Posted by admin on Mar 31, 2021 in |
Enalapril maleate competitively inhibits the ACE to hinder the production of angiotensin II, a key component of the rennin angiotensin aldosterone system that promotes vasoconstriction and reabsorption of sodium ion in the kidney, overall decrease in blood pressure. The study’s main objective was to formulate and evaluate bioadhesive buccal tablets to avoid the first-pass metabolism in the liver and patient acceptance. Bioadhesive buccal tablets were prepared by direct compression method using bioadhesive polymers like Chitosan, Carbopol 934, and HPMC K100M in different ratios to a drug. The physicochemical compatibility of drugs and polymers was studied by FT-IR spectroscopy. Prepared tablets were evaluated for permeation study through the porcine buccal mucosa, in-vitro drug release, swelling index, moisture absorbance, surface pH; among the prepared formulation containing F6 Shows maximum drug release 88.5 % in 8 h the optimized formulation F6 showed surface pH 6.9 and swelling index 82.2%. The formulation followed Peppas order release kinetic non Fickian...
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Posted by admin on Mar 31, 2021 in |
Rosuvastatin and Telmisartan are used together as a fixed dosage combination to treat hypertension associated with dyslipidemia. Objective: To develop and validate a simple, sensitive, precise, ecofriendly and cost-effective method for the determination of Rosu-vastatin and Telmisartan in bulk and pharmaceutical formulation as per ICH Guidelines. Methods: an effort has been made to develop a simple double beam UV Spectrophotometric method and validate the same with different parameters such as Linearity, Precision, Repeat-ability, Limit of Detection (LOD), Limit of Quantification (LOQ), Accuracy, Robustness, and Ruggedness. Results: Rosuvastatin and Telmisartanin Ethanol: Water 60: 40% v/v shows maximum absor-bance at 244 nm and 296 nm, respectively. Beer’s law was obeyed in the concentration range of 2-10µg/mL and 3-15µg/mL; The LOD and LOQ were found to 0.35µg/mL and 1.06 µg/ Rosuvastatin mL for Rosuvastatin and 0.54 µg/mL and 1.64 µg/mL for Telmisartan respectively. Recovery of Rosuvastatin and Telmisartan in tablet formulation was observed in the range of 80.00-120.00%. Conclusion: The proposed method is precise, accurate, eco-friendly and reproducible and can be used...
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Posted by admin on Mar 31, 2021 in |
Ipomoea pes-tigridis (IP) is a twinning hairy herb grown in India. Based on the ethnopharmacological information of the plant, the ethanolic extract of the whole plant of Ipomoea pes-tigridis was evaluated for its anticonvulsant, antianxiety activity in mice. The Antiepileptic activity was assessed by using MES (maximal electroshock) model (200 and 400 mg/kg), and antianxiety activity was assessed by using the hole board and open field test. Bodyweight doses were used for the present study. In MES model, the ethanolic extracts showed a dose-dependent reduction in duration of the hind limb extensor phase when compared with the control group. It is evident that the mice which were treated with 400 mg/kg of EEIP (Ethanolic extract of Ipomoea pes-tigridis) showed a significant (P˂0.0001) effect in all the phases on MES induced convulsion. In HBT (hole board test), It was noted that the mice which were treated with 400 mg/kg of EEIP showed a high significance (P˂0.0001) effect on the number of head dipping due to the anxiolytic activity. In OFT...
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Posted by admin on Mar 31, 2021 in |
Diabetes mellitus is a metabolic disorder of the endocrine system and becoming a serious threat to mankind’s health in all parts of the world. Herbal remedies are considered convenient for management of diabetes due to their traditional acceptability, availability, and less side effects than oral hypoglycaemic agents. Thus, the present study aims to test the toxic and antidiabetic effect of a traditionally used herbal mixture of C. nilgiriensis and P. marsupium in STZ induced diabetic rats. No mortality, abnormal behaviour, and physiological changes were noted in all doses of herbal mixture treated rats and did not cause any toxic oriented effects even in the high dose during toxicity studies. Thus 200 mg/kg bwt dose of the herbal mixture was selected to evaluate their antidiabetic activity. Herbal mixture treated rats exhibited a significant reduction in blood glucose level (One way ANOVA, f3,12 =525.78; p<0.005), HbA1c level (One way ANOVA, f3,12= 87.35; p<0.005), and a significant increase in serum insulin level (One way ANOVA, f3,12=418.0; p<0.005). The herbal mixture also proved...
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Posted by admin on Mar 31, 2021 in |
Malaria is a parasitic infectious disease transmitted through the bite of female Anopheles mosquitos. Every year, approximately 210 million Peoples are suffering from this dangerous disease, and around 440,000 individuals pass from this infectious disease. Recently, the Indonesia Ministry of Health declared that the malaria pre-elimination stage should be reached by 2020 and be free of malaria transmission by 2030 to achieve the goal of an Asia-Pacific free of malaria by 2030. So, this study focused on the discovery of novel anti-malarial and medication targets against malaria. The three-dimensional (3D) structures of PFHGPRT, HSHGPRT, and TCHGPRT were used for comparative docking study, while two inhibitors 6-(2, 2-Dichloro-acetamido) chrysene and GMP-2′, 3′-dialdehyde were used as a lead for designing and discovery of potential inhibitor of PFHGPRT with the help of various software. The three-dimensional structure (3D) of pfHGPRT (3OZF) and (4RAO) PfHGPRT was isolated from its intricate structure and was utilized for docking study, and comparably, HsHGPRT was isolated from its perplexing structure, and it also utilized for docking study....
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