Posted by admin on Jun 30, 2021 in |
A stability-indicating method by UV spectrophotometry has been developed for the specific determination of Amorolfine HCl in bulk in the presence of its degraded products. The method is simple, accurate, precise, and robust. Experiments were designed for determining linearity, the limit of detection and quantitation, accuracy, precision, and specificity of this analytical method as per the International Organization for Standardization guidelines. The drug substance was exposed to thermal, photolytic, hydrolytic, and oxidative stress conditions, and the stressed samples were analyzed using the proposed method to demonstrate the specificity of the method. The proposed method was found to be linear in the concentration ranges from 2-20µg/ml with the linear correlation coefficient of R2= 0.990, and the mean recovery was 95.59 % at a detection wavelength of 215 nm. Although the degradation products of stressed conditions had not been identified, the method had been able to detect the changes due to stress conditions. The stated method can be used as a stability-indicating method with a high degree of linearity, accuracy, and...
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Posted by admin on Jun 30, 2021 in |
Urolithiasis is a common urological disorder responsible for serious human affliction and cost to society with a high recurrence rate. The aim of the present study was to systematically evaluate the leaf extract of Citrus medica using suitable in-vitro and in-vivo models to provide scientific evidence for its antilithiatic activity. Cystone has been suggested to be beneficial in urolithiasis, as it corrects the crystalloid, colloid stability. It is evaluated that flavonoids, triterpenoids and saponins from different plants resulted in the antilithiatic activity. To explore the effect of Citrus medica on sodium oxalate crystallization, in-vitro assays like crystal nucleation and aggregation were performed. The biochemical parameters like calcium, oxalate, magnesium, phosphate, sodium, and potassium were evaluated in urine, serum, and kidney homogenates. Histopathological studies were also done to confirm the biochemical findings. In-vitro experiments with Citrus medica showed concentration-dependent inhibition of sodium oxalate nucleation and aggregation. In the in-vivo model, Citrus medica reduced both sodium and oxalate supersaturation in urine, serum, and deposition in the kidney. The biochemical results were...
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Posted by admin on Jun 30, 2021 in |
Objective: The key objective of the study is to evaluate the Anti-Alzheimer activity of methanolic extracts of buchnania Lanzan leaves by Aluminum Chloride induced Alzheimer’s. Buchanania lanzan Spreng a well-known forest plant of the family Anacardiaceae. It is reported to have numerous uses in the indigenous system of medicine in India. Material and Methods: Albino Wistar rats were administered with AlCl3 at a dose of 4.2 mg/kg/day i.p. for 4 weeks. Experimental rats were given Buchnania Lanzan Leaf extract in two different doses of 200 mg and 400 mg/kg/day orally 1hr before the AlCl3 administration for 4 weeks. Learning and memory parameters were evaluated using elevated plus maze (EPM), Radial Arm Maze, and T Maze paradigms. Results: The preliminary phytochemical investigation of Buchnania Lanzan Extract showed the presence of carbohydrates, alkaloids, flavonoids, phenols, tannins, saponins. In this study, Buchnania lanzan leaves extract was an administration for 28 days showed significant neuroprotective activity in aluminum chloride-induced rats of cognitive impairment and oxidative stress analyzed by using various behavioral Studies. Conclusion:...
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Posted by admin on Jun 30, 2021 in |
Postoperative atrial fibrillation (POAF) is a frequent rhythm disturbance after cardiac surgery and is associated with poor cardiovascular outcomes. Beta-blocker therapy is an effective strategy to prevent or decrease the high incidence of POAF and β1-adrenergic receptor (β1AR) polymorphisms that affect the cardiac response to β1AR antagonists. The study objective is to analyze the association between genetic variations in the β1AR gene and the risk of POAF and the prophylactic effect of beta-blockers. Totally, 198 patients undergoing first-time cardiac surgery were examined. The patients after operation were grouped as either with POAF or without POAF according to their continuously electrocardiogram monitoring within ICU and hospital admission period. Subsequently, genotype frequencies of the β1AR gene were determined by polymerase chain reaction-restriction fragment length polymorphism. The results showed that 63 patients (31.8%) of the total study population developed POAF. After the application of a multivariate logistic regression model, the incidence of POAF was associated with Arg389Gly genotype (OR=2.48; 95% CI, 1.06-5.76; p=0.036), Arg389Arg genotype (OR=3.38; 95% CI, 1.28-9.33; p=0.018) and Arg389Ser49...
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Posted by admin on Jun 30, 2021 in |
Fluvoxamine Maleate, an oral serotonin reuptake inhibitor, has been used widely for the treatment of anxiety. Sustained-release matrix-type drug delivery system has advantages over conventional modes of drug administration, enhancing drug bioavailability as it avoids the first-pass metabolism and improves patient compliance. Optimization of the formulation was performed by varying the concentration of natural polymer Moringa oleifera gum and HPMC K100, i.e., releases retarding polymers. Sustain release matrix tablets were formulated, and the drug release profiles of formulations F3 and F6 were found to be 93.8008% and 96.94108%,...
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