Posted by admin on Apr 30, 2021 in |
Globally, a vast number of people are affected by helminth parasites. The emergence of anthelmintic resistance has paved the way for new leads into potential anthelmintic agents, which may be alternatives to already existing ones. The mode of presentation of herbal medicines affects patient compliance. Traditionally, Cinnamomum zeylanicum is used in the management of helminth infestations. This study sought to evaluate the anthelmintic activities of the crude ethanol extracts of Cinnamomum zeylanicum to authenticate its folkloric use and formulate a dosage form of the most efficacious extract. The leaf and bark powder obtained from the ethanol extract was subjected to phytochemical screening. In-vitro experiments were conducted on Pheretima posthuma and Haemonchus contortus using various concentrations of Cinnamomum zeylanicum leaf and bark extracts. Immediate-release tablets were successfully formulated from Cinnamomum zeylanicum bark extract. The formulated tablets passed the uniformity of weight, friability, disintegration, and hardness tests. The tablets were found to contain the right amount of the extract and produced good in-vitro drug release throughout the duration of the study....
Read More
Posted by admin on Apr 30, 2021 in |
The present study aims to reveal the anti-inflammatory activity of the ethanolic plant extracts of Merremia tridentata against murine models. The Wistar Albino rats of mixed sex were induced inflammation via injecting histamine and formalin. The anti-inflammatory effect of Merremia tridetata was compared with the presence of positive control, Indomethacin. The Paw volume of the control group (group I and group II) have revealed the following mean and standard deviation values of 7.91±0.22 ml and 5.66±0.27 ml, respectively. Whereas the minimum and maximum dosages of plant extracts have shown the values 6.1±0.29 (200 mg/kg) and 5.49±0.18 ml. similarly, the histamine and Indomethacin control group I have revealed the following values 7.96±0.2 ml (group I) and 6.02±0.53 ml (group II). Likewise, the minimum and maximum dosage of plant extracts have revealed the maximum anti-inflammatory effect with the following values 6.30±0.60 ml (200 mg/kg) and 6.13±0.47 ml (400mg/kg). Hence, the present study has exerted the potential biological effect of M. tridetata might be useful for the development of alternative medicine for...
Read More
Posted by admin on Apr 30, 2021 in |
Prednisolone (10mg/day) plus low dose Aspirin (80mg/day) improve the implantation rate in women with autoimmune condition who are undergoing in-vitro fertilization. A new, simple, precise, accurate, and validated simultaneous equation method (Vierordt´s Method) has been developed for simultaneous determination of Prednisolone and Aspirin in the synthetic mixture. The method was based on the measurement of absorbance of both components at their ʎmax 243 nm and 226 nm of Prednisolone and Aspirin in methanol as solvent correspondingly. Linearity was obtained over a range of 2-6 µg/mL for Prednisone and 16-48 µg/mL for Aspirin. The percentage recovery obtained for Prednisolone and Aspirin was found to be in the range 98.85% to 99.95% and 99.41% to 99.74%, respectively. The results of the proposed method were validated for linearity, precision, accuracy, robustness, ruggedness according to ICH guideline Q2(R1). The developed method can be successfully be applied for simultaneous estimation of drugs in all commercial...
Read More
Posted by admin on Apr 30, 2021 in |
The Nilgiris District is one of the most botanized areas of Southern India. Asteraceae family is one of the largest families consisting of medicinal and aromatic plants in Nilgiris. The chemical compositions of Erigeron canadensis L. plant were investigated using Perkin-Elmer Gas Chromatography-Mass Spectrometry, while the mass spectra of the compounds found in the extract were matched by the National Institute of Standards and Technology (NIST) library. FT-IR and GC-MS analysis of ethanol extracts of Erigeron canadensis L. The shade-dried plant was powdered and subjected to selective sequential extraction using solvents of increasing polarity through percolation, for instance, using ethanol to obtain an ethanolic extract. Then, each of the extracts was further subjected to gas chromatography-mass spectrometry. GC-MS analysis of an ethanolic extract of Erigeron canadensis L. This revealed the existence of Methanethioamide, N,N-Dimethy (46.57%), N-Methylthio-acetamide (21.19%), Beta.-Sitosterol (7.80%), Disiloxane, Pentamethyl- (3.20%), Toluene P297 (3.18%), Benzene, 1,2-Dimethyl-(2.46%), Stigmasterol (2.40%), Acetic Acid, Diethoxy-, Ethyl Ester (2.39%), Benzene, 1, 2-Dimethyl- (2.15%), Phytol (1.41%), 1-Heptatriacotanol (1.09%) and Lupeol (0.90%). These results indicate...
Read More
Posted by admin on Apr 30, 2021 in |
Phoenix dactylifera is a medicinally important plant. Fruits are traditionally used for the nutritional purpose. Date seeds are the rich sources of phenolic acids which exhibits strong antioxidant property. HPTLC is a simple, versatile method and it provides visualization of separated constituents. The advantage of this method is this method requires a small amount of sample for analysis. The present work describes a simple, precise, and accurate HPTLC method for quantification of gallic acid, syringic acid, and vanillic acid present in seeds of date fruits. The analysis was done on CAMAG ATS4 automatic TLC sampler system. The chromatographic separation was carried out on precoated silica gel 60 F254 aluminum plates, using a mixture of toluene: ethyl acetate: formic acid (4:4:2 v/v) as mobile phase. The evaluation of spots was carried out at 254 nm using Camag TLC scanner 3. The aimed compounds were resolved satisfactorily with Rf 0.47, 0.53, and 0.60 for gallic acid, syringic acid, and vanillic acid, respectively. The developed method was validated by parameters linearity, accuracy,...
Read More
