Posted by admin on Oct 31, 2024 in |
Recently, there has been increasing interest in donkey’s milk. Donkeys’ milk is a good alternative source for infant nutrition in the case of cow milk protein allergy and substitute to human milk. The main aim of this study was to evaluate and compare the proximate composition and physico-chemical properties of Andalusian breed donkey milk with different species mainly buffalo, cow and goat milk obtained from Kamareddy district of Telangana state. The milk samples were analyzed for proximate composition like fat, protein, carbohydrate, ash and total solids, physico-chemical properties such as pH, specific gravity, titratable acidity and viscosity. It was observed from the results that among all the species buffalo and goat milk showed higher levels of all the constituents than that of cow and donkey milk. The specific gravity, titratable acidity, ash, and protein content of buffalo milk showed higher than donkey milk, but had a lower lactose level than donkey, goat and cow milk. All the tested parameters were similar in buffalo and goat milk except lactose which...
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Posted by admin on Oct 31, 2024 in |
Purpose: The main purpose was to develop Oro-dispersible tablet to overcome the problem of dysphagia which is common in pediatric, geriatric and unconscious patients. Method: The Oro-dispersible tablets were prepared by direct compression method by using two different individual superdisintegrant like Sodium Starch Glycolate and Crospovidone as well as combination of superdisintegrant with newly marketed filler-binder Isomalt were used. Friability, disintegration time and percent drug release were taken as dependent variable. The excipients were used like Avicel as directly compressible excipient, Talc and Magnesium Stearate as lubricant, Sodium Saccharine and Mannitol as sweetening agent. The tablets were evaluated for hardness, friability, thickness, weight variation, wetting time, water absorption ratio, disintegration time and in-vitro drug release study. Venlafaxine hydrochloride, commonly used as anti-hypertensive and has anxiolytic property, poor bioavailability due to extensive first pass metabolism. Results: It was observed that hardness of all tablets was 3.13-4.11 Kg/cm2, friability of all formulation was found to be less than 1%, Weight variation was as per the USP specification and maximum % drug...
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Posted by admin on Sep 30, 2024 in |
Background: Peptic ulcer disease (PUD) is an injury of the duodenal mucous membrane that normally occurs due to an imbalance between the aggressive and the defensive factors. It accounts for an estimated lifetime prevalence of 5-10% globally. Aim: To evaluate the anti-ulcer effect and phytochemical constituents of extract and fractions of the leaves of D. guineense using an indomethacin-induced ulcer model. Methods: The powdered leaves were cold macerated in 95% v/v of methanol for 48 h. The extract was partitioned successively using ethyl acetate (EtOAc), and n-butanol to obtain their respective fractions. Phytochemical screening was conducted using validated methods. An acute toxicity study was carried out by modified Lorke’s method. The anti-ulcer study was conducted using an indomethacin-induced rat model. Results: The yield of the extract was 4.1% w/w while EtOAc and n-butanolfractions yielded 0.36 and 0.93% w/w respectively. There was presence of tannin, flavonoids, saponins and terpenoids in the methanol extract. Acute toxicity study indicated no mortality or any behavioural changes even at an oral dose of 5000...
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Posted by admin on Sep 30, 2024 in |
Pharmaceutical corporations have been heavily involved in the development of natural plant-based goods to create the most economical and cost-effective medicines for the underprivileged in recent years. Plants are abundant natural product suppliers. One of such natural sources having great medicinal value is Croton bonplandianum, commonly known as ‘bantulasi’; Family: Euphorbiaceae. Because Croton bonplandianum is an alien plant species, the presence of alkaloids, flavonoids, saponins, steroids, resins, phenols, and rutin gives rise to its very useful medicinal value. It is used to treat skin problems, wounds, and high blood pressure. Three distinct guinea pig and frog experimental models were used in this investigation to screen the Croton bonplandianum extracts. The extract at dilutions 1:10, 1:50 and 1:100 showed the anesthetic activity in a dose-dependent manner in contrast to the typical medication xylocaine (0.2%). The techniques include lumbar plexus anesthesia, nerve block anesthesia, frog muscle twitch, guinea pig infiltration anesthesia, and surface anesthesia in rabbits. It was concluded that extracts of Croton bonplandianum possess local anesthetic...
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Posted by admin on Sep 30, 2024 in |
Background: Epilepsy, characterized by repetitive seizures, is studied using pentylenetetrazole (PTZ) in animals. PTZ, a GABA-A inhibitor, is used in various doses in mice to evaluate drug efficacy against seizures. Method: In a PTZ-induced mouse model, different PTZ doses were evaluated: 80 mg/kg i.p., 75 mg/kg i.p., and 80 mg/kg s.c. Seizure behaviors were analyzed, including mortality rates, GTCS frequency and latency, myoclonic jerks, GTCS duration, and post-injection interictal phase duration. Results: Frequency of GTCS was found to be highest, latency to GTCS and myoclonic jerks was least and duration of GTCS was more in PTZ 80 mg/kg, i.p., group, while the PTZ 80 mg/kg; s.c. was found to have longest inter-ictal phase. These are important criterion for the evaluation of any investigational drug for antiepileptic effect. The mortality rate was found to be the same in PTZ 75 mg/kg; i.p. and 80 mg/kg; s.c. (12.5%) groups, while in PTZ 80 mg/kg; i.p. it was found to be highest (25%). The PTZ 80 mg/kg, i.p., for comparison of seizure...
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