Posted by admin on Nov 30, 2021 in |
The aim of this study was to assess the influence of extract of D. brasiliensis (CEDb) on acute liver injuries induced by both acetaminophen, and carbon tetrachloride in mice as an initial step to validate its popular use. A liquid-chromatography method coupled to Mass Spectrometry showed the presence of coumarins dorstenin, bergapten, and psoralene in CEDb. Swiss albino male mice were pre-treated orally with CEDb and then injected with paracetamol and carbon tetrachloride. Animals were sacrificed, and serum was separated for measuring the activity of transaminases and alkaline phosphatase. Increased serum level of aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) induced by both acetaminophen (350 mg/kg i.p.) and CCl4 (1% in sunflower oil v/v, i.p.) administered to mice were attenuated by oral pre-treatment with CEDb (50.0, 100.0, 200.0 and 300.0 mg/kg). In the paracetamol-induced liver injury, the influence of doses of CEDb configured a dose-dependent-like effect. Moreover, in carbon tetrachloride-induced liver injury, a non-dose-dependent effect was observed. Based on these results, we concluded that D. brasiliensis...
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Posted by admin on Nov 30, 2021 in |
The objective of the present research is to enhance the solubility and improve the rate of dissolution of poorly water soluble drug aceclofenac, which belongs to BCS class II. Enhancement of solubility was be achieved by converting the poorly water-soluble drugs into Bionanocomposites (BNCs) by using natural carriers, which ultimately leads to enhance the bioavailability of drug entities. Bionanocomposites (BNCs) were prepared using the microwave-assisted synthesis fusion method, where the drug entities were fused with natural carriers such as Acacia arabica and gond katira. Selection of carriers was done based on their wetting and surfactant properties. The FTIR, DSC studies reveal that there was no any interaction between aceclofenac and Natural carriers. Solubility dissolution studies were carried out to investigate the solubility-enhancing property of the BNCs. In-vitro dissolution studies of prepared aceclofenac’s BNCs were characterized through DSC, SEM, XRD and FTIR. Both the gum were shown less % of swelling index, viscosity and foaming index. From the study, it was found that the developed ten batches of BNCs among...
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Posted by admin on Nov 30, 2021 in |
Milk and milk products are nutritious food items containing numerous essential nutrients. This study was carried out to determine the influence of variable season on profiling of amino acid and protein content from 90 bovine milk collected (March 2018 to February 2019) samples belongs to four tehsils of Singrauli district. The most abundant amino acid was glutamic acid, followed by proline and leucine. Concentration of amino acid in cow milk was found to be in order of Glycine < histidine < alanine < methionine < isoleucine < phenylalanine < threonine < tyrosine < serine < lysine < valine and aspartic acid < arginine < leucine < proline < glutamic acid. Amino acid status in buffalo milk sample was found in order Glycine < histidine < methionine < alanine < phenylalanine < isoleucine < threonine < arginine < tyrosine < serine and lysine < aspartic acid < valine < leucine < proline < glutamic acid. Average protein content comparison, results, in rainy season, maximum protein content was in Deosar and...
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Posted by admin on Nov 30, 2021 in |
Gastric acid hypersecretion is a major cause of gastric complications like hypergastrinemia, hyperhistaminemia and Zollinger-Ellison syndrome. Out of various drug treatments used, H2-receptor antagonists possess some limitations, such as the development of tolerance when used for a long period, having a short duration of action, and no complete inhibition of acid secretion in response to a meal. In the case of PPIs they are showing the slow onset of action, short half-life, incomplete acid suppression, and differences in effectiveness in patients due to CYP2C19 (Cytochrome P2C19) metabolism To overcome these limitations, other alternative better therapeutic agents should be focused. Potassium-competitive acid blockers (P-CABs) or Acid pump antagonists (APAs) are new H+/K+-ATPase inhibitors that can exhibit almost complete inhibition of gastric acid secretion through reversible and K+-competitive inhibition of the enzyme. In our research work, We are reporting the synthetic methods of novel Quinazoline derivatives and their preliminary gastric acid secretion suppression action. Proposed compounds belong to two Series of N-((3-Benzamido-4-oxo-3, 4-dihydroquinazolin 2-yl) methyl)-N- (substituted) phenyl-benzamides and were prepared, and...
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Posted by admin on Nov 30, 2021 in |
Candesartan is an angiotensin receptor blocker, used as an anti-hypertensive drug. It is available in the salt form of cilexetil i.e.; Candesartan cilexetil belongs to class II of the Biopharmaceutical classification system. It is a poorly soluble drug, and the bioavailability is 15%. The intention of the study is to improve the solubility of the poorly soluble drug, Candesartan cilexetil using the inclusion complexation technique with γ-CD as a complexing agent. Complexation is the association between two or more molecules to form a non-covalent-based complex that has a higher solubility than the drug itself. Binary mixtures of Candesartan cilexetil were prepared with three different techniques (Physical Mixture, Kneading method, Solvent evaporation method)in three different ratios (1:1, 1:2, 1:3). The prepared complexes were analyzed using Fourier transform infrared spectroscopy. In-vitro dissolution studies were performed for all the prepared complexes by different methods in different ratios in order to define the most appropriate ratio and preparation...
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