Posted by admin on Jul 31, 2021 in |
Niosomes are vesicular carriers in the drug delivery system that are reported in the seventies. They are formed by self -assembly of non –ionic surfactant and cholesterol upon hydration with aqueous media resulting in lamellar structures that encapsulates both polar and non polar drugs. In the present research work, Montelukast sodium niosomes were prepared by using non –ionic surfactant span 60 and cholesterol in 1:1 concentration by thin-film hydration method using a rotary vacuum evaporator. The prepared Montelukast sodium niosomes were incorporated into the nanogel prepared by varying concentration of carbopol 934 to check the effect of polymer concentration on gel property. Niosomal gels were optimized and evaluated for various parameters such as homogeneity, grittiness, pH, viscosity, spreadability, extrudability drug content, skin irritation, in-vitro diffusion, zeta size, zeta potential, Etem study for vesicle size and stability study. Nanogel was successfully formulated by using Montelukast sodium niosome dispersion. The average sizes of niosome vesicles were found to be 496.2 nm, and polydispersity index (PI) was found to be 0.680, zeta...
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Posted by admin on Jul 31, 2021 in |
Support of the useful medicinal properties of different native plants has gained huge significance as they can be used as a substitute source of lead compounds in pharmacological industries to begin many modern-day problems such as drug resistance in microorganisms and non-specificity in chemotherapeutic agents. Amischophacelus axillaris is one such plant that has been widely used for medical purposes in traditional systems of medicine. Hence this work seeks to validate the anticancer property of ethyl acetate extract of the plant against the A549 cell line. Anticancer activity was studied using MTT assay, which showed that the isolated compound has IC50 values lower than that standard Doxorubicin. At 50µg/mL concentration there is a lesser values, i.e., 10.47%. The results clearly revealed that the isolated pure compound from crude ethyl acetate extract from column chromatography of Amischophacelus axillaris was more potent on the A549 cell...
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Posted by admin on Jul 31, 2021 in |
Background: Scorpionism is an endemic and highly prevalent public health predicament causing severe cardio or neurotoxic effect. Ayurveda proposes a range of medicinal preparations (internal & external) in the management of Vrishchika Damsha (Scorpion sting). Among them, Hingwadi and Jeerakadi lepa are topical anti-inflammatory medications, and Bilwadi Gutika is a potent vishahara medicine (Alexeterics). Aims: To evaluate the comparative effect of Hingwadi Lepa against Jeerakadi Lepa with Bilwadi Gutika pana in the management of manda vrishchika damsha (mild scorpion sting). Methods: The present study adopted an open labelled two armed clinical trial of before and after the pilot study. It was conducted at a tertiary Ayurveda center with 30 subjects satisfying inclusion and diagnostic criteria. They were selected by convenience sampling method and divided randomly into two groups. Group I received Hingwadi lepa, and Group II was given Jeerakadi Lepa twice daily & Bilwadi Gutika pana (1gm) t.i.d. was administered orally in both groups for 7 days. Standard scoring of cardinal symptoms was used to measure the efficacy of...
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Posted by admin on Jul 31, 2021 in |
A series of 3,6-bis (3/-substituted propoxy) and 3,6-bis (5/-substituted pentyloxy) xanthone derivatives was synthesized by the condensation of 3,6-bis (3/– bromopropoxy) and 3,6-bis (5/–bromopentyloxy) xanthones with primary or secondary amines. These compounds were characterized by FT-IR, 1H NMR, and Mass spectral data. The anti-inflammatory study of the synthesized compounds was carried out using the carrageenan-induced rat paw edema method on Albino rats of Wistar strains. Thirty minutes after injection of 1% carrageenan solution into the sub plantar surface of the left hind paw, synthesized drugs were orally administered at a dose of 100 &200 mg/kg body weight. The compounds S3, S17, and S20 at a dose of 200 mg/kg body weight showed 63.32%,62.75%, and 60.71% paw edema reduction respectively after 6 hours as compared to standard diclofenac (10mg/kg) body weight which showed 68.27% reduction of paw edema after 6 hours. The molecular docking studies were also carried out in the active site of COX-2 enzymes (PDB ID: 1CX2) using Discovery studio version 2.5. The in-silico ligand binding interactions of...
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Posted by admin on Jul 31, 2021 in |
The current work comprises the assessment of antidiabetic activity of chloroform, ethyl acetate, and ethanol fractions and isolation of some phytoconstituents from chloroform fraction obtained from ethanolic extract of Echinochloa colona. The antidiabetic activity was performed using streptozocin induced diabetic model in male Wistar rats (150-200 g). The best restraint results were for metformin, chloroform, ethyl acetate and ethanol fraction was 5.85 ± 0.004 (90.08%), 6.65 ± 0.004 (67.36%), 6.96 ± 0.003 (60.14%) and 7.05 ± 0.004 (58.01%) respectively, comparing controlled diabetic rats which showed a significant reduction of blood glucose level. On total cholesterol level metformin, chloroform, ethyl acetate and ethanol fraction showed decrease in total cholesterol level by 12.16 ± 0.0044 (56.98%), 13.02 ± 0.004 (53.94%), 14.17 ± 0.004 (49.87%) and 16.37 ± 0.004 (42.24%) respectively. Significantly triglyceride was decreased by 10.39 ± 0.0044 (46.49%), 13.16 ± 0.004 (32.23%), 14.06 ± 0.004 (27.60%) and 14.56 ± 0.004 (42.24%) for metformin, chloroform, ethyl acetate and ethanol fraction respectively. Three important phytoconstituents were isolated from chloroform fraction, and structures...
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