Posted by admin on Sep 30, 2021 in |
Natural phenolic acids alkyl esters viz methyl, ethyl, propyl was synthesized and characterized by spectral means FTIR, 1HNMR, and 13CNMR. All the synthesized esters were examined for their antimicrobial potential, preservative efficacy and antioxidant potential. Among the synthesized ester derivative caffeic acid and gallic acid, derivatives were displayed excellent antioxidant and antimicrobial potential. They were further evaluated their preservative efficacy according to USP 2004 protocol for preservative effectiveness testing. Caffeic acid propyl ester and gallic acid ethyl ester exhibited promising preservative potential better than existing preservative agents. From the study, we can conclude that these caffeic and gallic acid derivatives can be used as lead compounds to further explore their application as preservative agents in pharmaceuticals and in the food...
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Posted by admin on Sep 30, 2021 in |
Many herbs/phytochemicals are proved to have anti-diabetic properties and patients in the treatment of diabetes increased their usage. Administration of herbs and allopathic drugs has a chance of interaction between them, leading to alterations in pharmacokinetics and pharmacodynamics of the drug. The present study was aimed to know the influence of phytoconstituent (Allicin) on the pharmacokinetic and pharmacodynamic parameters of the drug. Pioglitazone is a thiazolidinedione class of oral anti-diabetic drug which was metabolized by CYP enzymes. The combination of piglitazone with allicin, increases the AUC in normal and diabetic rats. The pharmacodynamic parameter like blood glucose levels of diabetic rats was decreased due to the increase in the bioavailability of the drug. Allicin shows inhibitory action on CYP enzymes and decreases the metabolism of pioglitazone. However, the combination of pioglitazone with allicin alters the metabolism of the drug in diabetic rats and doses of herb-drug were monitored...
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Posted by admin on Sep 30, 2021 in |
This study assessed the biological properties and safety profile of extracts from locally grown banana leaves in Arusha (Tanzania), to affirm their possible use for wound dressing. Screening for phytoconstituents in extracts from studied banana plant species, ijuhi inkundu (IJ) mlelembo (ML) and kimalindi (KIM), revealed the presence of various secondary metabolites; anthraquinones, alkaloids, flavonoids, tannins, terpenoids, phenols, phytosterol and saponins. Susceptibility of microorganisms to studied banana varieties were in the order of KIM > ML > IJ. One-way analysis of variance (ANOVA) revealed a statistical difference of mean among all extracts (p < 0.05). Antioxidant activity was evaluated by measuring the ability of extracts to scavenge DPPH free radicals. Scavenging of DPPH was in the order of > kimalindi > ijuhi inkundu > mlelembo. Brine shrimp results for toxicity showed that almost all extracts were non-toxic to the shrimps, exhibiting mild toxicity by giving the LC50 values higher than 100...
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Posted by admin on Sep 30, 2021 in |
To evaluate the antibacterial activity of methanolic extract of Terminalia chebula, commonly called Haritaki was tested against respiratory tract infection-causing bacteria. The antibacterial activities were assessed by agar well diffusion, broth dilution and time-kill methods. It showed the best antibacterial activity against Klebsiella pneumoniae among the tested respiratory infection-causing bacteria (Streptococcus pneumonia and Streptococcus pyogenes) in the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC), at 100 mg/ml, respectively. Killing ability depends on the time and concentration of the extract, which was found optimum at 20 h at 100 mg/ml. The cell viability and cytotoxicity of the extract were tested on swine Lung Cell lines with different concentrations (100-500 mg/ml). The viability of the cells was more at 100 mg/ml, whereas the viability gradually decreases by increasing the concentration was determined by 3-[4, 5-dimethyl-2-thiazolyl]-2, 5-diphenyl-2H-tetrazolium bromide (MTT) assay. The extract showed minimal hemolytic effect in human red blood cells in Biocompatibility assay at 100 mg/ml, which was tested against standard drug levo flaxacin. It suggests that the methanolic...
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Posted by admin on Sep 30, 2021 in |
Diabetes mellitus is a metabolic condition characterized by insulin resistance, or poor secretion, or both. There are several side effects associated with drugs available to cure diabetes. The most common side effect is neurodegenerative. The objective of the present research was to evaluate the efficacy of Cuminum cyminum seed against diabetes and also to evaluate its nephroprotective power in the diabetes mice model. Twelve mice were housed, caged, and segregated into three groups for 28 days (four weeks). Control, diabetic control, and diabetic with Cuminium seed treatment. The diabetic mice model was prepared by a single dose of alloxan (110 mg/kg/bw) introduced intraperitoneally. Glucose monitoring and diabetic condition checked and confirmed by a one-touch glucometer. Alcoholic extract of Cuminum cyminium seed (80mg/kg/ body weight) orally administrated to the diabetic group of mice up to 28 days. After the completion of the whole experiment, animals were sacrificed blood samples were collected for the investigation of biochemical parameters, including glucose, urea, uric acid, and creatinine. There were the least changes observed...
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