed, stinkweed, and Thorn apple. The traditional system of medicine enlightened the importance of Datura metel Linn. of its great medicinal value. The roots, leaves and flowering tops have been used in India for their narcotic and antispasmodic properties in the treatment of numerous ailments and conditions. The juice of fresh leaves is used to relieve the painful swellings. The seeds and root possess anti-diarrheal and are used to treat insanity and fever. All parts of Datura are poisonous in nature, and it’s mentioned under sthavara visha category by Ayurveda. In the present study, roots of Datura, which are less toxic compared to the other parts of the plant, were studied both in raw and purified form. AS the drug, in general, was considered poisonous, purification was done with Ayurveda procedure (Shodhana Samskara) to reduce the toxicity of the noxious drug for its chemical...
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