Posted by admin on Jan 31, 2025 in |
Sulfadiazine belongs to a class of sulphonamide antibiotics. Sulfadiazine is a synthetic bacteriostatic sulphonamide that exhibits a broad spectrum of activity against gram-positive and gram-negative pathogens. The Sulfadiazine antibiotic is a member of the Sulfa drugs class. This drug is utilized for bacterial infections in the brain, ears, and urinary tract. The primary goal of the research is to develop and validate Sulfadiazine by Reverse Phase (RP) HPLC. An HPLC (Alliance, Water 2695) with a PDA detector and Avantor -ACE C18 250 mm × 4.6 mm × 5 µm column (Part Number ACE 121-2546) was used. A novel technique for the simultaneous measurement of sulfadiazine using the RP-HPLC technology was developed. The ACE C18 column (250×4.6 mm) 5µm successfully created the chromatographic conditions needed to separate sulfadiazine. The flow rate was 1 mL/min, and the mobile phase ratio of ACN: H2O was 70:30 v/v. 254 nm was the detection...
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Posted by admin on Jan 31, 2025 in |
Background: Residual cardiovascular risk persists despite optimal LDL-C lowering, suggesting that remnant cholesterol (RC) may contribute to atherosclerosis. Objective: To evaluate the association between RC, lipid profile discordance, and cIMT, and determine if RC and lipid discordance are independent predictors of increased cIMT after adjusting for traditional cardiovascular risk factors. Methods: In this cross-sectional study of 60 patients (mean age 56 ± 10 years, 63% male) with cardiovascular conditions, cIMT measurements and lipid profiles were obtained. RC was calculated as total cholesterol minus LDL-C minus HDL-C. Patients were grouped into four categories based on median LDL-C and RC levels. Statistical analyses assessed associations between RC, lipid discordance, cIMT, and cardiovascular risk factors. Results: RC showed a moderate positive correlation with cubed mean cIMT (r = 0.36, p = 0.0047). Patients with high discordant RC had significantly higher cubed mean cIMT compared to those with low concordant levels. In regression analysis, body mass index (β = 0.337, p < 0.001), smoking status (β = 0.819, p = 0.002), and LDL-C (β = 0.010, p = 0.044) were significant predictors of cubed cIMT, while RC showed a trend toward...
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Posted by admin on Jan 31, 2025 in |
Introduction: Abnormal uterine bleeding (AUB) is a common gynecological concern that presents significant diagnostic challenges, particularly because it encompasses a wide range of possible underlying causes, from benign conditions like polyps and fibroids to more serious pathologies such as endometrial cancer. This study aimed to assess the diagnostic accuracy of hysteroscopy in AUB and its concordance with histopathological findings. Materials and Methods: Fifty consecutive women, aged 30-70 years, with AUB were prospectively enrolled. Each underwent hysteroscopy followed by dilatation and curettage (D&C). Clinical data, hysteroscopic findings, and histopathological analysis of endometrial samples were systematically recorded and analyzed. Results: The average age of participants was 43.8 years, with endometrial polyps being the most common abnormality detected on hysteroscopy, accounting for 30% of cases. Hysteroscopy demonstrated 100% sensitivity and 92% specificity. Histopathology, however, missed 10% of polyps and 4% of hyperplasia cases. Mild anemia was present in 66% of patients, indicating potential blood loss due to AUB. Conclusion: Hysteroscopy showed a high diagnostic yield for structural causes of AUB, particularly in...
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Posted by admin on Jan 31, 2025 in |
Siddha science is an ancient way of healing which uses plants, minerals and metals for medicinal preparation. Research on herbs is gaining significant interest for discovering new drug molecules. In this context, it is essential to investigate the numerous traditional formulations documented in classical Siddha literature. The Thurinji manapagu contains Citrus medica and Saccharum officinarum is a traditional herbal syrup formulation which is indicated for nausea and vomiting, hypertension in clinical practice of siddha. The phytochemical analysis and free radical scavenging effect of the Thurinji manapagu was studied in this paper to explore the antioxidative efficacy of the drug. The qualitative phytochemicals of Thurinji manapagu was determined by standard protocols. The scavenging effect against the free radicals of the drug Thurinji manapagu was measured by the following in-vitro methods: DPPH radical scavenging assay, H2O2, ABTS, NO scavenging assay and studied through U.V spectrophotometer. The phytochemical screening of drug reveals the presence of phenols, tannins, saponins, coumarins etc. The results of the antioxidative capacity of the drug on all four...
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Posted by admin on Jan 31, 2025 in |
Allergic conjunctivitis (AC) is a prevalent ocular condition characterized by inflammation of the conjunctiva due to allergen exposure, resulting in itching, redness, and discomfort. Traditional medicinal plants such as Ginkgo biloba and Aegle marmelos have been recognized for their potential anti-inflammatory and anti-allergic properties. In this study, we conducted an in-silico analysis to explore the therapeutic potential of phytochemicals derived from Ginkgo biloba and Aegle marmelos against AC. First, we compiled a list of phytochemicals in Ginkgo biloba and Aegle marmelos, focusing on compounds known for their anti-inflammatory and immunomodulatory activities. Molecular docking studies were performed to investigate the binding interactions between these phytochemicals and key proteins implicated in the pathogenesis of AC, including histamine receptors, inflammatory cytokines, and enzymes involved in the allergic response. Virtual screening techniques were employed to identify potential lead compounds with high binding affinities and favorable pharmacokinetic properties. Additionally, ADME/T properties were predicted to assess the bioavailability, metabolic stability, and potential toxicity of the selected phytochemicals. In-silico findings suggest that certain phytochemicals from Ginkgo...
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