Posted by admin on Aug 31, 2021 in |
In the present study, to develop a novel flash release fast dissolving oral film of candesartan cilexetil to achieve rapid dissolution and further improve the bioavailability of the drug. Also, to resolve the swallowing problems in pediatrics, geriatric patients by rapid dissolution in saliva and improve the patient compliance. Fast dissolving flash release oral flim of candesartan cilexetil was formulated using HPMCE5, HPMCE15 and HPMCK15 as film-forming polymers. Glycerol, polyethylene glycol and propylene glycol were used as a plasticizer by solvent casting method and found to satisfy the mouth dissolving film and other film parameters. The formulated films of candesartan cilexetil were evaluated for parameters like thickness, weight variation, folding endurance, SEM, surface pH disintegration time, drug content, in-vitro dissolution studies and kinetics studies. The in-vitro disintegration time of the optimized batch F5 was found to be 56 ± 0.12 sec. The films exhibited satisfactory thickness and folding endurance. The optimized batch F5 (HPMCE15) showed a faster disintegrating time, showing 96.02 ± 0.49 drug release within 30 min. The...
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Posted by admin on Aug 31, 2021 in |
Theoretical studies on two previously synthesized 3-((2, 4-dinitrophenyl) amino)-5-methyl-2-phenylimidazolidin-4- one (1) and 3-((2,4-dinitrophenyl) amino)-2-phenylimidazolidin-4- one (2) were carried out using the Density Functional Theory method. The geometrical parameters of the molecules in the ground state was optimized at the DFT-B3LYP level of theory and ab initio method using 6-31G (d,p) basis set. Bond angle and bond length were calculated from optimized geometry. The calculated bond angle and bond length indicated that both the molecules are planar. Various quantum chemical parameters such as dipole moment (μ), energy difference (ΔE), softness (S) and global hardness (η), highest occupied molecular orbital (EHOMO) and lowest occupied molecular orbital (ELUMO) has been calculated in order to elucidate the adsorption and corrosion inhibition behavior of the molecules. The anticorrosive ability of the molecules was also...
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Posted by admin on Aug 31, 2021 in |
Our aim is to observe the impact of Levothyroxine supplement on Triglycerides and Very- low-density lipoproteins in Hypothyroid patients. This study is to observe the incidence of Dyslipidemia condition (elevated TG’s, VLDL levels) and the impact of levothyroxine supplement on TG’s and VLDL in hypothyroidism patients. Our current study is an observational study, which involves observation of hypothyroid patients and their TSH levels, TG’s, VLDL levels. The results showed that, out of 150 patients, 65 people came under group I, and 85 people were under group II. In Group-I, patients with elevated TG’s and VLDL’s were found to be 10(15. 38%), 6(9.23%) respectively. Similarly, in Group-II, patients with elevated TG’s and VLDL̓s were found to be 46(54.11%), 38(65.51%), respectively. Finally, we conclude that treatment with levothyroxine in patients with a history of hypothyroidism above 5 years resulted in the maintenance of normal TSH levels, TG’s and VLDL levels when compared with those patients who had a history of hypothyroidism below 5 years with elevated TSH, TG’s and VLDL...
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Posted by admin on Aug 31, 2021 in |
Plants are rich sources of chemical compounds of high therapeutic value and screening plants for such bioactive compounds is the order of the day. First and foremost, it appears sensible to probe into the chemical reserves of abundantly available but rarely studied plants. The present study was carried out to determine the presence of phytochemicals in a common roadside weed, Cleome burmanni using Gas Chromatography- Mass Spectrometry (GC-MS) analysis. The mass spectrum of the crude methanol extract was compared with the available library sources (NIST08 LIB, WILEY8 LIB). GC-MS analysis of the methanol extract of C. burmanni revealed the presence of 24 compounds. The compounds along with their retention time, molecular weight, molecular formula and peak area have been recorded. Cholest-4-en-3-one (19.05%) was the major compound detected followed by Urs-12-en-28-al (17.98%), Lup-20(29)-en-3-one (14.87%), 1-(1-Butynyl) cyclopentanol (13.47%) and 4, 22-stigmastadiene-3-one (10.77%). Remaining 19 compounds were detected in low quantities. Almost all the constituents were reported to possess specific biological...
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Posted by admin on Aug 31, 2021 in |
Context: Drug-drug interactions (DDIs) are frequently observed in hospitalized cardiac patients and associated with alteration in the effectiveness of cardiovascular therapy. Aim: The study was conducted to identify the incidence and nature of DDIs and their associated risk factors among patients with cardiovascular disease (CVD). Materials and Method: A prospective interventional study was conducted between August 2018 and April 2019 in the Department of Cardiology of a tertiary care South Indian hospital. Patients admitted with CVD on a minimum of two medications were enrolled in the study and their prescriptions were evaluated for DDIs using Micromedex interaction checker version 2.8. Results: A total of 258 patients with CVD were enrolled in the study with a mean age of 60.11±12.07 years. On average, each patient was prescribed 11.35±3.30 medications. The incidence of potential DDIs (pDDIs) was 99.61%, with 7.59±4.10 as a mean number of pDDIs per prescription. The majority of the interactions were significant in severity (50.69%), pharmacodynamic (68.24%) in nature, of unspecified onset (69.97%), and with fair documentation status...
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