Posted by admin on Dec 31, 2021 in |
Background: Beta-glucogallin (BGG) is a tannin precursor naturally found in a variety of plants such as gooseberry, raspberry, amla, etc. BGG was reported to be a potential therapeutic agent in managing a variety of diseases. This investigation was intended to assess whether BGG alleviates amnesia induced by scopolamine in mice. We also investigated possible mechanisms associated with the cholinergic system and antioxidant effects. Materials and Methods: Two doses of BGG (5 & 10 mg/kg) were tested in the exteroceptive and interoceptive amnesia model: Morris Water Maze test, Elevated plus-maze model, scopolamine-induced amnesia and assessment of motor coordination activity. The assessment of in vitro antioxidant activity by DPPH method and molecular docking analysis was also performed. Results: Pre-treatment with BGG at doses 5 and 10 mg/kg have shown significant anti-amnesia activity in the behavioral models in a dose-dependent manner.BGG at a lower dose did not impact the motor coordination activity of mice; however, at a higher dose, the results did not show a major impact, though the results look statistically...
Read More
Posted by admin on Dec 31, 2021 in |
A new series of Schiff’s base compounds were synthesized by condensation of 1-(4-amino-4 phenyl) 3-phenyl triazene-1-ol) and substituted aldehyde and gave high yields of target compounds. Antimicrobial activity of compounds has been tested against bacterial and fungal species, namely gram-positive bacteria as S. aureus and S. pyogenes, gram-negative bacteria as E. coli and P. aeruginosa, and fungal species C. albicans and A. clavatus are selected based on their clinical and pharmacological importance. Bacterial and fungal tests were performed under the same conditions using Cefixime and Griseofulvin as standard drugs. It has been found that synthesized Schiff’s base has shown efficient antibacterial and anti-fungal activities. Thus they can be revealed as potent antimicrobial compounds. They are widely used for industrial purposes and also exhibit a broad range of biological activities. The structures of synthesized compounds were confirmed by TLC, melting point, Infrared spectroscopy, and proton nuclear magnetic resonance spectroscopy (1HNMR)...
Read More
Posted by admin on Dec 31, 2021 in |
Positron emission tomography (PET) imaging has been broadly used in the study of brain damage for a long time. However, PET has been mostly used for the assessment and detection of neural activity after brain damage. Tau proteins play a significant role in a variety of degenerative neurological conditions. Post-mortem neuropathology studies of victims of repeated and severe head trauma have defined a unique spatial expression of neurological tauopathies in these individuals known as chronic traumatic encephalopathy (CTE). The current review assesses the role of tau in head injury, the state of tau radiotracer development, and the potential clinical value of tau-PET derived from head injury studies. There are variations in the binding patterns between different tau radiotracers. Therefore, the present work is commenced with a general review of TBI and CTE, followed by the chronic and acute pathophysiological consequences of TBI. In the following, beta-amyloid, glycolysis, and tau protein radiotracers are assessed critically, considering the most recent and available imaging studies. Considering the scientific relevance of these radiotracers...
Read More
Posted by admin on Nov 30, 2021 in |
Natural products offer great hope in the identification of bioactive compounds and their development into drugs for the treatment of various diseases. The present study aims to evaluate the antioxidant potential of Portunus pelagicus. P. pelagicus (Station-I) possessed 33.14% of inhibition, the highest DPPH activity, whereas Station II and Station III showed 31.42% and 30.85% of inhibition. Portunus pelagicus possessed 3.34% reducing ability at 1000 µg/ml concentration in the present study in station I, station II exhibited 2.62%, and station III shpwed2.55% at 1000 µg/ml concentration. The highest reducing ability was recorded at the station I, compared to stations II and III. The present study revealed that the tissue extract of Portunus pelagicus has antioxidant capacity, and it needs further characterization to improve the pharmacologically active marine natural...
Read More
Posted by admin on Nov 30, 2021 in |
A nafion plus functionalized-multiwalled carbon nanotubes modified glassy carbon electrode (f-MWCNTs/GCE) was developed for the determination of anti-depressant drug mirtazapine (MIR). The electro-chemical behavior of the molecule was investigated employing cyclic voltammetry (CV), chronocoulometry (CC), and differential pulse adsorptive stripping voltammetry (DPASV). The surface morphology of the electrodes has been studied through scanning electron microscopy (SEM). These studies revealed that the oxidation of MIR is facilitated at f-MWCNTs/GCE. After optimization of analytical conditions employing this electrode at pH 10.5 of 0.04M carbonate buffer for MIR, the peak currents were found to be linearly with different concentrations in the range of 6.72 × 10-6 M to 3.74 × 10-4 M for MIR. The detection limits were obtained of 32.45 × 10-8 M and 9.45 × 10-7 M for MIR, using DP-AAdSV. The prepared modified electrode has several advantages, such as simple in preparation method, showed high sensitivity with very low detection limits, and gave excellent reproducibility. The proposed method was also employed for the determination of MIR in pharmaceutical formulations,...
Read More
