Posted by admin on Sep 30, 2021 in |
Moringa Cocanensis Nimmo is one of the important medicinal plants belonging to the family moringaceae. Moringa Cocanensis Nimmo has antipyretic, antihelmintic, antimicrobial, hepatoprotective, and anticancer activities. It is one of the most noted systems of medicine in the world. Ayurveda is based on the hypothesis that everything in the universe is composed of five basic elements viz. space, air, energy, liquid, and soil. The traditional system was proved to be more effective when compared to synthetic drugs due to reduction in side effects, adverse effects, and even a little increase in dose was not that dangerous when compared to the synthetic drugs. It was even found to be more economical and safer in all means. Hence, we have choosed the plant Moringa Concanensis Nimmo, evaluated its medicinal property and proved its antioxidant nature for replacing synthetic drug formulations. When ringer solution containing H2O2 perfused to heart preparation, the muscaranic actions of acetylcholine were not observed much, indicating the oxidative stress on frog heart induced by H2O2; this might be...
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Posted by admin on Sep 30, 2021 in |
Traditionally Psidum guajava has been used for the treatment of several kinds of disorders. The component quercetin a flavonoid that is present in the guava leaves, is responsible of having wound healing properties, so the aim and objective of the study was to Develop Herbal loaded Niosomes for the treatment of Wound Healing. To enhance the transport and efficacy of many materials through stratum corneum one of various methods expanded nowadays is the usage of new drug delivery system such as Niosomal formulations. Niosomes are self assemblies of non ionic surfactants with or without cholesterol, which can be used for both hydrophilic and hydrophobic substances. The extraction of Psidum guajava is performed by Soxhlet apparatus, and the extract is evaluated for phytochemical screening, antimicrobial activity, and TLC. Materials used in the formulation are span 60, cholesterol, diethyl ether, chloroform, buffer and extract. The herbal drug-loaded niosomes are prepared by using reverse phase evaporation method. Total twelve formulations are prepared and the formulations (F1, F2, F3, F4, F5, F6) were...
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Posted by admin on Sep 30, 2021 in |
A selective and high throughput RP-HPLC method was developed to detect and quantify Famotidine in rat plasma using Ranitidine hydrochloride as an internal standard (IS). After liquid-liquid extraction, the analyte and the internal standard were chromatographed on Enable 18H (5µ, 250×4.6mm) C18 column using 20 µL injection volume with a run time of 15 minutes. An isocratic mobile phase consisting of phosphate buffer pH 6.8 and methanol (50:50 %v/v) was used to separate drug and internal standard. The method was validated according to USFDA guidelines over the range of 50-1200 ng/mL. The absolute recovery for analyte achieved from spiked plasma sample was consistent and reproducible. Precision and accuracy (%CV) across four validation runs (LLOQ, LQC, MQC and HQC) was less than 15. LLOQ was found to be 50 ng/mL. The validated RP-HPLC method was used successfully to study Famotidine SNEDDS pharmacokinetics in rats and also quantitative determination in Solid Self Nano Emulsifying Drug Delivery System...
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Posted by admin on Sep 30, 2021 in |
Sustained released dosage form having an advantage over immediately release drug delivery system by continuous release of medicaments for a specific period in a prolonged manner. Diabetes mellitus (DM) is a common test endocrine issue that influences in excess of 100 million individuals ls around the world. Type II diabetes is characterized by peripheral insulin resistance and impaired insulin secretion. Metform in hydrochloride (Met) used in the treatment of type 2 diabetes, having a short half-life is a challenge for the researcher towards achieving sustained drug delivery systems. Met with higher dose shows high solubility and inherent compressibility. Towards the same, Met was formulated with different combinations of polymers such as chitosan, HPMCK 100 M and eudragit RL-100 by the wet granulation method. The formulated granules were subjected for a pre-compression study like bulk density, tapped density, compressibility index, Hausner’ sratio and angle of repose. The formulated tablets possess for post-compression studies. Drug-polymer interactions were investigated by FTIR studies. In-vitro drug release kinetics is carried out at pH 6.8....
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Posted by admin on Sep 30, 2021 in |
The main aim of the present study is to formulate and evaluate solid lipid nanoparticles of Metoprolol. Metoprolol is an anti-hypertension drug used in the treatment of hypertension, angina pectoris, and heart failure. Metoprolol belongs to BCS class-I, which has high solubility and high permeability. The drug needs to be administered frequently (2-3 times a day), and it has side effects and poor bioavailability of 40-50% drug through oral administration. In order to avoid the side effects and to improve its bioavailability and sustained release of the drug, there is a need to develop Metoprolol-loaded solid lipid nanoparticles. In the present study, solid lipid nanoparticles of Metoprolol were prepared by the Hot Homogenization technique. In this solid lipid nanoparticles of Metoprolol, employing Compritol as the carriers and Tween 80, PEG-400 and soya lecithin as surfactant systems and were evaluated for various parameters like entrapment efficiency, drug content and in-vitro drug release, particle size and zeta potential. The C8(1:3) formulation showed better results entrapment efficiency of 98.20%, drug content of...
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