Posted by admin on Jan 31, 2021 in |
Introduction: In India, lung carcinoma is the 5th most common tumor and 2nd most common tumor in males as per the ICMR [Indian Council of Medical Research] registry of 2002. In our Indian set up, smoking is still a leading cause of lung cancer and related morbidity and mortality. The role of many cancer stem cell markers like CD133, ALDH1, etc., is being investigated in the origin and prognosis of lung cancer. Cancer stem cells (CSCs) have gained increasing attention recently in cancer research. CSCs have the ability to generate new tumors through their stem cell properties, essentially self-renewal potential and differentiation into multiple cell lineages. Aim: we planned a study correlating Cancer stem cell marker CD133 with smoking in newly diagnosed lung cancer patients. Material and Methods: Lung biopsies of a total of 55 patients visiting Era’s Lucknow Medical College and hospital and King George Medical University, suspected to be suffering from lung cancer, were taken in this pilot study for a period of 18 months. Lung tissue...
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Posted by admin on Jan 31, 2021 in |
Acne vulgaris is a skin condition in which people lose their self-esteem and ultimately lead to depression. It is more common among the adolescent age groups. According to GBD (Global burden of disease) study, about 85% of the populations are being affected. Various medications are available for the treatment, but, its uses are limited due to side effects like skin irritation. In our study, we have formulated a novel combination nanoemulsion gel containing adapalene and resveratrol for the treatment of pustules, assuming that it won’t produce much skin irritation and also expecting a synergistic activity. The spontaneous emulsification method was employed for the preparation of nanoemulsion, and it was incorporated into carbopol 934 gel. Further, various evaluation tests, including in-vitro and in-vivo studies, were performed. Cumulative percentage drug release was more for marketed formulation as compared to prepared formulation, whereas, the prepared formulation had a better efficacy as compared to marketed formulation. Thus, we can say that the formulation has exhibited its synergistic activity on combining with a polyphenol....
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Posted by admin on Jan 31, 2021 in |
Plant Euphorbia hirta L. is a common weed plant that belongs to the family Euphorbiaceae characterized by the presence of milky latex in leaves and stems. Phytochemical screening of leaves of Euphorbia hirta L. confirmed the presence of alkaloids, cardiac glycosides, flavonoids, phenolic compounds, tannin and terpenoids. FT-IR confirms the formation of calcium oxalate crystals with major peaks at 3331.07, 1608.63, 1317.38, and 775.38, which corresponds to asymmetric O-H bending, C=O stretching, C-O stretching and C-H bending. Nucleation and aggregation assay has been done to investigate the in-vitro antiurolithiatic potential of leaves of Euphorbia hirta L., and significant % inhibition has been observed for nucleation and aggregation of calcium oxalate kidney stones. Maximum % inhibition has been observed at 1000 µg/ml concentration with 55.81% and 73.17% inhibition, respectively. % inhibition of nucleation and aggregation increases with the increasing concentration of plant E. hirta. GC- MS confirmed the presence of different active...
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Posted by admin on Jan 31, 2021 in |
Studies of natural products emerge as an important medicinal resource. An example is the use of Zanthoxylum chiloperone (Rutaceae) for medicinal purposes against neglected diseases, as for example, Chagas disease and leishmaniasis. The analysis of the chemical composition of this medicinal plant was carried out by chromatrographic techniques to evaluate its pharmacological applications. The use of factorial design is currently the most common optimization technique used in the design of chromatographic experiments. We proposed the optimization and validation of the analytical methods, working with high-performance liquid chromatographic coupled with array diode array detection (HPLC-DAD), and finally, we developed the first stability test of natural 5-methoxycanthin-6-one (5-MCT). The establishment of the analytical methodology was performed using a full factorial design. The quantitative determination of 5-MCT was validated with the parameters of the factorial design: temperature of 25 ºC, methanol concentration of 70%, and flow of 0,8 mL/min. Preliminary stability tests showed that some conditions presented significant reductions of 5-MCT, and the respective equations were formulated. Ten related degradation products were...
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Posted by admin on Jan 31, 2021 in |
Evaluation of nootropic activity of Semecarpus anacardium leaves ethyl alcohol extract on exteroceptive behavior and interoceptive behavior was investigated by use of Shuttle box, Continuous Avoidance Response Apparatus and Elevated plus-maze test, Scopolamine-induced amnesia, Diazepam-induced amnesia, and Sodium nitrite-induced amnesia. The beha-vioral study was done using Lithium- induced head twitches (5-HT mediated behavior) test. The ethyl alcohol leaves extract was administered orally in two different dosages to male albino rats (100 and 200 mg/kg daily, p.o. & isolated flavonoid 40 mg/kg daily p.o) and Swiss albino mice (100 and 200 mg/kg Daily p.o. & isolated flavonoid 40mg/kg daily p.o). The result was compared to piracetam (100 mg/kg, p.o) used as a standard drug. The buzzer (conditioned stimulus) and an electric shock (unconditioned stimulus, 30 v and 0.5 sec) were used in the Shuttle box. The ethyl alcohol extract of Semecarpus anacardium leaves showed statically significant improvement in memory retention and learning when compared to control. The study shows that the ethyl alcohol extract of Semecarpus anacardium leaves has the...
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