Posted by admin on Feb 28, 2021 in |
Diabetes mellitus caused by inherited and/or acquired deficiency in insulin production or by the development of insulin resistance. This is chronic as well as moderately increasing day by day in developing countries as well as globally and has reached about to the epidemic ratio, and now it is a matter of worry for the populations. This deficiency results in increased blood glucose concentrations, which damages many of the body’s systems, in particular the blood vessels and nerves. There are several medications available for the disease. Worldwide, different drugs are prescribed in different manners as well as amount, which may cause severe side effects known as adverse drug reactions (ADRs). So, ADR monitoring is being an important task to reduce the damage by the drugs taken for the disease treatment. This study was performed for the ADRs monitoring of anti-diabetic medication in OPD of tertiary care hospital of northern...
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Posted by admin on Feb 28, 2021 in |
Ethnomedicinal plant-like Gymnosporia montana belonging to the family Celastraceae is commonly known as Vikalo in Gujarat. Ethanomedicinally, fresh leaves of Vikalo are chewed in trible regions of Gujarat to cure jaundice. Phytochemical screening of the plant showed the presence of phytoconstituents like phenol, flavonoids, alkaloids, triterpenoids, and saponin. The present study was undertaken for Phytochemical Investigation, Isolation and Characterization of Betulin from the leaf of Gymnosporia montana. On the basis of characterization studies, the novel compound betulin was isolated by column chromatography; the isolated compound has been evaluated for its physical properties (colour, state, solubility, melting range, and Rf value), which identically resembles the standard...
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Posted by admin on Feb 28, 2021 in |
This study reports the isolation and antioxidant activity of non-polar terpenes extracted from the leaves of Bougainvillea glabra choicy. To characterize the phytochemical constituents of Bougainvillea glabra leaves using the GC-MS method. The 95% ethanol extract was filtered, distilled, and concentrated to obtain the solid greenish residue. The residue was further fractioned by n-hexane, chloroform, ethyl acetate, acetone, ethanol, and methanol. The GC-MS analysis of Chloroform extract of Bougainvillea glabra leaves revealed the presence of thirteen compounds that could contribute to the medicinal quality of the plant. The first compound identified with less retention time (9.50 min) was 1-(1-methyl-decyl)-decahydro-napthalene. The isolation of organic compounds was done using column and thin layer chromatographic techniques. Compound characterization using various spectroscopic techniques identified the final isolated compound as 1-(1-methyl-decyl)-decahydronapthalene. Antioxidant activity was evaluated by the DPPH method. The method of isolation is simple, cost-effective, and...
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Posted by admin on Feb 28, 2021 in |
The aim of the present work is to formulate and characterize Econazole nitrate (EN) loaded transfersomal gel for antifungal activity. EN is a broad-spectrum imidazole antifungal agent that belongs to BCS Class II. Due to poor solubility, EN is incompletely absorbed after oral administration and bioavailability vary among individuals. Topical treatment of fungal infections is usually preferred, but the barrier is to cross stratum corneum, so formulating the drug in Transfersomes (TFs) solved this problem. TFs are a highly adaptable, stress-responsive, complex aggregate, and self-regulating membrane. EN loaded transfersomes were prepared by a thin-film hydration method. The EN-loaded transfersomes were optimized by the three factors and two levels Box-Behnken design using Design-Expert software (version 12). Independent formulation variables such as concentrations of phospholipid and two edge activators were evaluated. The prepared TFs were evaluated with respect to particle size, % entrapment efficiency, and % drug release. The prepared EN loaded TFs particle size ranging from 0.28 to 0.71 µm, entrapment efficiency in between 31.5 to 75%, and drug release...
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Posted by admin on Feb 28, 2021 in |
RP-HPLC method has been developed for separation and quantification of Metoprolol succinate, Telmisartan, and Clinidipine using Phenomenex Luna C18 column (150 mm × 4.6 mm, 5 µm) as a stationary phase with security guard cartridge C18 (4 × 3 mm) and acetonitrile: methanol: phosphate buffer pH 7.5 (45:30:25) as a mobile phase by isocratic elution at the flow rate of 1.0 ml/min. The detection was carried out at 229 nm. The drugs are eluted at retention times 2.0, 2.8, and 6.8min for telmisartan, metoprolol succinate, and clinidipine, respectively. The method is linear in the range of 10-80 μg / ml, 6.25-50 μg / ml, and 2.5-20 μg / ml with regression coefficients 0.997, 0.995, and 0.999 respectively for telmisartan, metoprolol succinate, and clinidipine. The method is precise within the acceptable limits (% RSD- 1.22). The proposed method showed linearity, accuracy, precision, specificity, robustness, LOD, LOQ, and system suitability results within the acceptance criteria of ICH. The method can be applied for the routine analysis of pharmaceutical...
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