Posted by admin on Apr 30, 2021 in |
Translabial drug delivery system is an attractive approach for drug delivery system possess advantages as a bypass of the first-pass metabolism, prevent from digestive enzymes and rapid action of suitable drugs. The purpose of the current research work is to isolate the biopolymer from Phoenix dactylifera (date palm) and prepare mucoadhesive bio-flexy films loaded with Phenytoin. The isolated biopolymer was subjected to various physicochemical characterization procedures for analyzing the mucoadhesive and mucoretentive properties. The mucoadhesive and mucoretentive properties of isolated biopolymer were analyzed using the shear stress method and the MS mucoretentibility method. The formulated Phenytoin loaded bio-flexy films were evaluated for weight, thickness, folding endurance, swelling index, surface pH, tensile strength, etc. The in-vitro drug release studies were analyzed using the static MS diffusion apparatus. Phenytoin loaded with HPMC and sodium CMC was used as standard film, and then results were compared. The optimized bio-flexy films shows order PD6 > PD5 > PD4 > PD3 > PD2 > PD1 on the basis of percentage release. The percent release...
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Posted by admin on Apr 30, 2021 in |
Objective: To evaluate the effect of some counterfeit anti-obesity drugs that are not licensed by the Ministry of Health. Materials and Methods: 100 male rats were divided into 10 groups. The first group received a normal diet for two months. The second group received a high-fat diet (HFD) for two months; the third group received HFD for one month then returned to a normal diet. The remaining seven groups received HFD for one month then treated with Orlistat, Turbo slim (dose 1), Turbo slim (dose 2), African mango (dose1), African mango (dose 2), Slim factor (dose 1), and Slim factor (dose 2) respectively for an additional one month. Bodyweight, glucose, insulin, leptin, adiponectin, MCP-1, reduced glutathione, MDA, lipid profile, kidney, and liver functions were measured. Adipose tissue index, atherosclerosis index, HOMA-IR, and QUICKI were calculated. Results: Feeding with HFD induced a significant increase in body weight as well as insulin resistance, serum lipids, serum leptin, plasma MCP-1, and tissue MDA and a significant decrease in serum adiponectin and tissue...
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Posted by admin on Apr 30, 2021 in |
The present study aimed to examine the anti-hypertensive constituents present in Nardostachys jatamansi. Crude solvent extracts (dichloromethane; ethyl acetate; methanol, and water) of this plant rhizomes based on the difference in polarity were prepared and tested for inhibition of angiotensin-converting enzyme (ACE). Preliminary phytochemical analysis showed bioactive compounds such as alkaloids, flavonoids, carbohydrates, triterpenoid, glycosides, saponin, and tannins in different extracts. Ethyl Acetate extract has shown better results with 93% inhibition at 100 µg concentration as compared to other solvent extracts. Fractionation of ethyl acetate extract over silica gel column chromatography with hexane and ethyl acetate under gradient elution resulted in six fractions. However, on purification of the ethyl acetate extract, ACE inhibition activity diminishes with only 19.03 to 47.35% inhibition for the purified fractions. Nardostachys jatamansi can be used to treat hypertension-related disorders, and ethyl acetate extract can be further investigated to identify potent molecules that work in a synergistic...
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Posted by admin on Apr 30, 2021 in |
The study evaluates the medicinal efficacy of Solanum capsicoides fruits as an antioxidant. Fruit extracts were prepared using acetone, ethanol, HCl, and water for the measurement of antioxidant potential by reducing power, DPPH radical scavenging activity, and CUPRAC assay and for the spectrophotometric determination of total phenol, flavonoid, anthocyanin, and carotenoid content. Chemical profiling of the fruit extract through GC-MS was also conducted. The total phenolic contents in extracts ranged between 1.2-4.25mg GAE g-1 FW and flavonoid contents in the range of 3.89-22.96mg QE g-1 FW. Among the various solvents used, acetone extract showed maximum antioxidant activity, and the least was observed in the water extract. Correlation coefficient analysis between bioactive compounds and antioxidant property revealed that TPC and TFC were positively and significantly correlated with antioxidant activity. A negative correlation was observed between the pigments, anthocyanins, and carotenoids, with DPPH and CUPRAC activity. The correlation between DPPH radical scavenging activity and carotenoids as well as TFC was not significant. In the case of RP, except carotenoids, all others...
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Posted by admin on Apr 30, 2021 in |
The prevalence of cancer is drastically increasing among cardamom farmers using chemical pesticides in Idukki district. The chemicals, mainly Organochlorine and organophosphates, result in various disease conditions. The main aim of the study was to explore the prevalence of cancer and other disease conditions among farmers and other people who were exposed to chemical pesticides. A community-based epidemiological study was conducted among cardamom farmers and people exposed to the chemical pesticides by using a pre-structured questionnaire containing socio-demographic details, information regarding chemicals, and their disease status. Descriptive and analytical statistics were applied for data analysis. A total of 237 members had interviewed. Among them, 47 were cancer patients, and 169 had comorbidities and other disease conditions. About 54 were suspected of cancer as per symptoms. Among cancers, breast cancer (36.17%) was detected as the major type, and the majority were females (23.3%). The majority of the patients 26 (28.3%) were worked for more than 20 years in the field. The majority of patients with cancer (22.3%) were not taken...
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