Posted by admin on May 31, 2021 in |
The aim of the present study was to formulate and evaluate Budesonide proniosomes for enhancement of solubility and bioavailability. To develop and evaluate budesonide proniosomes was the main objective of this research work. For the preparation of proniosomes slurry, a method was used using different ratios of (cholesterol: surfactant) (1:1.5) with the help of carriers. For optimization of formulation Box-Behnken Design was used in that concentration of span 60, cholesterol, and maltodextrin. The prepared proniosomes were evaluated for particle size, entrapment efficiency, and in-vitro drug release (up to 6 h). Particle size, entrapment efficiency, and drug release of optimized batch (F14) were found to be 220.3 nm, 81.42%, and 30.71%, respectively. The data were fitted into a zero order model, and the correlation value found to be 0.952, indicating controlled release. Transformation of niosomes from proniosomes and morphology study of the optimized batch was studied by Inverted Microscopy and Transmission Electron Microscopy, etc. Statistical analysis of ex-vivo permeation enhancement assessed from the flux, permeability coefficient, and enhancement ratio was...
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Posted by admin on May 31, 2021 in |
Herbs are the main source of Ayurvedic formulations. Polyherbalism concept of Ayurveda enables fortified therapeutic effect when compared to single herb. The potency of polyherbal formulations depends on their ingredients. Plants tend to vary in their efficacy due to the influence of environmental factors, such as temperature, humidity, light, oxygen, moisture content. The quality of polyherbal formulations depends on factors like selecting the raw material, habitat, season, harvesting conditions, method of storage, and pharmaceutical processing. Hence the evaluation parameters for polyherbal formulations should be based on chemical, physical, microbiological, therapeutic and toxicological assessment. Standardization for each formulation is unique. The monograph thus prepared will be useful to ensure the quality of the pharmaceutical product. Palasha beejadi Choorna (PBC) is a formulation indicated and frequently prescribed as the best choice for krimiroga. It is mentioned in Rasoddaratantra and in the Ayurvedic Formulary of India (AFI). Aims and objective: The objective of the study is to standardize Palasha beejadi choorna of Rasoddaratantra, mentioned in the Ayurvedic Formulary of India. Methodology PBC...
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Posted by admin on May 31, 2021 in |
Worldwide, Tuberculosis (TB) remains the most frequent and important infectious disease caused by Mycobacterium tuberculosis (Mtb). TB Structural Genomics Consortium (TBSGC) reported 79,144 deaths and 26.9 lakh cases in 2019 (WHO). Although tuberculosis is a curable disease, the chances of a cure become slim as the disease becomes multidrug-resistant, and the situation gets even worse as the disease becomes extensively drug-resistant. The emergence of multidrug-resistant varieties of Mycobacterium tuberculosis has led to a search for novel drug targets. The objective of this paper is based on the drug designing for the potential drug target Murd Ligase protein from M. Tuberculosis. This drug target is involved in vital aspects of the pathogen’s metabolism, persistence, virulence, and cell wall biosynthesis. In this study, we have built a homology model of the protein Murd Ligase based on homology technique using SPDBV and further, the model is analyzed with various existing drugs and docking enzyme inhibitors that reveal the structural information for the development of effective anti-tuberculosis drugs using...
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Posted by admin on May 31, 2021 in |
A new, simple, rapid, accurate, and economical method has been developed for the simultaneous estimation of Lamivudine and Tenofovir Disoproxil Fumarate in formulation by using a quality by design approach. Design expert software was used for QbD analysis. 03 level factorial quadratic design models were used to analyze the response. The model generated was found to be significant. The optimized conditions of factors were concentration 10ug/ml and wavelength (λmax) 272 nm for LAM and 259 nm for TDF. The distilled water was used as a solvent for analysis. The linearity was observed in the concentration range of 02-100 µg/ml for Lamivudine and Tenofovir Disoproxil Fumarate, both drugs. The simultaneous equation method was used for estimation, and the method was validated as per ICH guidelines. The recovery of Lamivudine and Tenofovir Disoproxil Fumarate was found in the range of 98.90-100.77% and 101.63-102.43%. The stability testing was done as per ICH guidelines. The developed method may be used by industries for analyzing their products....
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Posted by admin on May 31, 2021 in |
Cathepsin S enzyme has been considered as an evolving target for the development of novel therapeutic agents for the treatment of numerous autoimmune disorders and other inflammatory diseases. Using TSAR 3.3 2D QSAR has been performed on a series of dipeptide nitrile nucleus. Attempts have been made to derive and comprehend a correlation between biological activity and the generated descriptors. The study was carried out using 37 compounds by division into training and test set by a random selection method. A final QSAR model was generated from a set of 28 compounds with the Leave-out one row (LOO) method of cross-validation to estimate the model’s predictive ability. The most significant model with n = 28, r = 0.969, r2 = 0.939, r2cv = 0.801, s value = 0.35, f value = 89.07 was developed using MLR analysis. For PLS, the fraction of variance explained = 0.928 was observed. A comparable PLS model with r2 = 0.928 and Neural model with r2 = 0.962 indicated good internal predictability of the...
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