Posted by admin on Apr 30, 2025 in |
In Latin America, Chagas is one of the most prevalent diseases, and current chemotherapy with benznidazole and nifurtimox is ineffective in chronic phase. Therefore, the development of new drugs, especially for the chronic stage of the infection, is urgently needed. Performing an in-vitro anti-trypanosome assay, we analyzed 114 plant species from Salvadoran flora, resulting in 34 active plants against epimastigote of Trypanosoma cruzi belonging mainly to the botanical families Piperaceae, Asteraceae, Salicaceae, Annonaceae, and Acanthaceae. Thus, nine of them showed prominent activity between 91.18 to 98.94% of viability suppression at 100 µg/mL (Annona holosericea, Calea urticifolia, Eremosis leiocarpa, Peperomia pseudoalpina, Piper amalago, Piper martensianum, Casearia corymbosa, Piparea dentata and Solanum nudum), highlighting C. corymbosa, P. pseudoalpina and P. martensianum as the most promising species as sources of natural compounds useful for the treatment of Chagas disease. P. speudoalpina and P. martensianum do not have reports of their phytochemical composition or biological...
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Posted by admin on Apr 30, 2025 in |
Diabetic mellitus, a prevalent metabolic disorder characterized by chronic hyperglycaemia, poses significant health challenges globally. This study focused on optimizing growth parameters to enhance the anti-diabetic activity of Penicillium sp 8, isolated from paddy soil. Initial screening of different media revealed that Potato Dextrose Broth (PDB) exhibited the highest anti-diabetic activity. Subsequent optimization involved determining the optimal inoculum concentration, temperature, and pH for maximum anti-diabetic metabolite production using PDB. The fungus demonstrated the highest activity at pH 3.5 and 30°C, with decreased activity observed under more alkaline conditions or higher temperatures. Mass cultivation in optimized conditions led to the production of significant quantities of anti-diabetic metabolites, primarily extracted from the fungal mat using successive solvent extraction. Ethyl acetate extract of the fungal mat exhibited the highest anti-diabetic activity, characterized by phytochemical tests revealing the presence of phenols, flavonoids, alkaloids, terpenoids, and carbohydrates. Chemical analysis confirmed the presence of bioactive compounds responsible for the observed anti-diabetic...
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Posted by admin on Apr 30, 2025 in |
In the present era, plant derived green products are gaining a lot of importance due to their ecofriendly nature, unique chemical compositions and mode of action. In the present study, three varieties of Moringa oleifera, namely Shyama- black color variety (most found), Shveta – white color variety and Rakta – red color variety (less found) were used for the synthesis of biosurfactant, pectins and resins. The results of the study indicated that the varieties were good sources of pectin, showing that the samples could be efficiently used in many food processing industries as a gel forming, thickening agent and as a stabilizer. Natural resins were synthesized from the varieties of Moringa oleifera leaves. The results obtained from the present study showed that Moringa oleifera could be a potential source of plant derived resins with application in medicine and pharmacy as many plant resins have been observed to elicit pharmacological effects. Biosurfactants were obtained from the leaves of the plant samples thus proving to be suitable for the formulation of green products...
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Posted by admin on Apr 30, 2025 in |
Background: The emergence and spread of Vancomycin, Linezolid and combined linezolid/vancomycin resistance in Enterococcus species (LVRE) is a major therapeutic challenge. Vancomycin-resistant Enterococci are an important cause of healthcare-associated infections. Linezolid and Teicoplanin are currently approved for the treatment of VRE; however, resistance to these antimicrobials appears to be increasing. Aims/Objectives: The study was done to find the prevalence and to study the antimicrobial resistance pattern of Enterococci isolated from patients with bacteremia in a tertiary care hospital in Ahmedabad. Methodology: This retrospective study was conducted for a period of one year; Blood samples were received and incubated in Bact/Alert 3D automated blood culture machine. Positive indicated blood samples were cultured, and identification and antimicrobial susceptibility testing was done using both manual and automated methods. Results: In this study, 4147(35%) blood samples were found positive. Out of 4147 positive blood samples 278(6.7%) samples were shown growth with Enterococci species. Out of 278 Enterococci, 8(2.87%) Enterococci were found to have both linezolid and vancomycin resistance. Conclusions: Prevalence of LVRE is low...
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Posted by admin on Apr 30, 2025 in |
This study investigated the efficacy and safety of three herbal decoctions for managing Polycystic Ovary Syndrome (PCOS), a condition affecting 2–26% of women globally and considered incurable within allopathic medicine and offers symptomatic treatments. This randomized, single-blind clinical trial, conducted between February 2022 and June 2024, enrolled 90 PCOS patients diagnosed by the Rotterdam (2003) criteria. Participants were randomly allocated into three intervention groups: Nigella sativa (Arm I), Sesamum indicum (Arm II), and a combination of both (Arm III). Each group received 30 ml of the assigned decoction twice daily over three months. Clinical parameters were assessed using established grading scales, including androgenic alopecia, hirsutism, acne, and acanthosis nigricans. Additionally, ultrasound scans (USS) were performed pre- and post-treatment to evaluate changes in ovarian morphology. Results indicated a significant reduction in ovarian volume for Arms I (P=0.029) and II (P=0.008) and an increase in follicle size across all three arms. The number of participants with polycystic ovarian morphology significantly decreased in Arm I (P=0.016) and II (P=0.004). However, one-way ANOVA...
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