Posted by admin on Jul 31, 2021 in |
The solubility, dissolution, and gastrointestinal permeability are the prime factors for drug absorption. Rifaximin is a structural analogue of rifamycin that inhibits RNA synthesis by binding to β-subunit of bacterial DNA-dependent RNA polymerase. Rifaximin is a class 1V drug having low solubility and low permeability. My theme of the design is to develop the technological characterization of dosage by converting the drug into nanoparticles and superdisintegrant technology; the drug undergoes solubility and gastrointestinal permeability. By adopting these technologies, it achieves by enhancing the disintegration time of drug when comes in contact with water. Here I would like to promote the range of method development technologies improving the solubility and permeability of class IV drugs in...
Read More
Posted by admin on Jul 31, 2021 in |
Self-medication with OTC drugs is observed in many countries and deserves due concern as it may adversely affect maternal and fetal health. This practice may have an association with socio-demographic factors and knowledge about OTC medicine. A descriptive study was done using a questionnaire that collects information on socio-demographic status, prevalence and knowledge of OTC medicine use among pregnant women. The pregnant women visiting government hospitals in the A sir region were randomly selected. The data collected was analyzed by SPSS software version 20. Moderate level of knowledge about OTC medicine was observed in more than half the sample. More than two-third of the sample was found to have used OTC medicine during their pregnancy. High prevalence of OTC medicine use was found among the unemployed and university-educated sample groups. There was significant association between age of the mother and OTC medicine use, while the association with other socio-demographic variables was not significant. The highest prevalence of OTC medicine use was observed in the sample with a high level...
Read More
Posted by admin on Jul 31, 2021 in |
The proposed study was to evaluate the in-vitro cytotoxic and antiproliferative activities on prostate cancer cell lines of isocordoin (1) and 2’,4’-dihydroxy-3’-(g,g-dimethylallyl) dihydrochalcone (2), chalcones isolated from roots of Lonchocarpus xuul Lundel, together with four analogues of 1. Isolation of compounds 1 and 2 from L. xuul roots and chemical modification were in accordance with previous works. All compounds were characterized by NMR spectroscopy and mass spectrometry. In-vitro cytotoxic and antiproliferative activities of compounds 1-6 against prostate cancer cell lines PC3, PC3M, DU145, and TRAMPC2, were evaluated using the MTT and sulforhodamine B method, respectively. Additionally, cytotoxic studies with HEK 293 cells were carried out, and a selective index was calculated. From them 2’,4’-dihydroxy-3’-(g,g-dimethylallyl) dihydrochalcone (2), 2´,4´-diacetoxy-3´-(3-methylbut-2-enyl) chalcone (3), 2´-methoxy-3´-(3-methylbut-2-enyl) chalcone (5) together with isocordoin (1) showed the strongest cytotoxic activity on PC3M cell lines in the ranged of 2-3 mg/mL. Isocordoin showed the strongest activity also on TRAMPC2 cell lines (CC50= 1.01 mg/mL). None of the compounds were cytotoxic (CC50 =14 to 667 mg/mL) on HEK293 cell line....
Read More
Posted by admin on Jul 31, 2021 in |
Background: Urinary Tract Infections (UTIs) are one of the most commonly occurring infections in medical practice despite the widespread availability of antibiotics. This study aims to ascertain the prevalence of uropathogens and determine their antibiotic susceptibility or resistance patterns in the Indian population. Methods: A thorough search on the research studies concerning UTIs and their antibiotic susceptibility patterns in India was conducted through electronic databases including Google Scholar, Directory of Open Access Journals, Web of Science, Elsevier, etc. Search results were evaluated for the appropriateness of being included in the study. A total of 12 reports published from different regions of India were involved in the study. Analysis of data was performed using Comprehensive Meta-Analysis (CMA) software. Results: The most commonly isolated uropathogens were observed to be E. coli, and Klebsiella spp., with a prevalence of 49.6% and 12.8%, respectively. The highest mean resistance was found to be towards Ciprofloxacin, followed by Ampicillin. Resistance patterns in E.coli were found to be more towards Ampicillin (74.11%) and followed by Ciprofloxacin...
Read More
Posted by admin on Jul 31, 2021 in |
The present pharmacological examination was purely focused on the assessment of the efficacy of ethanolic extract of C. pedata var. glabra for their protection against Paracetamol overdose-induced hepatotoxicity arbitrate with their phytoconstituents and also observe whether synergistic hepato-protection exists with Silymarin. For animal studies, the Albino rats (150–200 g) were divided into six groups viz., Group I served as control, Group II served as a toxic group, Group III received Silymarin and Group IV, V and VI received plant extracts at the rate of 100, 200 and 400 mg/kg. After group segregation, on 15th day, Paracetamol was administered to groups II, III, IV, V, and VI. The results indicate that compared with Group II the Group I are significant at p<0.05. However, Group III, IV, V, VI are significant at p<0.05 when compared with Group II. Pretreatment with ethanolic extract-treated groups significantly prevented the physical, biochemical, histological, and functional changes induced by Paracetamol in the liver. The extract showed significant hepatoprotective effects as evidenced by decreased serum enzyme activities...
Read More
