Posted by admin on Jan 31, 2021 in |
Natural resources potentials, such as animals or plants, have been utilized as a traditional herb and can be benefitted for human health and to support the government program in medication to be back to nature. The body parts often used for the traditional drug are meat, horn, tail, feather, nail, fat, bile, and shell. The animal’s potential to develop as medicine meets the following criteria: easily found, available in high numbers, and able to cure severe disease, and has economic value. In Central Kalimantan, one of the allergy treatment hereditarily practiced is the utilization of charcoal of inedible body parts of ocellated snakehead Channa pleurophthalmus Blkr, such as head skin, scale, and fins. This study was carried out to know the charcoal characteristics of ocellated snakehead (Channa pleurophthalmus Blkr) body parts in relation to its potential as an anti-allergic drug. The examination covered chemical composition, water content, rendement, charchoal absorbability, in-vivo test on a male rat, and pyrolysis-GC/MS (Py-GC/MS)-based active compound identification. Results showed that the charcoal was dominated...
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Posted by admin on Jan 31, 2021 in |
Pyrimidine derivative had a wide range of biological activities, including antiTB activity. In this view, pyrimidine moiety containing N N5-(3-substituted benzylidene)-N4-phenyl and N5-(2-substituted benzylidene)-N2,N2-dimethyl-N4-phenyl compounds was designed, and a novel series of N5-(3-substituted benzylidene)-N4-phenyl pyrimidine-4,5-diamine [5A-5F]/N5-(2-substituted benzylidene)-N2,N2-dimethyl-N4-phenyl pyrimidine-2,4,5-triamine [5a-5f], were synthesized, evaluated for their antiTB activity against MTB H37Ra strain by MABA screening. Among the all 12 derivatives tested, N5-(4-methoxybenzylidene)-N4-phenylpyrimidine-4,5-diamine[5A], N5-(4-chloro benzylidene)-N4-phenylpyrimidine-4,5-diamine [5C], N5-(4-chloro benzylidene)-N2, N2-dimethyl-N4-phenyl pyrimidine-2,4,5-triamine [5c], and N5-(4-amino benzylidene)-N4-phenyl pyrimidine-4,5-diamine [5E] was found to have potent activity against MTB H37Ra strain. The compounds bearing electron-withdrawing, donating group’s substitution, and its positioning function was important to produce significant activity proved. The obtained results showed that the most active compounds could be useful as a template for future design, structural modification, and investigation to produce more active...
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Posted by admin on Jan 31, 2021 in |
Since ancient times, herbal knowledge has been used in the field of health care by different cultures. Ginger and garlic are important herbs that have covered a wide role in various health ailments like kidney and heart diseases. Also, they are considered to be potential against suppressing toxicity. The present study was conducted to evaluate the toxicity suppressing capability of these two herbs against residual pesticides. Residual pesticides were extracted from apples by solvent extraction procedure. Onion tips were allowed to grow in water containing residual pesticides. Aqueous extracts of ginger and garlic were prepared for the study. The study was classified into groups: group1: control/normal (root tips grown in distilled water); group 2: root tips treated with residual pesticide; group 3: root tips treated with a combination of residual pesticide and garlic extract and group 4: root tips treated with a combination of residual pesticide and ginger extract. Mitotic index was documented using a paper microscope (Foldscope). The result was recorded for 24 h and 72 h. In...
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Posted by admin on Jan 31, 2021 in |
In the present investigation, a series of some novel 4-[substituted-2-hydroxy-phenyl]-2-(4′-dimethylamino-phenyl)-2, 3-dihydro-1, 5-benzothizepines (2a-l) have been synthesized by the treatment of 1-(substituted-2-hydroxy-phenyl)-3-(4′-dimethylamino-phenyl)-prop-2-en-1-ones (chalcones) (1a-l) with 2-aminothiophenol using ethanol as a solvent in the presence of catalytic amount of Lanthanum Nitrate in short reaction time with excellent yield (70-80%) by a conventional method. The products were tested for purity by TLC, and structures of newly synthesized compounds were confirmed by IR, 1H NMR, and Mass spectral analysis. All these newly synthesized compounds were evaluated for their antibacterial activity against Escherichia coli, Salmonella typhi, Staphylococcus aureus, and Bacillus subtilis and antifungal activity against Aspergillus niger, Penicillium chrysogenum, Fusarium moneliforme, and Aspergillus flavus, using Penicillin and Greseofulvin as standard drugs. Most of the compounds showed significant...
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Posted by admin on Jan 31, 2021 in |
Kanuga (Pongamia pinnata), a plant belonging to Leguminosae described in Vedas has ethnobotanical importance and a variety of medicinal properties. Pongamia pinnata, commonly grown on the roads of India is used to heal wounds, treat many fungal infections, skin diseases and to clean teeth. The objective of the current study is to perform phytochemical analysis and appraise the antimicrobial activity of hydro-alcoholic bark extract of Pongamia pinnata. Dried, powdered bark was extracted with water and ethanol (1:1) mixture by soxhlation for 72 h. Following the standard tests of phytochemical investigation, the hydro-alcoholic bark extract subsumes constituents like flavonoids, phenolic compounds, carbohydrates, saponins, glycosides, and alkaloids. Minimum Inhibitory Concentration (MIC) of the hydro-alcoholic bark extract was evaluated by serial tube dilution method, and MIC for Bacillus subtilis, Escherichia coli, and Aspergillus niger was 100 µg/ml, 100 µg/ml, and 100 µg/ml, respectively. The antimicrobial activity of hydro-alcoholic bark extract of Pongamia was assessed by agar well diffusion method. Organisms used for antimicrobial assessment include Bacillus subtilis, Escherichia coli, and Aspergillus niger....
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