Posted by admin on Dec 31, 2021 in |
A model of ascending Urinary tract infection (UTI) in rats was developed to study the significance of antibacterial activity of Sphaeranthus indicus L. and compared with standard antibiotic ofloxacin as a positive control. This plant used in folk medicine as a remedy for urinary tract infections is belong to Asteraceae family. Outbred female wistar rats were used throughout the study and Escherichia coli was used as pathogen isolated from the urine of patients suffering from urinary tract infections. Methanolic extract (300 mg/mL) and aqueous extract (300 mg/mL) of Sphaeranthus indicus were administered orally for 15 days. After 15 days of treatment of the infected rats with herb extract, bacterial count in the urine, immunoglobulin G and M levels were estimated, and his pathological changes of kidney, liver, and urinary tract were observed. In the disease control group bacterial infection has increased than that of the normal control group. In the treated group with aqueous extract (300 mg/mL) & methanolic extract (300 mg/mL) bacterial count has decreased considerably. There was...
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Posted by admin on Dec 31, 2021 in |
Introduction: Femur is the key bone among the skeletal remains to determine sex for anatomists, anthropologists, and forensic experts. In the present study, we considered most of the parameters to determine sex from the femur. Methods: We studied eighty-four undamaged, intact femora of unknown sex. The present study were carried out in S. C. B. Medical College Cuttack from December 2019 to April 2020. The parameters, like maximum length, maximum breadth, head circumference, mid-shaft circumference, and vertical diameter femur head, were measured by a goniometer and verniers caliper. Results: From each femur above-mentioned parameters were recorded, and the details were obtained about the mean, Standard Deviation, percentage, and p-Value. Then these details were compared with the findings of other studies to conclude. Conclusion: These measurements show the values are higher in males than females and were statistically highly significant between males and females with a p-value...
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Posted by admin on Dec 31, 2021 in |
Objective: The objective was to study drug-drug interaction between Lornoxicam and oral hypoglycemic agents in normal and Streptozotocin-induced diabetes in rats. Material and Method: The protocol was blueprinted in two phases. In the first segment, the influence of Glibenclamide (0.7mg/kg/p.o.) and Glipizide (1.05mg/kg/p.o.) once daily on blood glucose levels in normoglycemic rats were studied and then the influence of Lornoxicam (1.64 mg/kg/p.o. once daily) pre-treatment on the hypoglycemic activity studied. Along with, the influence of Lornoxicam treatment for seven consecutive days (per se effect) on blood glucose levels was also studied in normoglycemic rats. In the second phase of the study, Streptozotocin-induced diabetic rats were used to assess the influence of Lornoxicam pre-treatment on Glibenclamide and Glipizide induced hypoglycemic effect in pathophysiological conditions. Blood samples were collected at accepted hiatus of 0.0, 0.5, 1.0, 2.0, 4.0, 8.0, 12.0, 18.0 and 24.0 h subsequent to drug treatment. All blood samples were evaluated for plasma glucose by the glucose oxidase peroxidase method (GOD/POD). Results: The findings suggested that Lornoxicam influences the hypoglycemic action of...
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Posted by admin on Dec 31, 2021 in |
The aim of this study is to evaluate metformin and insulin effects on metabolic disorders and oxydatif stress markers, in Algerian men with T2D, in order to recommend the best treatment, which can minimize diabetes complications and recommend/or not a combination between metformin and insulin. Patients and Methods: We made this study on 120 subjects men divided into four groups (30 healthy control, 30 T2D without treatment, 30 T2D with metformin, and 30 T2D with insulin). Blood samples are collected for the determination of biochemical parameters (glucose, triglycerides, and cholesterol, high and low-density lipoprotein cholesterol) and oxidative markers (superoxide anion, nitric oxide, malondialdehyde, carbonyl proteins, oxygen radical absorbance capacity, vitamin C, catalase, glutathione). Results: Compared with healthy subjects, diabetic patients had altered lipid levels (cholesterol, triglycerides, LDL cholesterol) and high levels of pro-oxidant intra-cellular markers (O2•-, CP and MDA) associated to low concentrations of anti-oxidants (Vitamin C, catalase, and GSH). Our results show that insulin reduces more lipid parameters than metformin, moreover, the oxidant/antioxidant status became normal in patients...
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Posted by admin on Dec 31, 2021 in |
For the last few centuries, the leaves of Stevia rebaudiana have been used as an efficient substitute for sugar due to its sweetness and almost negligible Glycemic effects. The study concentrates on the pharmacognostic aspects and other anatomical characteristics of the leaves. The study is performed on the plant leaves collected from the medicinal plant garden of Birla Institute of Technology, Mesra, Ranchi, India. The study is purely concentrated on finding various morphological characteristics and microscopic characteristics of the leaves. The microscopic characterization includes understanding the various anatomical characters of the leaves as well as the identification of the various diagnostic characteristics related to the leaves. Leaf constants, such as the Stomatal index, Stomatal number, Palisade ratio, vein-islet, and vein termination numbers, were also determined. The study also aims to determine various physicochemical parameters such as Moisture content, total ash, and extractive values. Preliminary phytochemical characterization of the aqueous extract of the leaves was also...
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