Posted by admin on Jul 31, 2021 in |
Traditionally Persea schiedeana is used for headache relief, as anti-hypertensive, nervous relaxant, dermal diseases, among others. In this study, this plant from Salvadorian flora acute toxicity was evaluated in-vivo at 500 mg/kg, and the analgesic activity was tested by acetic acid, formalin, and tail flick tests in NIH Swiss mice at doses of 100, 250, and 500 mg/kg body weight, using as a positive control Indomethacin 10 mg/kg and distilled water as a control. Secondary metabolite profile was performed by Thin Layer Chromato-graphy (TLC) and ultra-efficient liquid chromatography-mass spectrometry (UPLC-MS). It was determined by TLC, the presence of terpenoids, flavonoids, tannins, lactonic groups, and coumarins, while UPLC-MS confirmed the presence of scopoletin. The biological assays demonstrated that P. schiedeana was deprived from toxic effect at the doses tested and the analgesic activity was confirmed in aqueous, ethanol, and dichloromethane extracts of Persea schiedeana leaves. Additionally, it was detected the presence of terpenoids, flavonoids, condensed tannins, lactones, and coumarins, and by UPLC-MS, the identity of coumarin as scopoletin was confirmed....
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Posted by admin on Jul 31, 2021 in |
In Ayurveda, ghrita (ghee) and taila (oil) are commonly used for treatment either internally or externally. It is commonly believed that by consumption of oil or ghee will lead to hyperlipidemia. Hyperlipidemia is an ailment of lipid metabolism produced by an increase of plasma concentration of the various lipid and lipoprotein, which cause cardiac disease, premature coronary artery disease, stroke, atherosclerosis and pancreatitis. Before the preparation of anyoushadhi siddha (medicated) taila (oil), and ghrita (ghee), murchana (processing of ghee) is a kind of samskara (procedure) mentioned in bhaishajya ratnavali. On administration of panchatikta ghrita prepared by a murchita and murchita ghrita (processed ghee) in albino rats, the results shown murchana samskara (processing of ghee) helps to reduce total cholesterol, LDL, triglycerides and increase in HDL. Guna (properties) and karma (action) of the drugs used in the panchatikta ghrita and murchana samskara (processing of ghee) might have contributed. Recent studies also show that triphala, musta (Cyperus rotandus), haridra (Curcuma longa), and matulunga (Citrus medica) are used for murchana samskara (processing...
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Posted by admin on Jul 31, 2021 in |
The study was carried out to determine the chemical, functional, and structural properties of starch that was isolated by various methods from pearl millet (Pennisetum Typhoidium). Isolation methods of starch with different chemicals influenced starch properties. Pearl millet starch was isolated by Sodium azide (alkaline) (T1), Sodium metabisulfite & lactic acid (T2) (neutral), and Mercuric chloride (acidic) (T3). Chemical and functional properties were observed. T1 yielded a higher amount of starch (56.3 /100g) (db) compared to T2 and T3. Proximate analyses of starch showed that the protein content was 0.21 – 0.31%, apparent amylose was 19.42 – 21.60%; however, similar values were observed in fat (0.01%) and ash (0.05%). The swelling power and solubility of the isolated starches differed significantly. The crystalline degree of pearl millet starch of T1 T2 T3 was 37.91, 29.22, and 19.92%, respectively. The result showed that isolation methods brought changes in yield, chemical, and functional properties of pearl millet starch. Starch isolated with alkaline had a higher amount of yield, apparent amylose, and total...
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Posted by admin on Jul 31, 2021 in |
Hypertension or elevated blood pressure (BP) is a serious medical condition that significantly increases the risks of heart, kidney, brain, and other diseases. In persons with normal BP and uncomplicated essential hypertension, BP falls to the lowest levels during the nighttime sleep, and rises suddenly with morning awakening, and reaches the peak during the initial h of diurnal activity. The optimum therapy only results when the right amount of drug is delivered to the right targeted organ at the most suitable time. The present research aimed to develop a chronotherapeutic drug delivery system of combination drugs using mini-tablets technology, which can be administered at bedtime and releases Amlodipine within 2 h followed by the rapid release of Losartan after the lag time of 6 h. The developed mini-tablets were evaluated for compatibility studies, pre-and post-compression parameters. The compatibility studies indicate no chemical reaction, pre-compression parameters indicate good flow properties, and post-compression parameters were within limits. The obtained results of in-vitro studies have shown that Amlodipine and Losartan were not...
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Posted by admin on Jul 31, 2021 in |
In this article, an attempt was made to develop molecular docking studies on active metabolites of Prasugrel, Clopidogrel, and Ticlopidine acting as protein P2Y12 inhibitors. Molecular docking analysis was performing by using autodock version 4.3 adjoin with discovery studio to better understand the interactions between P2Y12 targets and inhibitors in this series. Hydrophobic and hydrogen bond interactions lead to the identification of active binding sites of P2Y12 protein in the docked complex, signifying the affection of active Metabolite of Prasugrel is more than other active metabolites of ticlopidine and clopidrogrel. The present study may lead to the discovery of therapeutically potent agents against clinically very important cardiovascular disorders, including arterial thrombosis, Hypertension, embolism etc. cardiac diseases. Hence the computer-aided drug design docking model proposed in this work can be employed to design the metabolites of Clopidogrel, Prasugrel, and Ticlopidine with specific P2Y12 inhibitory activity and futuristic active metabolites...
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