Posted by admin on Nov 30, 2020 in |
Lansoprazole and Domperidone, used as Proton pump inhibitor and antiemetic agents, especially for disease related to gastric ulcer. The purpose of the research was to improve aqueous solubility of drugs by β-CD using a different method, and perform phase solubility study of both drugs using β-CD and calculate Ks, and ∆Gt. Prepare Complex of LAN and DOM with β-CD using different methods like physical mixture, kneading and co evaporation. Complexes were evaluated for drug content. Based on characterization and dissolution study, kneading method based complex was optimized and tablet prepared using different superdisintegrants like Sodium Starch Glycolate, Cross Povidone, Cross Carmellose Sodium as a synthetic super disintegrating agent and Isphagula, Banana powder and Mango powder as a natural super disintegrating agent. Prepared tablets were evaluated for pre-compression and post-compression parameters such as hardness, friability, disintegration time, wetting time, dissolution study and accelerated stability study. Prepared tablets loaded with complex were compared with a marketed tablet for dissolution study. Optimized complex molar ratios for both drugs were 3:1 and have...
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Posted by admin on Nov 30, 2020 in |
The present study describes the anti-implantation activity of Thespesia populnea bark extracts (ethanol, ethyl acetate, and aqueous)on female albino rats. Extracts were tested for possible anti-implantation activity in albino female rats of the proestrus cycle after overnight cohabitation with males of proven fertility. The drugs were administered to pregnant female rats from day 1 to 7th day of pregnancy. On the 8th day, the rats were laparotomies under light anesthesia, and the numbers of implantation sites were counted, and the reproductive hormonal levels were assessed. The present results revealed that the short term treatment of T. populnea bark extracts reduced the number of implantation sites in the uterus. It also significantly altered the reproductive hormonal level by increasing FSH and LH level and decreasing progesterone, prolactin, and estradiol level. Thus, it is concluded that T. populnea extracts possess significant anti-implantation...
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Posted by admin on Nov 30, 2020 in |
The present investigation was carried out to isolate, characterize, and to study the antagonistic properties of the endophytic microbes from leaves, bark, flower, and fruits of Myristica malabarica. Standard protocols were followed for the isolation and characterization of bacterial and fungal endophytes. Altogether 16 endophytic fungal isolates and three bacterial isolates were isolated from 51 different plant segments of M. malabarica. Three fungi were identified as Aspergillus sp., Penicillium oxalicum, and white sterile mycelium. Bacterial isolates were Gram-positive and Gram-negative cocci and Gram-positive cocco-bacilli. Antagonistic activities of these organisms were tested against Sclerotium rolfsii. Compare to bacterial isolates, fungal endophytes showed good activity. The isolated endophytes were subjected to an abiotic stress tolerance study against a different range of salt and temperature in which all the three endophytic fungi showed very high growth activity only at 25 °C and 37 °C and failed to grow in other temperatures. Fungal isolates showed good amylase, cellulase, and pectinase activity, whereas bacterial isolates exhibited varied activity with respect to...
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Posted by admin on Nov 30, 2020 in |
The objective of the present study was to develop Empagliflozin and Metformin hydrochloride extended release tablets, comprising immediate release empagliflozin and extended release metformin hydrochloride in a single tablet. Wet granulation process was employed to develop extended release part metformin hydrochloride. Impact of various formulation variables in extended release part was assessed using statistical interpretation such as analysis of variance. A 32 (two factor, three level) factorial design was employed to study the effect of independent variables (binder concentration [sodium CMC] and ER polymer [HPMC K100M CR/polyethylene oxide/carbopol] concentration)on dependent variables (drug release at 1, 4 and 10h). Optimization was done by fitting experimental data to the software program (design expert). The design space for formulation variables and its influence on drug release was developed. In-vitro release data observed from the optimized formulation was fitted into various kinetic equations. Extended release part drug release was extended for 12 h following zero order kinetics and non-fickian diffusion process. Extended drug delivery system of empagliflozin and metformin hydrochloride extended release tablets...
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Posted by admin on Nov 30, 2020 in |
In today’s modern lifestyle, there is an increase in the development of various instant food products. To meet consumer requirements, the food choice will depend on several factors. The present study was aimed with the objective to formulate a value-added instant soup mix with nutritional and sensory charac-teristics. Further, the prepared instant soup mix was subjected to antioxidant and shelf life studies. Three different combinations (A-I, P-I and N-I) were prepared. The coefficient of friction (COF) was minimum for glass surface and maximum for plywood surface for all three products. The results of the moisture ranged from (6.82-7.99%), had different levels of ash content ranged from (7.40-12.49). The concentration of protein of sample NI (28.62%) was having the highest compared to PI (21%) and AI (19.36%). The carbohydrate content was found to be high in A1 (55.06%) compared to NI (46.55) and PI (44.98). The crude fiber, fat and saturated fat, and mineral contents are comparable with the three combinations. High mineral content was observed in NI sample compared...
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