Posted by admin on Nov 30, 2020 in |
The main objective of the study was to develop an RP-UPLC method for the simultaneous determination and validation of the Daunorubicin and Cytarabine in the pharmaceutical dosage form. The technique was developed by using the Mobile phase containing Buffer 0.01N KH2PO4: Acetonitrile used in the ratio 50:50 v/v and X-Bridge C18 (2.1 × 100 mm, 1.6 µm) as a stationary phase at a flow rate of 0.3 ml/min. The buffer used in this method was 0.01N KH2PO4 (3.5 pH) buffer pH was accustomed by means of the solution of 0.1% OPA. The temperature was maintained throughout the method at 30°C, and the optimized wavelength chosen was 240.0 nm. The technique was developed and thoroughly validated based on the ICH (International Conference on Harmonization) guidelines. The validation process was done by precision, linearity, robustness studies, accuracy, Limit of Detection, Limit of quantification, and degradation studies. The robustness studies were observed by making variations in the mobile phase, temperature, and flow rate. The accuracy was observed at more than 96% recovery....
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Posted by admin on Nov 30, 2020 in |
The present developed method was designed to fabricate an innovative, simple, cost-effective, and compatible method for controlled delivery of Metformin hydrochloride (MF) by the use of natural and synthetic polymers for comparative analysis. For the most commonly used anti-diabetic drug Metformin hydrochloride, we have tried to formulate microspheres by incorporating natural and synthetic polymers separately in order to identify the most appropriate and safe type of controlled drug delivery system. All the fabricated microspheres formulations were characterized for various evaluating parameters like percentage yield, particle size analysis, micromeretic study, entrapment efficiency of drug, in-vitro drug release, FTIR study, XRD analysis, and quantitative analysis of most optimized formulation by using high-performance liquid chromatography (HPLC) method. The formulations from F1to F5 were prepared by using natural polymer sodium alginate, by ion- gelation technique, and the formulation code from F6 to F10 represents microspheres formulated by using synthetic polymer by emulsion-solvent evaporation technique. It was observed that all prepared formulations showed improved flow behavior than a pure drug; on increasing the polymer...
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Posted by admin on Nov 30, 2020 in |
Background: Diabetic postmenopausal women and osteoporosis are both chronic conditions and the relationship between them are complex. Objective: The aims of this study were to assess the socio-demographic factors inflicted in Diabetic postmenopausal women with Osteoporosis condition. Method: A Prospective, comparative and interventional study with a convenient sample of 520 Diabetic postmenopausal subjects were recruited from both inpatient and outpatient: Orthopedic, General Medicine and Obstetrics and Gynecology departments in Malla Reddy Hospital, measuring Bone Mineral Density (BMD) at the heel bone using QUS. In addition, tabulated self – reported data forms, about the socio-demographic details of subjects were collected. Results: The QUS measurements at the culmination of the study deduced that 520 Diabetic postmenopausal women posed a high risk of anomalous BMD were 17% (n=89), whereas Low risk of anomalous BMD accounted for 61% (n=317) and No risk accounted for 22% (n=114), out of validated subjects. The socio-demographic and osteoporotic conditions were illustrated. There were significant differences in QUS-score (normal BMD, Osteopenia and osteoporosis) patient demographic details like current...
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Posted by admin on Nov 30, 2020 in |
Zinc Ferrite nanoparticles were prepared by chemical co-precipitation method, using PEG as the capping agent. The synthesized materials were annealed at different temperatures such as 400, 500, 600, 700 and 800 °C and the structural characterization studies were conducted by X-Ray Diffraction (XRD), Fourier Transform Infrared Spectrometer (FTIR), UV-Visible Spectro-scopy and Field Emission Scanning Electron Microscopy (FESEM). On heat treatment of the as prepared samples, crystallite size was observed to increase from 5 nm-22 nm. XRD pattern confirmed the single crystalline phase of developed particles. It was observed that the particle size and X-ray density of the annealed ZnFe2O4 nanoparticles linearly increased with increase in annealing temperature and decrease in lattice parameters. The calculated micro strain values were found to be decreasing with increasing annealing temperatures. The nanoparticle size was confirmed using SEM measurements. Furthermore FTIR mapping confirmed the presence of ZnFe2O4 nanoparticles. The calculated band gap (Eg) of zinc ferrite nanoparticles decreases with increase in temperature. The antibacterial activity of ZnFe2O4 nanoparticles was studied against gram negative E-coli...
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Posted by admin on Nov 30, 2020 in |
Lansoprazole and Domperidone, used as Proton pump inhibitor and antiemetic agents, especially for disease related to gastric ulcer. The purpose of the research was to improve aqueous solubility of drugs by β-CD using a different method, and perform phase solubility study of both drugs using β-CD and calculate Ks, and ∆Gt. Prepare Complex of LAN and DOM with β-CD using different methods like physical mixture, kneading and co evaporation. Complexes were evaluated for drug content. Based on characterization and dissolution study, kneading method based complex was optimized and tablet prepared using different superdisintegrants like Sodium Starch Glycolate, Cross Povidone, Cross Carmellose Sodium as a synthetic super disintegrating agent and Isphagula, Banana powder and Mango powder as a natural super disintegrating agent. Prepared tablets were evaluated for pre-compression and post-compression parameters such as hardness, friability, disintegration time, wetting time, dissolution study and accelerated stability study. Prepared tablets loaded with complex were compared with a marketed tablet for dissolution study. Optimized complex molar ratios for both drugs were 3:1 and have...
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