Posted by admin on Sep 30, 2021 in |
The goal of the research is to analyze the antiparkinsonian activity of hydroalcoholic extract of the stems of Capparis Decidua (HECD). Themost common neurodegenerative condition which stand second is Parkinson. It is reported by dopaminergic neuron loss in the striatum’s substantia nigra & dopamine loss (DA). Capparis Decidua plant is used as anti-inflammatory, laxative, anti-diabetic, anthelmintic, antibacterial, astringent, digestive and for so many other traditional use, we used this research to scientifically verify Parkinson behaviour using suitable animal models. In mice, using haloperidol (1 mg/kg i.p) catalepsy was induced. Bromocriptine (2.5 mg/kg) and HECD were administered orally to the treatment group at the dose of 100 mg/kg, 200 mg/kg, and 300 mg/kg. Bar tests for catalepsy, motor coordination tests by rotarod, and locomotor activity by actophotometer were performed to evaluate behavioural changes. Dopamine and catalase assay were also carried out to assess biochemical parameters. Using standard as ascorbic acid in UV visible spectrophotometer, evaluation of antioxidant activity by DPPH radical scavenging method were performed. The outcome of our work...
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Posted by admin on Sep 30, 2021 in |
The recommended doses of antacids by some manufacturers are in ranges. However, dosing decisions on antacids should be based on acid-neutralizing capacities (ANCs). This study evaluated the ANCs of different doses of antacids. Twenty-two antacids (3 granular, 5 tablet and 14 suspension formulations) were evaluated for their ANCs at half, minimum, and double their recommended adult doses. All the products complied with the minimum ANC recommendation (5 mEq/dose), although ANCs were significantly different from each other (p < 0.0001). The ANC range for minimum recommended doses for all products was 12.417−38.817 mEq. There were no significant differences in ANCs (p = 0.1662) based on dosage form. A dose-dependent effect was observed when minimum recommended doses were halved or doubled, with significant differences in ANCs at each dose level (p < 0.0001). The ANC range for doubled doses was 19.817-71.133 mEq. The ANCs at half-doses (7.583−20.417 mEq) were also compliant with the regulatory requirement. The findings show that doses smaller than recommended amounts could be indicated for mild hyperacidity conditions,...
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Posted by admin on Sep 30, 2021 in |
To evaluate the antibacterial activity, pharmacokinetics and molecular interaction of the compounds from Ricinus communis` leaf extract. Antibacterial activity was assessed by using the micro-dilution method. The chemical constituents of the methanolic leaf extract were assessed by using gas chromatography-mass spectrophotometry (GC-MS). The drug-like and toxicity properties of the phytocompounds were predicted by SwissADME and ADMET lab tools. AutoDock Vina was employed to investigate the binding strength of the ligand-receptor complexes. The extract displayed antibacterial activity with the lowest minimum inhibitory concentration of 1.56 mg/mL on Bacillus spizizenii (ATCC 6633). The GC-MS showed volatile compounds, namely hexadecanoic acid, methyl ester (0.62%), tridecanoic acid (0.76%), pentafluoro propionic acid, nonyl ester (0.85%), 10-octadecanoic acid, methyl ester (2.93%) and cis-vaccenic acid (94.84%). The compounds did not inhibit isomers of cytochrome P450 (CPY) (CYP 2D6 and CYP 3A4). They were all predicted to have drug-like properties as they adhered to the Lipinski Ro5. The compounds did not show to induce any hepatotoxic effects. The compounds revealed the docking scores in the range of...
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Posted by admin on Sep 30, 2021 in |
DNA damage induced by Nickel chloride in lymphocytes has been studied in-vitro. The sister chromatids exchange and single-cell gel electrophoresis (SCGE), or comet assay were used to measure the level of DNA damage in terms of SCE frequency and comet parameters. Silymarin is a natural protective compound, isolated from Silybum marianum seeds and reported for its anti-genotoxic properties. In this study, the peripheral blood lymphocytes were administrated along with silymarin and Nickel chloride (NiCl2) to evaluate the antigenotoxic effect of silymarin against NiCl2 mediated genotoxicity. A significant (P<0.05) increase in the tail moment and SCE frequency indicating DNA damage was observed in NiCl2 (129.59 µg/mL) treated samples. Simultaneously, a gradual decrease was observed in the tail moment, and SCE frequency in silymarin-treated samples against NiCl2 induced DNA damage. Results showed that silymarin at a concentration of 40 µg/mL against NiCl2 induced DNA damage showed a significant (P< 0.05) decrease in...
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Posted by admin on Sep 30, 2021 in |
Background: During recent years, there has been a large investigation on different classes of thiadiazole compounds, many of which were found to possess an extensive spectrum of pharmacological activities. This study was undertaken to synthesize and evaluate the analgesic activity of [1,3,4]-thiadiazole-[1,3-dione]-isoindole derivatives. Methods: The purity of the synthesized compounds was checked by performing thin layer chromatography and determining melting points. All the synthesized compounds were subjected to spectral analysis such as FT-IR and UV-visible spectroscopy. The acute toxicity study was performed using the ‘up and down method’ while the in-vivo analgesic activity was evaluated using ‘Eddy’s hot plate method in mice, taking ibuprofen as standard. Data analysis was done using one-way ANOVA followed by Dunnett’s t-test. Results: The melting point values of each of the synthesized compounds were found to be between 145-238°C, and the molecular weight values were found to be between 204-496 gm. Spectral analysis of all the synthesized compounds has shown satisfactory results. Rf values of all the synthesized compounds were found to be different...
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