Posted by admin on Dec 31, 2021 in |
Hugonia mystax is a woody evergreen plant that grows in the dry forest areas of India and Sri Lanka. Often found in the forests of Kerala and Tamil Nadu in southern India. It is locally known as modirakanni (tamil) and kamsamaraha and tribals from Tamil Nadu, India, have used it in primary health care. The plant parts are used ethnobotanically to treat rheumatism, skin diseases and inflammations, snake bites, fever, and worm infestation. Hugonia mystax is an antibiotic, anthelmintic, febrifuge, astringent, peptic ulcer and verminosis remedy. Hugonia mystax has been practising herbal medicine for a long time. This plant is a member of the linaceae family and is an essential medicinal plant in Indian medicine. To evaluate the extractive values, powdered materials were subjected to successive extractions with ethanol using the Soxhlet process. The existence of several compounds such as flavonoids, phenolic elements, steroids, tannins, saponins, terpenoids, and carbohydrates was revealed by qualitative phytochemical screening of the ethanolic extracts of the leaves, as well as GC-MS analysis to examine...
Read More
Posted by admin on Dec 31, 2021 in |
Patients with psychotic disorders often require long-term and intensive treatment. Several drug utilization studies have been carried out using WHO (World Health Organization) prescribing indicators, but these studies are deficient for psychiatry patients in India. To analyze antipsychotic prescriptions according to WHO core prescribing indicators and identify various techniques used for switching over from one antipsychotic to another, a cross-sectional, observational study was conducted with one year and six months duration. 128 patients were enrolled who fulfilled the inclusion criteria and gave written informed consent. This study revealed male (53.91%) predominance over female patients (46.09%). The average number of drugs prescribed per encounter was 4.56. The percentage of drugs prescribed by generic name was 48.79%, and 52.06% of drugs were prescribed from the essential drug list. Atypical antipsychotics (53.28%) were prescribed more than typical antipsychotics (46.71%). 56.25% of patients were treated with monotherapy, and 43.75% patients were treated with polytherapy. Switching over of antipsychotics was seen in 33 (25.78%) patients. The most commonly used technique for switching was immediate/abrupt...
Read More
Posted by admin on Dec 31, 2021 in |
The reporting of adverse drug reactions after taking any medicines is very much essential to establish a safe patient profile for drugs. The co-infection of HIV and TB has been a major concern for the healthcare system, and the various drugs interaction from taking ART and ATT should be highlighted to avoid unwanted reactions. The present study was conducted in a hospital set up for a period of one year in the ART center, where the ADR cases were recorded from the HIV patients suffering from tuberculosis. During the study, 135 patients co-infected with HIV and TB were analyzed from which a total 135 adverse drug reactions were collected and recorded. It is observed that rash, raised liver function, fever, peripheral neuropathy, and anaemia are the most common adverse drug reactions from the concomitant therapy of ART and ATT. From the study, 13 different types of ADRs were reported in patients on the ART and ATT therapy. It is important to do the causality assessment according to the WHO-UMC...
Read More
Posted by admin on Dec 31, 2021 in |
The aim of the study to compare the efficacy of vildagliptin (50 mg) and glimepiride (2 mg) metformin (500 mg) for type-2 diabetes mellitus. Vildagliptin and glimepiride are found to be regulated the blood plasma glucose by stimulating beta cell in the pancreas. The treatment course duration of 34 weeks comparative observational study was conducted over 160 patients with type-2 diabetes mellitus was recognized. Group A (n=80) was treated with vildagliptin (50 mg) with a combination of metformin (500 mg). Group B (n = 80) was treated with glimepiride (2 mg) with a combination of metformin (500 mg) with fixed dosage was given daily twice. The baseline of HbA1c from > 7.0% to <10.5%. The tests were performed by the help of vitros 250 and sysmex XN 1000 and 350. Thus, the performance of the t-test was found to play a significant role. Group A and group B have shown a greater reduction in plasma glucose fasting plasma glucose reduced up to 47.9mg/dl (p<0.000) in vildagliptin group versus glimepiride...
Read More
Posted by admin on Dec 31, 2021 in |
Dental caries is considered one of the major oral health issues throughout the world. Synthetic drugs and antibiotics have major side effects and can develop resistance. Ficus benghalensis F. benghalensis is a plant with enormous established pharmaceutical properties. The present study was designed to evaluate the antimicrobial activity of water, and ethanolic extracts of F. Benghalensis leaves against human dental pathogens. The isolated dental pathogens are Streptococcus mutans, Lactobacillus, Klebsiella pneumonia, and Candida albicans. The cup plate method was used to evaluate the antimicrobial activity of water, and ethanolic extracts of F. benghalensis leaves against the isolated microbes. Data were analyzed in one-way variance analysis. The water extract of F. benghalensis leaves was active against Klebsiella pneumonia and Candida albicans. The ethanolic extract of F. benghalensis leaves was active against all the Streptococcus mutans, Lactobacillus, Klebsiella pneumonia and Candida albicans. Since both the water and ethanolic extracts of F. benghalensis leaves shows maximum antimicrobial activity against Klebsiella pneumonia with a diameter of inhibition zones 20 mm and 23 mm...
Read More
