Posted by admin on Apr 30, 2021 in |
Ibuprofen is a widely used non-selective non-steroidal anti-inflammatory drug. Ibuprofen oral use is restricted by its potential gastric toxicity, which can be overcome utilizing alternative drug delivery routes. A novel micellar transdermal delivery of Ibuprofen was readily prepared herein using the solubility enhancing co-polymeric excipient polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (Soluplus®). Ibuprofen polymeric micelle systems were prepared at a wide range of concentrations and characterized by particle size analysis, rheology measurement, infrared spectroscopy, and differential scanning calorimetry. Nanosize micelles were obtained (< 100 nm), with a small polydispersity index, at 0.5 – 2% concentration range of Soluplus®. The aqueous solubility of Ibuprofen was significantly enhanced in Soluplus®micelle system. The highest solubility was achieved at a concentration of 2% of Soluplus® with an approximate ten-fold increase in solubility. Moreover, statistical analysis of Ibuprofen’s permeation from Ibuprofen polymeric micelle systems against a control sample revealed an increase in the cumulative drug permeation with increasing polymer...
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Posted by admin on Apr 30, 2021 in |
The aim of the present study was to enhance the solubility of the poorly soluble drug Ranolazine. Solid dispersions were prepared using PVP K-30 and PEG 4000 & 6000 by melting, solvent evaporation using varying polymer ratios (1:1, 1:2, 1:3, 1:4). The prepared formulations were characterized for saturation solubility, IR, PXRD, SEM. The aqueous solubility of Ranolazine was favored by the presence of polymers. In contrast to the very slow dissolution rate of pure Ranolazine, amorphous solid dispersions considerably improved the dissolution rate. PXRD, DSC, SEM studies confirmed the amorpicity of Ranolazine. The saturation solubility of pure drug RN was found to be 0.142mg/ml, whereas that of SD4 was found to be 0.77mg/ml. The drug release of the pure drug was 28.70% at the end of 3 hours and the drug release was found to be enhanced in SD4 that is 96.44% and SD8 is 84.85%. The formulations SD4 and SD8 showed the highest solubility and dissolution rate. This can be attributed to the increased wettability and dispersibility of...
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Posted by admin on Apr 30, 2021 in |
A simple stability-indicating high-performance thin-layer chromatographic method which is economic, selective, and precise for analysis of Sofosbuvir (SFB), both as a bulk drug and in formulations, was developed and validated according to ICH guidelines. The method employed HPTLC precoated Merck TLC plates RP-18 F254 as the stationary phase while the solvent system prepared by mixing n-Hexane: Ethyl Acetate: Methanol in proportion 5:3:2 v/v. The system was found to give a compact spot for the drug (Rf value of 0.452 ± 0.004). Densitometric analysis of SFB was carried out in the absorbance mode at 261 nm. The linear regression analysis data for the calibration plots showed a good linear relationship, R2 = 0.9994, with respect to peak area in the concentration range 100-600 ng/band. The LOD and LOQ were 8.009 ng/band and 24.270 ng/band, respectively. SFB was subjected to hydrolysis, oxidation, and thermal degradation, which indicates the drug is susceptible to hydrolysis, oxidation, and heat. The method was validated for precision, recovery, and robustness. Statistical analysis proves that the method...
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Posted by admin on Apr 30, 2021 in |
Antimicrobial activity of the various species of Cymbopogon plants like Cymbopogon citrates, Cymbopogon martini, Cymbopogon nardus, Cymbopogon flexuosus, Cymbopogon schoenanthus against various pathogens like E. coli, Bacillus subtilis, Streptococcus species, Salmonella typhimurium, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumonia, Serratia marcescens were studied with the help of agar well diffusion method. The samples were extracted with solvents like Methanol, Ethanol, Chloroform, Acetone, Diethyl ether to measure the antimicrobial activity by using Muller-Hinton agar plates. The Chloroform and Diethyl ether extract of Cymbopogon flexuosus, Cymbopogon martini showed the highest zone of inhibition against Staphylococcus aureus and Pseudomonas aeruginosa. In Cymbopogon citrates, all the pathogens were resistant to all the extracts except for Streptococcus species and Pseudomonas aeruginosa, which showed the least susceptibility to all the extracts except for Methanol and Diethyl ether extract. In Cymbopogon schoenanthus, Methanol extract showed the highest zone of inhibition against Staphyloccocus aureus and Bacillus subtilis, but Klebsiella pneumonia showed resistance to all the extracts except for Diethyl ether which showed the least zone of inhibition. In...
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Posted by admin on Apr 30, 2021 in |
Cadmium can cause various health problems even at low concentrations by inducing oxidative damage in tissues of organisms. Nowadays, the focus has been raised toward the use of herbal treatment against heavy metal toxicity. Hence, the present research work was aimed to investigate the protective effect of curcumin against Cd-induced toxicity in the auricles and ventricles of the heart in albino mice. Mice were equally divided into 8 groups, with 5 mice in every group. The experiment was performed in two intervals of for 15 and 45 days. Mice were divided into the following groups: control, CdCl2 (1mg/kg bw of Cd daily), CdCl2+Curcumin (1mg/kg bw of Cd daily+100 mg/kg bw of Curcumin on alternate days), and Curcumin (100 mg/kg bw of Curcumin on alternate days) and then marked as group 1, 2, 3 and 4 for 15 days and group 5, 6, 7 and 8 for 45 days interval. Animals were sacrificed after 15 and 45 days of treatment. The biochemical analysis depicts the generation of oxidative stress with...
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