Posted by admin on Apr 30, 2021 in |
Malnutrition is a condition in which there is an imbalance in the proportion of essential nutrients that the body requires to stay healthy. The most prevalent form of malnutrition is micronutrient deficiency and of this iron deficiency anaemia is the most common type, affecting over 2 billion people worldwide. Micronutrients are a special class of vital ingredients that are required in minuscule quantities to perform a wide range of physiological functions. The current therapy for the treatment of Iron deficiency anaemia has many drawbacks like gastrointestinal side effects, erratic absorption of iron, etc. To overcome the above side effects, we tried to develop and evaluate a site-specific sustained-release combined drug delivery system of Iron and Folic acid. Iron as Ferrous ions is preferentially absorbed in the jejunum. To facilitate the absorption of iron, the gastro retentive multiunit particulate system (GRMUPs) was developed comprising Ferrous Ascorbate is a source of iron. Colon targeted tablet was developed for Folic acid to localize and maximize the absorption of Folic acid in the...
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Posted by admin on Apr 30, 2021 in |
Preliminary screening study had employed to extract inhibitors of calcium oxalate (CaOx) crystallization in-vitro from four plant species, namely Saraca asoca, Berginia ciliata, Boerhavia diffusa, and Crateva nurvala These plants were selected based on their frequent medicinal usage by folks. Plant material (150 g) used for this study was successively extracted with Soxhlet apparatus using the solvents in order of increasing polarity (ethyl acetate, acetone, ethanol and water). Each time the marc was dried and later extracted with other solvents. All the extracts were concentrated by distilling the solvent in a rotary vacuum evaporator. An extracts were prepared at different concentration (1 mg-10 mg/ml). Nucleation assay and aggregation assay of calcium oxalate crystals were measured using spectrophotometric methods. The plant extracts promoted the precipitation of calcium oxalate particles in buffer and inhibited calcium oxalate crystal aggregation which clearly indicates the antilithiatic activity of these plants. Phytocompounds present in this plant may be responsible for the anticrystallization activity. Statistical difference and percentage inhibitions were calculated and assessed. The results were...
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Posted by admin on Apr 30, 2021 in |
Ibuprofen is a widely used non-selective non-steroidal anti-inflammatory drug. Ibuprofen oral use is restricted by its potential gastric toxicity, which can be overcome utilizing alternative drug delivery routes. A novel micellar transdermal delivery of Ibuprofen was readily prepared herein using the solubility enhancing co-polymeric excipient polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (Soluplus®). Ibuprofen polymeric micelle systems were prepared at a wide range of concentrations and characterized by particle size analysis, rheology measurement, infrared spectroscopy, and differential scanning calorimetry. Nanosize micelles were obtained (< 100 nm), with a small polydispersity index, at 0.5 – 2% concentration range of Soluplus®. The aqueous solubility of Ibuprofen was significantly enhanced in Soluplus®micelle system. The highest solubility was achieved at a concentration of 2% of Soluplus® with an approximate ten-fold increase in solubility. Moreover, statistical analysis of Ibuprofen’s permeation from Ibuprofen polymeric micelle systems against a control sample revealed an increase in the cumulative drug permeation with increasing polymer...
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Posted by admin on Apr 30, 2021 in |
The aim of the present study was to enhance the solubility of the poorly soluble drug Ranolazine. Solid dispersions were prepared using PVP K-30 and PEG 4000 & 6000 by melting, solvent evaporation using varying polymer ratios (1:1, 1:2, 1:3, 1:4). The prepared formulations were characterized for saturation solubility, IR, PXRD, SEM. The aqueous solubility of Ranolazine was favored by the presence of polymers. In contrast to the very slow dissolution rate of pure Ranolazine, amorphous solid dispersions considerably improved the dissolution rate. PXRD, DSC, SEM studies confirmed the amorpicity of Ranolazine. The saturation solubility of pure drug RN was found to be 0.142mg/ml, whereas that of SD4 was found to be 0.77mg/ml. The drug release of the pure drug was 28.70% at the end of 3 hours and the drug release was found to be enhanced in SD4 that is 96.44% and SD8 is 84.85%. The formulations SD4 and SD8 showed the highest solubility and dissolution rate. This can be attributed to the increased wettability and dispersibility of...
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Posted by admin on Apr 30, 2021 in |
A simple stability-indicating high-performance thin-layer chromatographic method which is economic, selective, and precise for analysis of Sofosbuvir (SFB), both as a bulk drug and in formulations, was developed and validated according to ICH guidelines. The method employed HPTLC precoated Merck TLC plates RP-18 F254 as the stationary phase while the solvent system prepared by mixing n-Hexane: Ethyl Acetate: Methanol in proportion 5:3:2 v/v. The system was found to give a compact spot for the drug (Rf value of 0.452 ± 0.004). Densitometric analysis of SFB was carried out in the absorbance mode at 261 nm. The linear regression analysis data for the calibration plots showed a good linear relationship, R2 = 0.9994, with respect to peak area in the concentration range 100-600 ng/band. The LOD and LOQ were 8.009 ng/band and 24.270 ng/band, respectively. SFB was subjected to hydrolysis, oxidation, and thermal degradation, which indicates the drug is susceptible to hydrolysis, oxidation, and heat. The method was validated for precision, recovery, and robustness. Statistical analysis proves that the method...
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