Posted by admin on Oct 31, 2021 in |
The research aim is to develop and evaluate Centella asiatica Chloroform extract and silver-coated suture against the most common organisms that cause surgical site infections (SSI) by in-vitro methods. This prospective study is to coat the Centella asiatica (CA) extract to the suture along with the silver nitrate solution. In this study, a suture filament was formulated with Poly Lactic Glycolic Acid (PLGA) (50:50 ratio). A formulated filament was coated with Centella asiatica extract, and its property was compared with the marketed future. After minor modifications, the marketed suture was coated with Centella asiatica extract. Antibacterial efficacy of Centella asiatica extract coated suture filaments with and without silver nitrate solution were evaluated against gram-positive and gram-negative bacteria. Chloroform extract of Centella asiatica powder was effective against gram positive and negative bacteria compared to crude powder. Particle size and Zeta potential of the CA powder extract with and without silver nitrate at the end of 3 h was found to be 676.9 and 140.1nm and 0.295 1.45mv of Zeta potential,...
Read More
Posted by admin on Oct 31, 2021 in |
The increasing microorganism resistance to common antimicrobial drugs constitutes a major public health issue worldwide and particularly in Gabon. The objective of this study was to conduct an ethnobotanical survey among merchants of Peyrie market in Libreville (Gabon) to identify plants or a combination of plants used to treat malaria in traditional medicine. Information was collected by interviewing merchants of the market using a structured questionnaire. Plant samples were identified and authenticated at National Herbarium at the Institute of Pharmacopeia and Traditional Medicine in Libreville, Gabon. A literature review of the collected species was done. Twenty-nine (29) plants were identified, and some of them are often used in combination. Decoction, maceration, and herbal teas were the different methods of preparation. Barks, leaves, and fruits were the most plant parts used. Overall, some of these plants have already been investigated for their antimalarial properties, such as Momordica foetida (Cucurbitaceae) and Enantia chlorantha (Annonaceae). The data also highlighted several chemical compounds in the plants which can be responsible for the antiplasmodial activity described,...
Read More
Posted by admin on Oct 31, 2021 in |
Bombax ceiba L. is an important medicinal plant belonging to the family Bombacaceae. Root bark samples of the plant have been subjected to phytochemical investigation through gas chromatography-mass spectrometry (GC-MS). Twenty phytochemical compounds have been identified in the methanolic extract of B. ceiba root bark. The identification of phytochemical compounds is based on the peak area, retention time, molecular weight and molecular...
Read More
Posted by admin on Sep 30, 2021 in |
This study was aimed to evaluate the anti-diabetic activity of Ethanolic extract of the whole plant administered at different dosages (100 mg/kg and 200 mg/kg) for 21 days in Dithizone-induced diabetic rats using Glibenclamide as a standard drug (hypoglycemic drug). For the study, rats were divided into five groups of six animals each. Group, I served as control, Group II served as diabetic control received Dithizone, Group III diabetic rats were served with Glibenclamide while Group IV and V diabetic rats were received 100 mg/kg and 200 mg/kg of Ethanolic extract of Caralluma adscendens whole plant. The antidiabetic potential of the whole plant extract was undertaken in Dithizone induced hyperglycemic models by comparing biochemical parameters like blood glucose levels, OGTT and lipid profile (total cholesterol, triglycerides, LDL, and HDL), total protein and liver function tests (Total bilirubin, ASP, ALT, and AST) along with the liver antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), malondialdehyde (MDA), glycogen content and Glycogenic enzymes were quantified using standard experimental procedures. ...
Read More
Posted by admin on Sep 30, 2021 in |
The main goal of this work is to formulate nanosponges and access its suitability to deliver Luliconazole for topical application, to improve its therapeutic effect, better dispersion and good storage. Nanosponges are water-soluble, which does not mean that molecules are chemically decomposed in water but that nanosponge particles are mixed with water and used as a carrier fluid. Compared with traditional drug delivery methods, nanosponges have several advantages. Using polyvinyl alcohol as a surfactant, a nanosponge with ethyl cellulose as a polymer was prepared by the emulsion solvent diffusion method. An optimized batch of nanosponges with high entrapment efficiency was used to formulate the gel with Carbopol 940. The prepared gel was evaluated for pH value, viscosity, spreadability, in vitro diffusion study, skin irritation test and in-vitro antifungal activity. The nanosponge system is non-toxic, non-irritating, non-allergenic, and non-mutagenic. Nanosponge gel as a local drug delivery system has a huge potential, with better antifungal activity and stability. These small sponges loaded with luliconazole proved to be better scaffold for topical...
Read More
