Posted by admin on Mar 31, 2021 in |
We presented an eco-friendly procedure for effective and fast preparation of biologically active substituted pyrimidine ligand through a condensation reaction of 1,8-diaminonaphthalene and 2-methoxy-benzaldehyde with Fe3O4@SiO2@L-valine magnetic nanoparticles (MNPs) as a new recyclable catalyst. In this experiment, we aim to increase reaction efficiency for the synthesis of 2-(2-methoxyphenyl)-2,3-dihydro-1H-perimidine ligand. Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), Energy dispersive X-ray spectrometer (EDXA), scanning electron microscopy (SEM), and vibrating sample magnetometry (VSM) were employed to characterize the catalyst. Findings demonstrated that synthesized nanocatalyst is superparamagnetic with a dimension range of 15-30 nm. The catalyst was readily recycled using an external magnet and could be recovered several times without considerable reduction in its catalytic performance. Furthermore, the metal complexes were produced from 2-(2-methoxyphenyl)-2,3-dihydro-1H-perimidine ligand. Antibacterial activities of ligand and its metal complexes were studied against G(+) and G(-) bacteria strains by disc diffusion technique. Results showed that metal complexes had better biological activities compared to parent ligands. Among the synthesized compounds, the best antibacterial activity was observed by Cu...
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Posted by admin on Mar 31, 2021 in |
Enalapril maleate competitively inhibits the ACE to hinder the production of angiotensin II, a key component of the rennin angiotensin aldosterone system that promotes vasoconstriction and reabsorption of sodium ion in the kidney, overall decrease in blood pressure. The study’s main objective was to formulate and evaluate bioadhesive buccal tablets to avoid the first-pass metabolism in the liver and patient acceptance. Bioadhesive buccal tablets were prepared by direct compression method using bioadhesive polymers like Chitosan, Carbopol 934, and HPMC K100M in different ratios to a drug. The physicochemical compatibility of drugs and polymers was studied by FT-IR spectroscopy. Prepared tablets were evaluated for permeation study through the porcine buccal mucosa, in-vitro drug release, swelling index, moisture absorbance, surface pH; among the prepared formulation containing F6 Shows maximum drug release 88.5 % in 8 h the optimized formulation F6 showed surface pH 6.9 and swelling index 82.2%. The formulation followed Peppas order release kinetic non Fickian...
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Posted by admin on Mar 31, 2021 in |
Rosuvastatin and Telmisartan are used together as a fixed dosage combination to treat hypertension associated with dyslipidemia. Objective: To develop and validate a simple, sensitive, precise, ecofriendly and cost-effective method for the determination of Rosu-vastatin and Telmisartan in bulk and pharmaceutical formulation as per ICH Guidelines. Methods: an effort has been made to develop a simple double beam UV Spectrophotometric method and validate the same with different parameters such as Linearity, Precision, Repeat-ability, Limit of Detection (LOD), Limit of Quantification (LOQ), Accuracy, Robustness, and Ruggedness. Results: Rosuvastatin and Telmisartanin Ethanol: Water 60: 40% v/v shows maximum absor-bance at 244 nm and 296 nm, respectively. Beer’s law was obeyed in the concentration range of 2-10µg/mL and 3-15µg/mL; The LOD and LOQ were found to 0.35µg/mL and 1.06 µg/ Rosuvastatin mL for Rosuvastatin and 0.54 µg/mL and 1.64 µg/mL for Telmisartan respectively. Recovery of Rosuvastatin and Telmisartan in tablet formulation was observed in the range of 80.00-120.00%. Conclusion: The proposed method is precise, accurate, eco-friendly and reproducible and can be used...
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Posted by admin on Mar 31, 2021 in |
Ipomoea pes-tigridis (IP) is a twinning hairy herb grown in India. Based on the ethnopharmacological information of the plant, the ethanolic extract of the whole plant of Ipomoea pes-tigridis was evaluated for its anticonvulsant, antianxiety activity in mice. The Antiepileptic activity was assessed by using MES (maximal electroshock) model (200 and 400 mg/kg), and antianxiety activity was assessed by using the hole board and open field test. Bodyweight doses were used for the present study. In MES model, the ethanolic extracts showed a dose-dependent reduction in duration of the hind limb extensor phase when compared with the control group. It is evident that the mice which were treated with 400 mg/kg of EEIP (Ethanolic extract of Ipomoea pes-tigridis) showed a significant (P˂0.0001) effect in all the phases on MES induced convulsion. In HBT (hole board test), It was noted that the mice which were treated with 400 mg/kg of EEIP showed a high significance (P˂0.0001) effect on the number of head dipping due to the anxiolytic activity. In OFT...
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Posted by admin on Mar 31, 2021 in |
Diabetes mellitus is a metabolic disorder of the endocrine system and becoming a serious threat to mankind’s health in all parts of the world. Herbal remedies are considered convenient for management of diabetes due to their traditional acceptability, availability, and less side effects than oral hypoglycaemic agents. Thus, the present study aims to test the toxic and antidiabetic effect of a traditionally used herbal mixture of C. nilgiriensis and P. marsupium in STZ induced diabetic rats. No mortality, abnormal behaviour, and physiological changes were noted in all doses of herbal mixture treated rats and did not cause any toxic oriented effects even in the high dose during toxicity studies. Thus 200 mg/kg bwt dose of the herbal mixture was selected to evaluate their antidiabetic activity. Herbal mixture treated rats exhibited a significant reduction in blood glucose level (One way ANOVA, f3,12 =525.78; p<0.005), HbA1c level (One way ANOVA, f3,12= 87.35; p<0.005), and a significant increase in serum insulin level (One way ANOVA, f3,12=418.0; p<0.005). The herbal mixture also proved...
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