Posted by admin on Nov 30, 2020 in |
The aim of the present study was to investigate the effect of Curcumin on blood glucose levels, body weight changes, and oxidative stress markers in the diabetic rat liver. Diabetes exacerbates hepatic injury induced by hyperglycemia mediated oxidative stress. A marked decrease in the blood glucose levels, body weight changes and anti-oxidant marker enzymes, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and increase in malondialdehyde (MDA) was observed in the diabetic rats. Decreased activities of antioxidant enzymes and body weights in diabetic rats were augmented on the oral administration of Curcumin. Moreover, Curcumin administration depleted the MDA level, which was earlier increased in the diabetic rats. These results suggest that Curcumin exhibits a hepatoprotective effect by accelerating hepatic anti-oxidant defense mechanisms and downregulating the MDA levels to the normal levels in the diabetic rats. Thus, Curcumin may be used as a therapeutic agent in preventing complications in diabetic...
Read More
Posted by admin on Nov 30, 2020 in |
During the present investigations attempt was made to the green synthesis of silver nanoparticles using root extract of Aerva tomentosa Forsk. and to analyze its antibacterial and antioxidant activities. Exposure of the root extract of Aerva tomentosa to aqueous AgNO3 resulted in the formation of silver nanoparticles. The synthesis of silver nanoparticles was confirmed by UV-Vis spectrophotometer and was characterized by X-ray diffractometer. The bactericidal activity of silver nanoparticles against Escherichia coli, Bacillus thuringiensis, Bacillus subtilis and Pseudomonas putida was determined using bacterial growth inhibition method. The antioxidant study of silver nanopartcles was analyzed by the 2, 2-diphenyl-1-picrylhydrazil (DPPH) radical scavenging method. The synthesis of AgNPs via this green approach by Aerva tomentosa root extract were average size particles and crystalline in nature. The synthesized silver nanoparticles with two concentrations (0.01g/100µl) and (0.005g/100µl) exhibited high antibacterial activity in terms of maximum zone of inhibition against Escherichia coli, Bacillus thuringiensis, Bacillus subtilis, and Pseudomonas putida. Silver nanoparticles also showed significant antioxidant activity. There was a dose-dependent increase in the percent antioxidant activity...
Read More
Posted by admin on Nov 30, 2020 in |
Syzygium aqueum is a well-known edible fruit-bearing plant species. The tribal people in Malaysia used different parts of the plant to cure various ailments. The previous studies on phytochemical evaluation of S. aqueum are very limited. The present study aims to conduct a detailed investigation of phytochemicals present in the leaves of S. aqueum and also its potential use as an effective antioxidant agent. In this study, the methanolic leaf extract of S. aqueum was tested to determine its chemical composition and its antioxidant activity. The result of the preliminary phytochemical investigation in leaf extract of S. aqueum revealed the presence of several bioactive secondary metabolites such as phenolic compounds, flavonoids, tannins, steroids, and terpenoids. Quantification results showed that the total phenol was found to be 62.89±1.48% GAE and the flavonoid content was 15.05±0.36% QE. Further analysis of the antioxidant activity in leaf extract of S. aqueum using different antioxidant assays proved that the extract effectively scavenging diverse types of free radicals. In different antioxidant assays, the leaf extract...
Read More
Posted by admin on Nov 30, 2020 in |
The medicinal herbs used by native people of Mexico since ancient times for numerous therapeutic purposes. The plant is inborn to Mexico but is now well familiarized throughout India on wastelands. In India Martynia annua L. is a well recognized small herbaceous annual plant. The present study was carried out with HPTLC, and the results showed that there were many photochemical in Martynia annua L. Pre-coated HPTLC graded plates and autosampler was used to achieve precision, sensitive, significant separation both qualitatively and quantitatively. From HPTLC studies, it has been found that Petroleum-ether, acetone, and methanol extracts contain a mixture of compounds. Therefore, it is established that the pharmacological activity shown by them was due to the cumulative effect of all the compounds in a composite. Total eleven compounds identified; the most prevailing compounds were, Oleic acid (30.61%), 2, 5-dihydroxybenzoic acid (36.3%), 1-Hexyl-2-nitrocyclohexane (31.01%), and Cynidin-3-galactoside (34.14%). Other components were Apigenin-7-A-D, glucoside (4.4%), Pelargonidin-3, 5-diglucoside (12.9%), Ethanol, 2-(2-aminoethoxy) – (16.78%), n-Hexadecanoic acid (17.13%), Eicosanoic acid (18.55%), Chlorogrnic acid (25.07%) and...
Read More
Posted by admin on Nov 30, 2020 in |
The aim of the present work was to characterize the starchy components of Amorphophallus paeoniifolius tuber and evaluate its potential as a binder. The tuber starch was extracted and characterized in terms of Phyto-chemical and physicochemical properties. Cyproheptadine was selected as model drug, and drug excipient compatibility studies were carried. Granules containing 5%, 7.5%, 10%, and 12.5% of isolated starch were prepared by wet granulation and evaluated for pre and post-compression parameters. The isolated sample was white in color and free from contaminant with moderate flow properties. The drug was found to be compatible with excipients, as revealed in the FTIR study. Prepared granules were found to have good flow property and compressibility as evident from the angle of repose and Carr’s compressibility index. The tablets were also evaluated for hardness, friability, disintegration time and in-vitro dissolution and all the result were found to be in the standard limit as per I.P. Results shows that Amorphophallus paeoniifolius starch can be used as a tablet binder and could be effectively...
Read More
