Posted by admin on Nov 30, 2020 in |
Background: Early childhood caries is a rapidly progressing type of dental caries in children. It can lead to partial or complete loss of crown structure. Grossly decayed anterior teeth often lead to discomfort, and the child may face psychological, aesthetic, functional, and phonetic problems that affect the quality of life of the child, and it poses a challenge for the dentist to preserve the teeth until the eruption of succedaneous teeth. Case Description: This case report discusses the aesthetic reconstruction of grossly decayed primary maxillary incisors using Glass Fiber- Reinforced Composite Post and Core in a 5-year-old female patient. Placement of intracanal posts in pulpectomy treated teeth improves the retention of a coronal restoration. This technique of Glass Fiber- Reinforced Composite Post and Core restoration has shown promising results in the literature and has presented children’s dentist with an alternative treatment option for preserving the grossly decayed primary anterior...
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Posted by admin on Nov 30, 2020 in |
In nature, lectins or glycoproteins are ubiquitous, abundantly distributed. Lectinsplayan an important role in plant defense mechanism against microorganisms. This fact has greatly attracted many research groups working in the field of biotechnology, agriculture, and medicine. Jamun or black plum is a fruit with many health benefits. This paper focuses on the phytochemical investigation of trichloroacetic acid precipitated proteins from leaves, pulp, and seeds. The glycoproteins were characterized by hemagglutination, hemagglutination inhibition, and tested the stability at different temperatures and pH on blood groups by and tested their efficacy on human Peripheral Blood Mononuclear Cells. Phytochemical investigations of trichloroacetic acid precipitated test sample defined the occurrence of protein and absence of other phytochemicals. Blood group O+ showed a quick response of agglutination. Both pulp and leaf extracts showed cytotoxicity and genotoxicity on human Peripheral Blood Mononuclear Cells in a dose-dependent manner. Glycoproteins were stable at varying temperatures and pH. The current study results indicated that the jamun fruit extract is also a potent anti-proliferative agent against lymphocytes. However, further...
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Posted by admin on Nov 30, 2020 in |
Objective: To study the in-vitro antioxidant as well as nephroprotective potentials of Crinum asiaticum bulbs’ethanolic extract in contrast to gentamicin-induced nephrotoxicity in albino rats. Materials and Methods: The ethanolic extract of Crinum asiaticum bulbs subjected to preliminary phytochemical analysis to determine the phytoconstituents and evaluation of antioxidant activity was done using in-vitro methods like DPPH as well as lipid peroxidation assays using ascorbic acid as standard. In-vivo nephroprotective activity was estimated by utilising gentamicin induced nephrotoxicity in albino rats. Results: It was revealed by the preliminary phytochemical analysis that phenolics, tannins, steroids, terpenoids, and flavonoids components are presented. The promising results obtained by in-vitro antioxidant activity promoted us to evaluate gentamicin induced nephrotoxicity in rats. Gentamicin impeded nephrotoxicity in rats as proved by extremely substantial (p<0.001) rise of blood urea, serum creatinine and uricacid in Group II in comparison to Group I. Also, administration of Gentamicin in group II caused oxidative stress in rats proposed by considerable increase in LPO level as well as considerable decrease in GSH level....
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Posted by admin on Nov 30, 2020 in |
Eclipta alba (Family-Asteraceae) is a herb commonly used in traditional Ayurvedic medicine for the treatment of inflammation, pain, and wounds. The present study is aimed to validate the ethnobotanical use of Eclipta alba in an animal model. The animals were induced with arthritis by injection of FCA on day 0 and treated with wedelolactone rich fractions of Eclipta alba (100, 200 and 400 mg/kg) from day 12 to day 28. WEA caused a significant effect in arthritis by inhibiting the joint inflammation and decreasing hyperalgesia and allodynia. WEA significantly decreased the biochemical markers and serum Tumor Necrosis factor-α, Interleukin 1β and Interleukin-6 levels and significantly increased the antioxidant profile. WEA (400 mg/kg) exhibited anti-rheumatic activity as evidenced by altered hematological milieu (ESR, CRP, WBC, RBC and Hb), histopathology of ankle joints, reduced cytokine levels, paw volume and related parameters associated with arthritis. Taken together, these results demonstrated the antiarthritic activity of WEA against experimental arthritis, and the underlying mechanism behind this efficacy might be mediated by inhibition of proinflammatory...
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Posted by admin on Nov 30, 2020 in |
The objectives of the present investigation were to formulate and evaluate of Medicated oral jelly containing Trazadone HCl for the treatment of depression. Many psychotic patients are medicinal phobic who are afraid of taking medicine, so this preparation is most beneficial over that type of fear. Trazadone HCl antidepressant drugs incorporate in jelly and give to those patients; in this way, we could administer medicine to them without bringing this to their attention. Jellies are prepared by heating and congealing methods by dispersing gelling agents in water and evaluated for their physicochemical parameters like appearance, stickiness, pH, viscosity, Spreadability, stability studies, drug release, and content uniformity. All batches (F1-F8) of medicated jelly showed acceptable and comparable appearance, pH, viscosity, Spreadability, stability studies, drug release, and content uniformity. The viscosity range was found to be 53305 to 61731cps. The drug content of F1 to F8 formulations was found to be in the range of 88.42 to 98.95%. F7 batch prepared with gelatin + xanthan gum combination shows 98.95%. drug...
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