Posted by admin on Mar 31, 2021 in |
Tuberculosis is one of the major contagious diseases and a leading cause of death in humans. Current treatment methods suffer from a multitude of problems like long duration of treatment, lack of patient compliance, presence of drug-resistant bacteria, etc. To combat the disease effectively, there is an urgent need for the development of new drugs effective against both drug-sensitive and drug-resistant bacteria. Cynodon dactylon is known to be effective against cough and other lung diseases. The objective of the present study is to identify the component in Cynodon dactylon, which is therapeutically effective against Mycobacterium tuberculosis by in-silico docking analysis using Autodock. Here InhA, the enoyl acyl carrier protein reductase from Mycobacterium tuberculosis was taken as the target protein for docking analysis. Phytochemicals from Cynodon dactylon were selected based on molecular and ADME properties. Among the phytochemicals investigated, luteolin showed a good docking score and better interaction with the target protein and is comparable to the commercially available first-line antitubercular drug, isoniazid. Based on our preliminary analysis of molecular...
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Posted by admin on Mar 31, 2021 in |
Milk is a complex system where analysis of metal ions is a difficult task due to the presence of interfering materials. The formation of a coloured complex between the metal and a coloured or colourless ligand is the basis for the development of spectro-photometric methods. The aim of this study is to analyze and estimate copper present in various samples of milk (i.e., cow, buffalo, goat, camel, soya, and powdered milk) by micellar spectrophotometry method. For this purpose, the ligand N-(2’-Pyridyl)-2-hydroxy-benzamide (NPHB-2) was synthesized by the reaction of 2-aminopyridine with salicylic acid, which is a weak acid and is found to be soluble in alcohol, acetone, and chloroform. It is insoluble in water at a pH less than 7. In addition to the solution of this ligands to copper (II) solution in the presence of micellar medium, a yellowish-green or light green coloured complex is formed immediately. It has been observed that in the presence of a micellar medium, solubility, as well as absorption intensity, has been found to...
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Posted by admin on Mar 31, 2021 in |
As the incidences of Coronavirus (SARS CoV-2) infections have been increasing at a rapid pace, the need for its containment and treatment has taken center stage for numerous research institutions. The similarity of SARS CoV-2 with that of SARS CoV has led to a jumpstart in the research activities on corona-virus on the same. The number of research articles appearing since the time SARS CoV-2 was discovered has skyrocketed. While every research group has been busy in pushing the research information to the next level, hardly any convincing research has come up the effective treatments or therapeutics against the disease. In this study we conduct a bibliographic analysis for SARS CoV, MERS CoV and SARS CoV-2, and statistically compare the incidence of research articles combining along the “treatment” and ‘therapies” as keywords. We attempt to draw trends and conclusions based on the data available on the databases...
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Posted by admin on Mar 31, 2021 in |
Marine bacteria have the potentiality to produce diverse bioactive molecules such as pigment. Therefore, it needs to exploit and identifying a novel type of pigment from marine bacteria for Industrial applications. This study aimed to investigate the marine bacterial pigment against antioxidant and anti-cancer properties; the marine bacteria producing pigment were isolated from water samples collected at the coastal of Marakkanam (TN), India. The isolates were screened out based on the growth characteristics and performance of different media and the strain designated as MB4, which was taken as further studies. The strain MB4 characterized by SEM analysis showed that coccoid cell morphology, nonsporulating, Gram-positive with yellow pigmentation and positive for MR-VP, catalase, lipase, acetoin production, and hemolysis. The cells were able to tolerate 10 percent NaCl concentration and ability to grown pH 9. The MB4 strain was shown a higher wave-number (1395.77) cm-1 against Raman Intensity to identify pigment production. The methanolic extracted pigment was produced at a maximum peak at 260 nm. The yellow-pigmented crude extract checked for...
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Posted by admin on Mar 31, 2021 in |
Medicinal plants are becoming globally recognized because of their acclaimed therapeutic potentials. This study evaluated the plasma glucose and serum lipid profile levels among university students consuming Glycine max (Soya bean) in Nnewi, Nigeria. A total of thirty (30) apparently healthy male subjects aged between 18 and 30 years were randomly recruited from medical students to serve as both test and control groups. Each subject was advised to abstain from soya bean and similar food consumption for a period of three weeks prior to the commencement of the study. Subsequently, in addition to their normal diet, each of the subjects was given 25 g of soya bean powder before breakfast daily for 30 consecutive days. 6 mls each of baseline and test samples (after an overnight fast) were collected at day 0 and 31 respectively from each subject for the determination of plasma glucose and lipid profile parameters (TC, TG, LDL-C, HDL-C, and VLDL-C) using standard laboratory methods. Results showed no significant alterations in the mean body mass index...
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