Posted by admin on Jan 31, 2021 in |
The current communication deals with the development of Al3+ -ion induced ionotropically gelled microbeads made of deacetylated gellan gum (GG) and Dillenia indica L. fruit gum (DG) blends for sustained release of drugs. Aceclofenac (ACE) was utilized as a model drug candidate in the current study. These GG-DG microbeads of ACE were formulated by ionotropic gelation using AlCl3 as ionotropic cross-linker. In this microbead formulation, various formulation parameters like amount of GG, amount of DG and concentration of AlCl3 were varied and analyzed. These various GG-DG microbeads of ACE demonstrated ACE entrapment efficiency of 24.94 ± 0.32 to 72.76 ± 2.83% and an average micro-bead size of 698.56 ± 19.76 to 955.08 ± 40.62 µm. ACE releasing from various GG-DG microbeads in the in-vitro study was found to be sustained over 8 h. Optimized GG-DG microbeads of ACE followed the Korsmeyer-Peppas model (R2 = 0.9918 to 0.9982) with super case-II transport mechanism of a drug (ACE) releasing. The optimized GG-DG microbeads of ACE (F-O) were also characterized by various...
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Posted by admin on Jan 31, 2021 in |
The purpose of the current study was to investigate the diuretic and renal effect of the aqueous extracts of Laurus nobilis leaves and dried flower buds of Syzygium aromaticum. Four groups of rats were used. Group 1 received distilled water (10 ml/kg BW), group 2 received the aqueous extract of Laurus nobilis (300 mg/kg BW), group 3 received the aqueous extract of Syzygium aromaticum (300 mg/kg BW) and group 4 received furosemide (15 mg/kg BW). The interventions were administered daily for nine days. The urinary volume was measured every day. On day nine, the kidneys were removed for histological analysis, the urine and blood samples were obtained from each rat to analyze urine and plasma potassium, sodium, chloride and creatinine, serum urea, and serum albumin. Renal clearance, saluretic activity, estimation of the carbonic anhydrase inhibition activity, osmolar clearance, plasma osmolarity, free water clearance, free water reabsorption were calculated. The results showed that furosemide and both plants extract produced a significant increase in diuresis, creatinine clearance, and saluretic index, furosemide...
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Posted by admin on Jan 31, 2021 in |
Oregano oil is an essential oil possessing anti-inflammatory, antioxidant, antimicrobial, and immune-boosting properties that can be used in the treatment of various skin disorders. However, its practical applications are limited due to its handling issues and poor stability in the presence of air, light, and high temperature. To overcome these problems, this study aims to entrap oregano essential oil (OEO) in ethyl cellulose (EC) microsponges to get decreased dermal toxicity and enhanced stability. The quasi emulsion solvent diffusion method was utilized for fabrication of the OEO microsponges using EC as polymer, dichloromethane (DCM) as a solvent and polyvinyl alcohol (PVA) as stabilizer. The effect of formulation variables like stirring rate, stirring time and quantity of polymer were also examined. The prepared microsponges were evaluated for particle size and production yield. Results revealed that all microformulations were in the micro size range (19.87 mm to 248.13 mm), with a good production yield (72.85%) of M6. Spherical uniform shape with a spongy structure of microsponges was confirmed by Scanning Electron Microscopy...
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Posted by admin on Jan 31, 2021 in |
The study was performed with Methanolic Periwinkle leaf extract and aqueous Amla fruit extract. The activity was tested on Staphylococcus aureus and Escherichia coli by Agar Well Diffusion Method. Further, Silver Nanoparticles were synthesized from these Plant extract by Biological Method. Periwinkle leaf and Amla fruit extract showed antimicrobial activity against E. coli and S. aureus and also showed the synthesis of Silver Nanoparticles. The Biosynthesized SNPs were measured on a colorimeter. The λmax for Periwinkle leaf was found to be 0.32 nm and that 0.65 nm for Amla fruit. This Biosynthesized SNPs of plant extracts was again tested for Antimicrobial Activity using Agar Well Diffusion Method and showed significant inhibition of S. for S. aureus and 24 mm for E. coli. The results of antimicrobial activity for plant extract of Periwinkle leaf and Amla fruit indicates that they inhibit the growth of S. aureus and E. coli. Antimicrobial activity of biosynthesized silver nanoparticles was tested against E. coli and S. aureus; the zone of inhibition obtained by biosynthesized...
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Posted by admin on Jan 31, 2021 in |
Growth and development events in plants are controlled by growth regulators and Phytohormones. These are found naturally in plants. Environmental Pollution is one of the major problems and reactions caused by artificial growth regulators and their low biodegradability has urged us to search for new biofertilizers with growth-regulating activity. Vermiwash is a liquid fertilizer that has been shown to mimic phytohormones in bringing about growth-promoting effects. In the present study vermiwash at 100% and 50% concentration and Gibberellic acid treatment along with a control treatment with distilled water were given to Hibiscus cannabinus L.,a conventional fiber crop in order to determine the growth-promoting effect of vermiwash in comparison to Gibberellic acid. The results showed that vermiwash at lower concentration was able to bring about enhanced growth which has been observed as an increase in the height of the plant, length and width of internode and has been substantiated by an increase in the bast fiber zone as seen from the histological studies. It is thus revealed that vermiwash could...
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