Posted by admin on Jun 30, 2021 in |
Anxiety disorders are among the most prevalent and high-cost diseases. Medicinal plants are a very good option to treat, and several have shown the ability to reduce anxiety. We report here the effect of A. gratissima var. gratissima (Agg) on behavior and anxiety in mice. The methanol extract of leaves was tested in order to verify the safety, effect on sleeping time and behavior. Anxiety was tested through the Open field, Hole board, and elevated plus maze tests, with 50, 100, 200, and 400 mg/kg of Agg, and diazepam as positive control drugs. The results showed that A. gratissima var. gratissima did not cause signs of toxicity or sedative effect, and the general behavior of mice was not altered with any dose. All doses of Agg and diazepam, after the mice were submitted to the Open field and Hole board, evidenced a significant increase in ambulation, and a significant decrease in immobility time, related to the control group. On Hole board, a significant increase in number and time spent...
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Posted by admin on Jun 30, 2021 in |
The objective of research work is to formulate a venlafaxine HCl containing medicated chewing gum that has greater bioavailability and compliances than conventional treatment strategies. The four different formulations were prepared after some trial batches, containing different concentrations of the gum base and sucrose (MCG- I- MCG- IV). These batches were optimized on basis of softness and sweetness. Batch MCG- II was found to be optimized containing 60% gum base and 15% of sucrose. Further batches were characterized on basis of Physical characterization, texture analysis, drug content and in-vitro drug release. All batches show good color, softness, and taste. Drug content was found out in a range of 98.43- 99.24%. The in-vitro drug release data revealed that MCG- II shows better drug release than other formulations. Medicated chewing gum can be a better choice for the treatment of depression in the coming years, which may provide several benefits to patient....
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Posted by admin on Jun 30, 2021 in |
Ledipasvir and Sofosbuvir Combination have been approved for the treatment of Chronic Hepatitis C Viral Infection. Here an accurate, valid, elementary, and error-free reverse-phase liquid chromatography strategy was developed for the quantitation of Ledipasvir and Sofosbuvir in its bulk form as well as in fixed dosage form. Effective chromatographic separation of Ledipasvir and Sofosbuvir was achieved by using Kromasil C-18 (250 × 4.6 mm, 5 µm) column using Phosphate buffer (pH 3.5) and Methanol in the proportion of 45:55 v/v. The Mobile phase was siphoned at a flow rate of 1.0 mL min-1 with a column temperature of 35 ºC, and detection wavelength was carried out at 259 nm. The retention time was found to be 3.294 min for Sofosbuvir and 4.630 min for Ledipasvir. The dimensionality of Sofosbuvir and Ledipasvir was in linear range with a parametric static of 0.999 and 0.999. Method Validation was carried out in terms of Specificity, Linearity, Precision, Accuracy, LOD, LOQ as per ICH Guidelines. Results obtained from the validation studies show that...
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Posted by admin on Jun 30, 2021 in |
Background and Objectives: Acne vulgaris is a chronic skin infection affecting the majority of teenagers and adolescents. It is a disease that affects almost 80% of individuals. Acne, by definition, is multi-factorial chronic inflammatory disease of the Pilosebaceous unit. Nowadays, herbal formulations are gaining popularity in the treatment of various diseases. By considering this fact, the present study was undertaken to prove the potential of Amalaki Capsule in the treatment of Acne. Methods: 24 patients were equally divided into two groups. One group (Trial group) was given two Amalaki capsule (each containing 250mg standardized extract) twice daily after meal for 60 days, while the other 12 patients (Control group) received two capsules of maize starch powder twice a day after meal for 60 days. Results: All 24 patients completed the treatment undertaken. No drop-out was observed. Highly significant (P< 0.001) effect was observed in Skin Hydration, Acne count, and Severity score in comparison to the Control group. The trial drug (Amalaki capsule) also showed good anti-oxidant property through different...
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Posted by admin on Jun 30, 2021 in |
Background: To evaluate the various adverse drug reactions with different cancer chemotherapy regimens, severity, causality assessment and preventability. Methods: This cross-sectional, observational study was carried out in the oncology department at a tertiary care teaching hospital over a period of one year. Data on Adverse Drug Reactions (ADRs) of anticancer drugs were collected of cancer patients diagnosed by a concerned clinician from the oncology department. These ADRs were assessed for causality using Naranjo’s probability scale. The severity and preventability of the reported reactions were assessed using the modified Hartwig and Siegel scale and modified Schumock and Thornton scale, respectively. Data were analyzed using Descriptive Statistics and Microsoft Excel. Results: Out of 683 ADRs recorded from 198 patients, m/c ADRs were alopecia (21.08%), n/v (17.27%) & nail pigmentation (11.56%), etc. Taxanes, Platinum compounds, Nitrogen mustards, Antibiotics, and Antimetabolites were the most common group of drugs causing ADRs. On Causality Assessment showed highest ADRs were “possible” (49.34%), “probable” (47.58%) & few were “doubtful” (3.07%). Severity Assessment showed a majority of the...
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