Posted by admin on Jul 31, 2021 in |
A series of 3,6-bis (3/-substituted propoxy) and 3,6-bis (5/-substituted pentyloxy) xanthone derivatives was synthesized by the condensation of 3,6-bis (3/– bromopropoxy) and 3,6-bis (5/–bromopentyloxy) xanthones with primary or secondary amines. These compounds were characterized by FT-IR, 1H NMR, and Mass spectral data. The anti-inflammatory study of the synthesized compounds was carried out using the carrageenan-induced rat paw edema method on Albino rats of Wistar strains. Thirty minutes after injection of 1% carrageenan solution into the sub plantar surface of the left hind paw, synthesized drugs were orally administered at a dose of 100 &200 mg/kg body weight. The compounds S3, S17, and S20 at a dose of 200 mg/kg body weight showed 63.32%,62.75%, and 60.71% paw edema reduction respectively after 6 hours as compared to standard diclofenac (10mg/kg) body weight which showed 68.27% reduction of paw edema after 6 hours. The molecular docking studies were also carried out in the active site of COX-2 enzymes (PDB ID: 1CX2) using Discovery studio version 2.5. The in-silico ligand binding interactions of...
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Posted by admin on Jul 31, 2021 in |
The current work comprises the assessment of antidiabetic activity of chloroform, ethyl acetate, and ethanol fractions and isolation of some phytoconstituents from chloroform fraction obtained from ethanolic extract of Echinochloa colona. The antidiabetic activity was performed using streptozocin induced diabetic model in male Wistar rats (150-200 g). The best restraint results were for metformin, chloroform, ethyl acetate and ethanol fraction was 5.85 ± 0.004 (90.08%), 6.65 ± 0.004 (67.36%), 6.96 ± 0.003 (60.14%) and 7.05 ± 0.004 (58.01%) respectively, comparing controlled diabetic rats which showed a significant reduction of blood glucose level. On total cholesterol level metformin, chloroform, ethyl acetate and ethanol fraction showed decrease in total cholesterol level by 12.16 ± 0.0044 (56.98%), 13.02 ± 0.004 (53.94%), 14.17 ± 0.004 (49.87%) and 16.37 ± 0.004 (42.24%) respectively. Significantly triglyceride was decreased by 10.39 ± 0.0044 (46.49%), 13.16 ± 0.004 (32.23%), 14.06 ± 0.004 (27.60%) and 14.56 ± 0.004 (42.24%) for metformin, chloroform, ethyl acetate and ethanol fraction respectively. Three important phytoconstituents were isolated from chloroform fraction, and structures...
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Posted by admin on Jul 31, 2021 in |
Previous studies investigated the host-derived salivary matrix metalloproteinases (MMPs) are responsible for dentin caries progression. The utilization of the MMP inhibitors can become a successful strategy to control dentin caries. In this study, we have tested twenty-four different medicinal plant leaf extracts against human salivary MMPs for investigation of inhibitors. Total phenolics were extracted in methanol, and their assessment was performed by Folin-ciocalteau assay. The presence of salivary MMP inhibitors in all plant leaf extracts was tested by using gelatin zymography. S. cumini leaf extract was found to be containing the highest total phenolics content. Leaf extracts of S. cumini, T. catappa and C. fistula exhibited strong inhibitor activity against salivary MMPs. Presence of inhibitor activity was found to be depending on the amount of phenolics concentration in extracts. The inhibition of salivary MMPs due to the binding action of phenolics with salivary proteins was concluded. As per the data of image J gel analysis software, T. catappa leaf exhibited prominent inhibitor activity as compared to other plants. The...
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Posted by admin on Jul 31, 2021 in |
Objective: To investigate the hepatoprotective activity of polyherbal formulation composed of extracts of Bauhinia variegata, Oxalis corniculata, and Pterocarpus marsupium. Methods: The hepato-protective activity of the formulation and extracts were assessed on the basis of histopathological changes in the liver and estimation of SGOT, SGPT, SALP, serum bilirubin of carbon tetrachloride-induced hepato-toxic rats. Results: The result of the present studies strongly indicates that the hepatoprotective property of polyherbal formulation is evidenced by less damaged hepatocytes cells. Conclusion: Polyherbal formulation composed of aqueous extracts of Bauhinia variegata, Oxalis corniculata, and Pterocarpus marsupium revealed significant hepatoprotective profile as compared to standard formulation...
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Posted by admin on Jul 31, 2021 in |
Introduction: The study was aimed at knowing the effect of mobile phone electromagnetic radiation (EMR) on fertility in Wistar Albino Rats and to assess the capability of polyphenolic rich Withania somnifera root extract in shielding rat testis against EMR-induced injuries. Methodology: One hundred and forty-four male Wistar Albino Rats were included in the study and grouped in to 4. Group I received a standard diet, Group II exposed to active mobile phone radiation of 2700 MHz fields for 3 hours/day, Group III exposed to 2700 MHz fields for 3 hours/day along with administration of 250 mg/kg aqueous extract of Withania somnifera root (Aq-Wsr) orally and Group IV received standard diet and 250 mg/kg Aq-Wsr during the experimental period of 180 days. Results: Group-II showed a significant decline in the sperm parameters and reduced in-vivo antioxidants. Group III revealed significant augmentation of sperm parameters and regulated the in vivo antioxidants. On microscopic examination, Group II showed irregular seminiferous tubules, atrophy of spermatogonial cells, hyper-cellularity, degenerated spermatozoa, and decreased number of...
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